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View article: Disulfide Crosslinking Induces Rapid Degradation of Arc/Arg3.1 via Hsp70-Mediated Ubiquitin Ligase Pathway
Disulfide Crosslinking Induces Rapid Degradation of Arc/Arg3.1 via Hsp70-Mediated Ubiquitin Ligase Pathway Open
Activity-regulated cytoskeleton-associated protein (Arc/Arg3.1) is an immediate-early gene (IEG) induced by stress and synaptic activity, characterized by transient expression and rapid degradation. However, the mechanisms governing its de…