Damian Holliman
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View article: The clinical and cost-effectiveness of sertraline in preventing depression in adults following a traumatic brain injury (STOP-D): study protocol for a multi-centre randomised controlled trial
The clinical and cost-effectiveness of sertraline in preventing depression in adults following a traumatic brain injury (STOP-D): study protocol for a multi-centre randomised controlled trial Open
This study is registered in the European Union Drug Regulating Authorities Clinical Trials Database (EudraCT no. 2022-000072-18, date: 7 January 2022) and the ISRCTN - The UK's Clinical Study Registry (ISRCTN no. 17518945, date: 23 Decembe…
View article: Elevated glioma-related cortical glutamate <i>in vivo</i> is associated with <i>ex vivo</i> interictal discharges in human brain slices
Elevated glioma-related cortical glutamate <i>in vivo</i> is associated with <i>ex vivo</i> interictal discharges in human brain slices Open
Gliomas are the most common type of malignant brain tumour and are frequently associated with seizures. Seizures associated with gliomas are frequently refractory to conventional antiseizure medications and constitute a significant cause o…
View article: Specialist healthcare services for concussion/mild traumatic brain injury in England: a consensus statement using modified Delphi methodology
Specialist healthcare services for concussion/mild traumatic brain injury in England: a consensus statement using modified Delphi methodology Open
Objective To establish a consensus on the structure and process of healthcare services for patients with concussion in England to facilitate better healthcare quality and patient outcome. Design This consensus study followed the modified D…
View article: Evaluation of Outcomes Among Patients With Traumatic Intracranial Hypertension Treated With Decompressive Craniectomy vs Standard Medical Care at 24 Months
Evaluation of Outcomes Among Patients With Traumatic Intracranial Hypertension Treated With Decompressive Craniectomy vs Standard Medical Care at 24 Months Open
ISRCTN Identifier: 66202560.
View article: Intracerebral schwannoma of the angular gyrus: case report
Intracerebral schwannoma of the angular gyrus: case report Open
We report an intracerebral schwannoma originating in the angular gyrus of a 20-year-old female that was incidentally diagnosed after she presented with a post-traumatic seizure. After comprehensive investigations, including functional magn…
View article: Second Surgery for Progressive Glioblastoma: A Multi-Centre Questionnaire and Cohort-Based Review of Clinical Decision-Making and Patient Outcomes in Current Practice
Second Surgery for Progressive Glioblastoma: A Multi-Centre Questionnaire and Cohort-Based Review of Clinical Decision-Making and Patient Outcomes in Current Practice Open
PurposeGlioblastoma prognosis is poor. Treatment options are limited at progression. Surgery may benefit, but no quality guidelines exist to inform patient selection. We sought to describe variations in surgical management at progression, …
View article: Management evaluation of metastasis in the brain (MEMBRAIN)—a United Kingdom and Ireland prospective, multicenter observational study
Management evaluation of metastasis in the brain (MEMBRAIN)—a United Kingdom and Ireland prospective, multicenter observational study Open
Background In recent years an increasing number of patients with cerebral metastasis (CM) have been referred to the neuro-oncology multidisciplinary team (NMDT). Our aim was to obtain a national picture of CM referrals to assess referral v…
View article: Perampanel and decanoic acid show synergistic action against <scp>AMPA</scp> receptors and seizures
Perampanel and decanoic acid show synergistic action against <span>AMPA</span> receptors and seizures Open
Summary Perampanel is an adjunctive treatment for epilepsy that works through the direct inhibition of AMPA receptors. The same molecular mechanism has recently been shown for a fatty acid, decanoic acid, prescribed in the medium chain tri…
View article: Bypassing nearest hospital for more distant neuroscience care in head-injured adults with suspected traumatic brain injury: findings of the head injury transportation straight to neurosurgery (HITS-NS) pilot cluster randomised trial
Bypassing nearest hospital for more distant neuroscience care in head-injured adults with suspected traumatic brain injury: findings of the head injury transportation straight to neurosurgery (HITS-NS) pilot cluster randomised trial Open
Objective Reconfiguration of trauma services, with direct transport of patients with traumatic brain injury (TBI) to specialist neuroscience centres (SNCs)—bypassing non-specialist acute hospitals (NSAHs), could improve outcomes. However, …
View article: Residual enhancing disease after surgery for glioblastoma: evaluation of practice in the United Kingdom
Residual enhancing disease after surgery for glioblastoma: evaluation of practice in the United Kingdom Open
Background A growing body of clinical data highlights the prognostic importance of achieving gross total resection (GTR) in patients with glioblastoma. The aim of this study was to determine nationwide practice and attitudes towards achiev…
View article: The Head Injury Transportation Straight to Neurosurgery (HITS-NS) randomised trial: a feasibility study
The Head Injury Transportation Straight to Neurosurgery (HITS-NS) randomised trial: a feasibility study Open
Background Reconfiguration of trauma services, with direct transport of traumatic brain injury (TBI) patients to neuroscience centres (NCs), bypassing non-specialist acute hospitals (NSAHs), could potentially improve outcomes. However, del…