Dong Xie
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View article: Machine learning-based differentiation of benign and malignant adrenal lesions using 18F-FDG PET/CT: a two-stage classification and SHAP interpretation study
Machine learning-based differentiation of benign and malignant adrenal lesions using 18F-FDG PET/CT: a two-stage classification and SHAP interpretation study Open
Machine learning models based on PET/CT-derived features enable highly accurate and interpretable classification of adrenal lesions. Integrating metabolic and anatomical parameters improves diagnostic precision, while SHAP analysis offers …
View article: Epigenetic profiling reveals key super-enhancer networks driving oncogenesis in HPV-positive HNSCC
Epigenetic profiling reveals key super-enhancer networks driving oncogenesis in HPV-positive HNSCC Open
Human papillomavirus-positive (HPV+) head and neck squamous cell carcinoma (HNSCC) is a growing subset of cancer cases distinct from HPV-negative by fewer genetic mutations and prevalent epigenetic dysregulation. We mapped H3K27ac-marked s…
View article: Super-resolution reconstruction of thermal property distributions in transient thermoreflectance
Super-resolution reconstruction of thermal property distributions in transient thermoreflectance Open
Pump–probe thermoreflectance technique encounters challenges in balancing high spatial resolution and high-throughput testing during wafer-level scanning. To address this, we introduce super-resolution reconstruction (SR), an emerging comp…
View article: The Effect of Electroacupuncture on Microcirculation in Patients With Hypertension and Cognitive Impairment: Protocol for a Multicenter Randomized Controlled Trial
The Effect of Electroacupuncture on Microcirculation in Patients With Hypertension and Cognitive Impairment: Protocol for a Multicenter Randomized Controlled Trial Open
Background Hypertension is a significant risk factor for cardiovascular diseases and is associated with an increased risk of mild cognitive impairment (MCI). The lack of effective treatment for these conditions underscores the urgent need …
View article: Efficacy of acupuncture therapy plus related rehabilitation therapy for post-stroke urinary incontinence: a systematic review and meta-analysis
Efficacy of acupuncture therapy plus related rehabilitation therapy for post-stroke urinary incontinence: a systematic review and meta-analysis Open
Introduction Researchers have increasingly focused on the efficacy of acupuncture therapy (AT) combine with rehabilitation therapy (RT) for post-stroke urinary incontinence (PSUI). This study aims to fully assess the efficacy of AT plus re…
View article: Translation and cultural adaptation of the Chinese version of the International ‘Care Of the Dying Evaluation’ (CODE™) tool for assessing the quality of care for dying patients from the perspective of bereaved family members
Translation and cultural adaptation of the Chinese version of the International ‘Care Of the Dying Evaluation’ (CODE™) tool for assessing the quality of care for dying patients from the perspective of bereaved family members Open
A questionnaire allowing for international comparisons related to quality of care for dying individuals has been developed in Mandarin Chinese. Key cultural adaptations were required to ensure that the Chinese version of the i-CODE was sui…
View article: Immune microenvironment and immunotherapy in hepatocellular carcinoma: mechanisms and advances
Immune microenvironment and immunotherapy in hepatocellular carcinoma: mechanisms and advances Open
Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality globally. The tumor microenvironment (TME) plays a pivotal role in HCC progression, characterized by dynamic interactions between stromal components, immune…
View article: Impact and mechanism of problem-solving therapy on self-efficacy in elderly depression with type 2 diabetes (PRIORITY): Study protocol for a feasibility randomised controlled trial
Impact and mechanism of problem-solving therapy on self-efficacy in elderly depression with type 2 diabetes (PRIORITY): Study protocol for a feasibility randomised controlled trial Open
Background Problem-Solving Therapy (PST) has demonstrated potential in improving emotional regulation and self-efficacy by helping patients develop practical solutions to daily challenges. This approach shows promise in the management of m…
View article: The Effect of Electroacupuncture on Microcirculation in Patients With Hypertension and Cognitive Impairment: Protocol for a Multicenter Randomized Controlled Trial (Preprint)
The Effect of Electroacupuncture on Microcirculation in Patients With Hypertension and Cognitive Impairment: Protocol for a Multicenter Randomized Controlled Trial (Preprint) Open
BACKGROUND Hypertension is a significant risk factor for cardiovascular diseases and is associated with an increased risk of mild cognitive impairment (MCI). The lack of effective treatment for these conditions underscores the urgent need…
View article: Study on the mechanism of acupuncture to improve mild cognitive impairment in hypertension by regulating intestinal microbiome
Study on the mechanism of acupuncture to improve mild cognitive impairment in hypertension by regulating intestinal microbiome Open
High blood pressure is a significant risk factor for cardiovascular diseases and is linked to an increased risk of mild cognitive impairment (MCI). The lack of effective treatments for these conditions highlights the urgent need for novel …
View article: Correlation between differences in the intestinal flora structure and Chinese medicine evidence in patients with Wilson disease-related liver fibrosis analyzed via high-throughput sequencing technology
Correlation between differences in the intestinal flora structure and Chinese medicine evidence in patients with Wilson disease-related liver fibrosis analyzed via high-throughput sequencing technology Open
To observe the composition and abundance of the intestinal flora in patients with Wilson disease (WD)-related liver fibrosis and analyze the correlation between the composition of intestinal flora of patients and the evolution of evidence …
View article: Basal cell of origin resolves neuroendocrine–tuft lineage plasticity in cancer
Basal cell of origin resolves neuroendocrine–tuft lineage plasticity in cancer Open
Summary paragraph Neuroendocrine and tuft cells are rare, chemosensory epithelial lineages defined by expression of ASCL1 and POU2F3 transcription factors, respectively 1,2 . Neuroendocrine cancers, including small cell lung cancer (SCLC),…
View article: Four closed characteristics on compact star-shaped hypersurfaces in $\mathbb{R}^{8}$
Four closed characteristics on compact star-shaped hypersurfaces in $\mathbb{R}^{8}$ Open
In this paper, we proved that for every non-degenerate $C^3$ compact star-shaped hypersurface $Σ$ in $\mathbb{R}^{8}$ which carries no prime closed characteristic of Maslov-type index $-1$, there exist at least four prime closed characteri…
View article: [<i>Huangpu Tongqiao</i> Capsule improves cognitive impairment in rats with Wilson disease by inhibiting endoplasmic reticulum stress-mediated apoptosis pathway].
[<i>Huangpu Tongqiao</i> Capsule improves cognitive impairment in rats with Wilson disease by inhibiting endoplasmic reticulum stress-mediated apoptosis pathway]. Open
HPTQ Capsule has neuroprotective effects in rat models of WD possibly by inhibiting ERS-mediated apoptosis pathway.
View article: Pharmacodynamic material basis and mechanism of Tenghuang Jiangu Wan on osteoarthritis using UPLC-Q-TOF-MS integrated with target network pharmacology
Pharmacodynamic material basis and mechanism of Tenghuang Jiangu Wan on osteoarthritis using UPLC-Q-TOF-MS integrated with target network pharmacology Open
Tenghuang Jiangu Wan (THJGW) is a commonly utilized treatment for osteoarthritis (OA), yet its pharmacodynamic material basis and molecular mechanism remain inadequately understood. This study systematically characterized the in vitro and …
View article: Issue Information
Issue Information Open
No abstract is available for this article.
View article: XAF1 promotes colorectal cancer metastasis via VCP–RNF114–JUP axis
XAF1 promotes colorectal cancer metastasis via VCP–RNF114–JUP axis Open
Metastasis is the main cause of colorectal cancer (CRC)-related death, and the 5-year relative survival rate for CRC patients with distant metastasis is only 14%. X-linked inhibitor of apoptosis (XIAP)-associated factor 1 (XAF1) is a zinc-…
View article: Omic horizon expression: a database of gene expression based on RNA sequencing data
Omic horizon expression: a database of gene expression based on RNA sequencing data Open
Background Gene expression profiles have important significance for gene expression characteristics and further functional studies. More attention has been given to the expression databases in humans and mice, but less attention has been g…
View article: PPDPF suppresses the development of hepatocellular carcinoma through TRIM21-mediated ubiquitination of RIPK1
PPDPF suppresses the development of hepatocellular carcinoma through TRIM21-mediated ubiquitination of RIPK1 Open
Pancreatic progenitor cell differentiation and proliferation factor (PPDPF) has been reported to play a role in tumorigenesis. However, its function in hepatocellular carcinoma (HCC) remains poorly understood. In this study, we report that…
View article: Additional file 5 of PES1 reduces CD8+ T cell infiltration and immunotherapy sensitivity via interrupting ILF3-IL15 complex in esophageal squamous cell carcinoma
Additional file 5 of PES1 reduces CD8+ T cell infiltration and immunotherapy sensitivity via interrupting ILF3-IL15 complex in esophageal squamous cell carcinoma Open
Additional file 5. Additional dataset S4.