Damian M. Bailey
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View article: Mission to Mars: how space exploration pushes the human body to its limits
Mission to Mars: how space exploration pushes the human body to its limits Open
View article: Can Artificial Intelligence Revolutionise Surgical Decision-Making for Appendectomy? A Narrative Review
Can Artificial Intelligence Revolutionise Surgical Decision-Making for Appendectomy? A Narrative Review Open
Introduction Acute appendicitis is a common cause of acute abdomen in secondary care. Despite advancements in diagnostics, misdiagnosis and negative appendectomies remain significant. Artificial Intelligence (AI), particularly machine lear…
View article: Socio‐economic deprivation and functional exercise capacity: a retrospective observational cohort study
Socio‐economic deprivation and functional exercise capacity: a retrospective observational cohort study Open
View article: Watching the eye with Mars in sight
Watching the eye with Mars in sight Open
View article: Access to pediatric extracorporeal membrane oxygenation according to neighborhood-level determinants of health
Access to pediatric extracorporeal membrane oxygenation according to neighborhood-level determinants of health Open
Unequal geographic distribution of neighborhood resources and healthcare services can exacerbate disparities in access to care. In this study, we evaluate geospatial access to pediatric extracorporeal membrane oxygenation (ECMO) services i…
View article: Heart failure‐related elevation of carbohydrate antigen 125 identified by pre‐operative cardiopulmonary exercise testing
Heart failure‐related elevation of carbohydrate antigen 125 identified by pre‐operative cardiopulmonary exercise testing Open
Summary Heart failure is a major peri‐operative risk factor associated with significant postoperative morbidity and mortality. Traditional biomarkers used in heart failure management include natriuretic peptides. Carbohydrate antigen 125 b…
View article: Science of omics: a molecular space odyssey
Science of omics: a molecular space odyssey Open
International audience
View article: Artificial intelligence in colorectal surgery multidisciplinary team approach—From innovation to application
Artificial intelligence in colorectal surgery multidisciplinary team approach—From innovation to application Open
Artificial intelligence (AI) has played a novel role in aiding healthcare system functions and enhancing the patient experience. Multidisciplinary teams (MDT) have become an integral part of disease and management planning, especially with…
View article: Decoding the space integrome: Personalized countermeasures for a mission to Mars
Decoding the space integrome: Personalized countermeasures for a mission to Mars Open
View article: Physiology of bridging stent grafts after fenestrated/branched endovascular aortic repair: Where translational science meets the clinical profile
Physiology of bridging stent grafts after fenestrated/branched endovascular aortic repair: Where translational science meets the clinical profile Open
Fenestrated/branched endovascular aortic repair emerges as the primary therapeutic modality for intricate aortic pathologies encompassing the paravisceral and thoracoabdominal segments, where bridging stent grafts (BSGs) play a vital role …
View article: Phosphodiesterase inhibition restores hypoxia-induced cerebrovascular dysfunction subsequent to improved systemic redox homeostasis: A randomized, double-blind, placebo-controlled crossover study
Phosphodiesterase inhibition restores hypoxia-induced cerebrovascular dysfunction subsequent to improved systemic redox homeostasis: A randomized, double-blind, placebo-controlled crossover study Open
To what extent sildenafil, a selective inhibitor of the type-5 phosphodiesterase modulates systemic redox status and cerebrovascular function during acute exposure to hypoxia remains unknown. To address this, 12 healthy males (aged 24 ± 3 …
View article: Iliac branch endoprosthesis for endovascular treatment of complex aorto‐iliac aneurysms – from device design to practical experience: how to translate physiology considerations into clinical applications
Iliac branch endoprosthesis for endovascular treatment of complex aorto‐iliac aneurysms – from device design to practical experience: how to translate physiology considerations into clinical applications Open
This article provides a narrative review of the current literature and our expert opinion concerning the iliac branch endoprosthesis (IBE) and its use in the treatment of complex abdominal aortic aneurysm (AAA) cases with concomitant aneur…
View article: Respiratory system responses to a maximal apnoea
Respiratory system responses to a maximal apnoea Open
A maximal apnoea provides significant challenges to one's physiological systems, including significantly altered arterial blood gases, and requires a highly integrative response from multiple systems, that is, changes in blood pressure, ma…
View article: Spinal pain prevalence and associated determinants: A population‐based study using the National Survey for Wales
Spinal pain prevalence and associated determinants: A population‐based study using the National Survey for Wales Open
Spinal pain (SP) remains the leading cause of disability worldwide. The present study aimed to establish a current prevalence of SP and associated determinants in Wales by retrospectively analyzing data from the National Survey for Wales D…
View article: Effect of Sarcobesity Index and Body Adipose Tissue Variables on Cardiopulmonary Exercise Testing Performance in Colorectal Surgery Setting: A Retrospective Cohort Study
Effect of Sarcobesity Index and Body Adipose Tissue Variables on Cardiopulmonary Exercise Testing Performance in Colorectal Surgery Setting: A Retrospective Cohort Study Open
Aims/Background The prognostic significance of body composition variables has become a popular area of research over the recent years. This study aimed to determine whether adipose tissue variables and sarcobesity index measured by compute…
View article: Left ventricular unloading to facilitate ventricular remodelling in heart failure: A narrative review of mechanical circulatory support
Left ventricular unloading to facilitate ventricular remodelling in heart failure: A narrative review of mechanical circulatory support Open
Heart failure represents a dynamic clinical challenge with the continuous rise of a multi‐morbid and ageing population. Yet, the evolving nature of mechanical circulatory support offers a variety of means to manage candidates who might ben…
View article: Advancing physiology through transparency: Celebrating our first registered report
Advancing physiology through transparency: Celebrating our first registered report Open
View article: Physiological influences on neurovascular coupling: A systematic review of multimodal imaging approaches and recommendations for future study designs
Physiological influences on neurovascular coupling: A systematic review of multimodal imaging approaches and recommendations for future study designs Open
In this review, we have amalgamated the literature, taking a multimodal neuroimaging approach to quantify the relationship between neuronal firing and haemodynamics during a task paradigm (i.e., neurovascular coupling response), while cons…
View article: Neurovascular coupling methods in healthy individuals using transcranial doppler ultrasonography: A systematic review and consensus agreement
Neurovascular coupling methods in healthy individuals using transcranial doppler ultrasonography: A systematic review and consensus agreement Open
Neurovascular coupling (NVC) is the perturbation of cerebral blood flow (CBF) to meet varying metabolic demands induced by various levels of neural activity. NVC may be assessed by Transcranial Doppler ultrasonography (TCD), using task act…
View article: Evidence for direct <scp>CO<sub>2</sub></scp>‐mediated alterations in cerebral oxidative metabolism in humans
Evidence for direct <span>CO<sub>2</sub></span>‐mediated alterations in cerebral oxidative metabolism in humans Open
Aim How the cerebral metabolic rates of oxygen and glucose utilization (CMRO 2 and CMR Glc , respectively) are affected by alterations in arterial PCO 2 (PaCO 2 ) is equivocal and therefore was the primary question of this study. Methods T…
View article: A prospective longitudinal study of risk factors for abdominal aortic aneurysm
A prospective longitudinal study of risk factors for abdominal aortic aneurysm Open
The aim of this study was to identify risk factors for abdominal aortic aneurysm (AAA) from the largest Welsh screening cohort to date. Patients were recruited from 1993 (to 2015) as part of the South East Wales AAA screening programme thr…
View article: Aortic dissection: Indecision and delays are the parents of physiological failure
Aortic dissection: Indecision and delays are the parents of physiological failure Open
A recent publication in a national newspaper in the UK reported the sudden and unexpected death of an apparently fit and well 50-year-old female returning from holiday after complaining of chest pain as the plane began its descent to land …
View article: Race and ethnicity in physiological research: When socio‐political constructs and biology collide
Race and ethnicity in physiological research: When socio‐political constructs and biology collide Open
In biological taxonomy, the term species refers to a group of similar organisms that can only reproduce with each other, while the term race lacks a consistent definition. Genetically and biologically, Homo sapiens is a single species with…
View article: Death by nitrogen anoxia: On the integrated physiology of human execution
Death by nitrogen anoxia: On the integrated physiology of human execution Open
In opposition to any stated opinion that the death penalty and state execution are somehow humane, we demonstrate herein that the latest method, nitrogen anoxia, invoked by the state of Alabama is inherently inhumane. From a respiratory an…
View article: Experimental bed rest as a model to investigate mechanisms of, and countermeasures against, microgravity and disease‐free inactivity
Experimental bed rest as a model to investigate mechanisms of, and countermeasures against, microgravity and disease‐free inactivity Open
More humans are now entering space than ever before, owing to significant investment from governmental and commercial agencies looking ambitiously to expand the reach of humanity beyond low Earth orbit, involving habitation of a permanent …
View article: Cognition is selectively impaired in males with spinal pain: A retrospective analysis of data from the Longitudinal Study of Ageing Danish Twins
Cognition is selectively impaired in males with spinal pain: A retrospective analysis of data from the Longitudinal Study of Ageing Danish Twins Open
Cognitive decline and spinal pain (back pain [BP] and neck pain [NP]) represent a major public health challenge, yet the potential relationship between them remains elusive. A retrospective analysis of the Longitudinal Study of Ageing Dani…
View article: Severe hypoxaemic hypercapnia compounds cerebral oxidative–nitrosative stress during extreme apnoea: Implications for cerebral bioenergetic function
Severe hypoxaemic hypercapnia compounds cerebral oxidative–nitrosative stress during extreme apnoea: Implications for cerebral bioenergetic function Open
We examined the extent to which apnoea‐induced extremes of oxygen demand/carbon dioxide production impact redox regulation of cerebral bioenergetic function. Ten ultra‐elite apnoeists (six men and four women) performed two maximal dry apno…
View article: Celebrating a decade of sound science: <i>Physiological Reports</i>
Celebrating a decade of sound science: <i>Physiological Reports</i> Open
It is a pleasure for us as Editors-in-Chief of The Physiological Society sister journals to offer some comments in celebration of the 10th anniversary of the publication of Physiological Reports. One of us (KEB) was a member of the Publica…
View article: Acute hypoxia impairs posterior cerebral bioenergetics and memory in man
Acute hypoxia impairs posterior cerebral bioenergetics and memory in man Open
Hypoxia has the potential to impair cognitive function; however, it is still uncertain which cognitive domains are adversely affected. We examined the effects of acute hypoxia (∼7 h) on central executive (Go/No‐Go) and non‐executive (memor…
View article: Burning fuels burns the brain's bioenergetic bridges: On the importance of physiological resilience
Burning fuels burns the brain's bioenergetic bridges: On the importance of physiological resilience Open
Anthropogenic climate change will be among our greatest challenges this century. At current global temperatures of 1.1°C above pre-industrial averages, 75% of hot weather extremes and 18% of heavy precipitation events are attributable to g…