Damien Bégué
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View article: Modeling Blazar Broadband Emission with Convolutional Neural Networks. III. Proton Synchrotron and Hybrid Models
Modeling Blazar Broadband Emission with Convolutional Neural Networks. III. Proton Synchrotron and Hybrid Models Open
Modeling the broadband emission of blazars has become increasingly challenging with the advent of multimessenger observations. Building upon previous successes in applying convolutional neural networks (CNNs) to leptonic emission scenarios…
View article: Direct Solution of the Time-Dependent Covariant Radiative Transfer Equation and its Coupling to General Relativistic Magnetohydrodynamics with cuHARM
Direct Solution of the Time-Dependent Covariant Radiative Transfer Equation and its Coupling to General Relativistic Magnetohydrodynamics with cuHARM Open
In this paper we present a major update to the general relativistic magnetohydrodynamics (GRMHD) code cuHARM, which adds fully covariant treatment of radiation transport and the subsequent radiation backreaction on the dynamics of the flui…
View article: Modeling blazar broadband emission with convolutional neural networks -- III. proton synchrotron and hybrid models
Modeling blazar broadband emission with convolutional neural networks -- III. proton synchrotron and hybrid models Open
Modeling the broadband emission of blazars has become increasingly challenging with the advent of multimessenger observations. Building upon previous successes in applying convolutional neural networks (CNNs) to leptonic emission scenarios…
View article: Unraveling the Origins of Gamma-Ray Burst X-Ray Plateaus through a Study of X-Ray Flares
Unraveling the Origins of Gamma-Ray Burst X-Ray Plateaus through a Study of X-Ray Flares Open
The X-ray light curves of gamma-ray bursts (GRBs) display complex features, including plateaus and flares, that challenge theoretical models. Here, we study the properties of flares that are observed in the early afterglow phase (up to a f…
View article: Modelling of the time-resolved spectral energy distribution of blazar OJ 287 from 2008 to 2023: a comprehensive multi-epoch study
Modelling of the time-resolved spectral energy distribution of blazar OJ 287 from 2008 to 2023: a comprehensive multi-epoch study Open
We present a comprehensive analysis of the time-resolved spectral energy distributions (SEDs) of the blazar OJ 287 over a 15-yr period (2008–2023), using multiwavelength data. In the $\gamma$-ray band, multiple flaring episodes were observ…
View article: Radiative cooling changes the dynamics of magnetically arrested disks
Radiative cooling changes the dynamics of magnetically arrested disks Open
We studied magnetically arrested disks (MAD) around rotating black holes (BH), under the influence of radiative cooling. We introduce a critical value of the mass accretion rate $\dot M_{\rm crit}$ for which the cooling by the synchrotron …
View article: Unraveling the Origins of GRB X-ray Plateaus through a Study of X-ray Flares
Unraveling the Origins of GRB X-ray Plateaus through a Study of X-ray Flares Open
The X-ray light curves of gamma-ray bursts (GRBs) display complex features, including plateaus and flares, that challenge theoretical models. Here, we study the properties of flares that are observed in the early afterglow phase (up to a f…
View article: Markarian Multiwavelength Data Center (MMDC): A Tool for Retrieving and Modeling Multitemporal, Multiwavelength, and Multimessenger Data from Blazar Observations
Markarian Multiwavelength Data Center (MMDC): A Tool for Retrieving and Modeling Multitemporal, Multiwavelength, and Multimessenger Data from Blazar Observations Open
The Markarian Multiwavelength Data Center ( MMDC ) is a web-based tool designed for accessing and retrieving multiwavelength and multimessenger data from blazar observations. MMDC facilitates the construction and interactive visualization …
View article: A cereblon (CRBN) molecular glue degrader of NIMA-related kinase 7 (NEK7) reveals a context-dependent role in NLRP3 inflammasome activation
A cereblon (CRBN) molecular glue degrader of NIMA-related kinase 7 (NEK7) reveals a context-dependent role in NLRP3 inflammasome activation Open
Summary The NLRP3 (NACHT-, leucine-rich repeat [LRR]- and pyrin domain [PYD]- containing protein 3) inflammasome is a cytoplasmic signaling complex that promotes inflammation in response to signals from infection and cellular damage. Incre…
View article: Markarian Multiwavelength Data Center (MMDC): A Tool for Retrieving and Modeling Multi-temporal, Multi-wavelength and Multi-messenger Data from Blazar Observations
Markarian Multiwavelength Data Center (MMDC): A Tool for Retrieving and Modeling Multi-temporal, Multi-wavelength and Multi-messenger Data from Blazar Observations Open
The Markarian Multiwavelength Data Center (MMDC) is a web-based tool designed for accessing and retrieving multiwavelength and multimessenger data from blazar observations. MMDC facilitates the construction and interactive visualization of…
View article: Modeling Blazar Broadband Emission with Convolutional Neural Networks. II. External Compton Model
Modeling Blazar Broadband Emission with Convolutional Neural Networks. II. External Compton Model Open
In the context of modeling spectral energy distributions (SEDs) for blazars, we extend the method that uses a convolutional neural network (CNN) to include external inverse Compton processes. The model assumes that relativistic electrons w…
View article: Small molecule induced STING degradation facilitated by the HECT ligase HERC4
Small molecule induced STING degradation facilitated by the HECT ligase HERC4 Open
Stimulator of interferon genes (STING) is a central component of the cytosolic nucleic acids sensing pathway and as such master regulator of the type I interferon response. Due to its critical role in physiology and its’ involvement in a v…
View article: Modeling Blazar Broadband Emission with a Convolutional Neural Network. I. Synchrotron Self-Compton Model
Modeling Blazar Broadband Emission with a Convolutional Neural Network. I. Synchrotron Self-Compton Model Open
Modeling the multiwavelength spectral energy distributions (SEDs) of blazars provides key insights into the underlying physical processes responsible for the emission. While SED modeling with self-consistent models is computationally deman…
View article: Modeling blazar broadband emission with convolutional neural networks -- II. External Compton model
Modeling blazar broadband emission with convolutional neural networks -- II. External Compton model Open
In the context of modeling spectral energy distributions (SEDs) for blazars, we extend the method that uses a convolutional neural network (CNN) to include external inverse Compton processes. The model assumes that relativistic electrons w…
View article: A Study of the Accretion State of Magnetically Arrested Disks across Black Hole Spins for Radiatively Inefficient Accretion Flows
A Study of the Accretion State of Magnetically Arrested Disks across Black Hole Spins for Radiatively Inefficient Accretion Flows Open
The study of magnetically arrested disks (MAD) has attracted strong interest in recent years because these disk configurations were found to generate strong jets, as observed in many accreting systems. Here, we present the results of 14 ge…
View article: DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance
DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance Open
Targeted protein degradation (TPD) mediates protein level through small molecule induced redirection of E3 ligases to ubiquitinate neo-substrates and mark them for proteasomal degradation. TPD has recently emerged as a key modality in drug…
View article: Study accretion and ejection using a new GPU-accelerated GRMHD code
Study accretion and ejection using a new GPU-accelerated GRMHD code Open
We study disks and jets in various accretion states (SANE and MAD) using novel, GPU-accelerated general-relativistic magneto-hydrodynamic (GR-MHD) code which we developed, based on HARM. This code, written in CUDA-c and uses OpenMP to para…
View article: Modeling blazar broadband emission with convolutional neural networks -- I. Synchrotron self-Compton model
Modeling blazar broadband emission with convolutional neural networks -- I. Synchrotron self-Compton model Open
Modeling the multiwavelength spectral energy distributions (SEDs) of blazars provides key insights into the underlying physical processes responsible for the emission. While SED modeling with self-consistent models is computationally deman…
View article: A study of the MAD accretion state across black hole spins for radiatively inefficient accretion flows
A study of the MAD accretion state across black hole spins for radiatively inefficient accretion flows Open
The study of Magnetically Arrested Disks (MAD) attract strong interest in recent years, as these disk configurations were found to generate strong jets as observed in many accreting systems. Here, we present the results of 14 general relat…
View article: Hybrid Emission Modeling of GRB 221009A: Shedding Light on TeV Emission Origins in Long GRBs
Hybrid Emission Modeling of GRB 221009A: Shedding Light on TeV Emission Origins in Long GRBs Open
Observations of long-duration gamma-ray bursts (GRBs) with TeV emission during their afterglow have been on the rise. Recently, GRB 221009A, the most energetic GRB ever observed, was detected by the Large High Altitude Air Shower Observato…
View article: Proton Synchrotron Origin of the Very-high-energy Emission of GRB 190114C
Proton Synchrotron Origin of the Very-high-energy Emission of GRB 190114C Open
We consider here a proton-synchrotron model to explain the MAGIC observation of GRB 190114C afterglow in the energy band of 0.2–1 TeV, while the X-ray spectra are explained by electron-synchrotron emission. Given the uncertainty of the par…
View article: Hybrid Emission Modeling of GRB 221009A: Shedding Light on TeV Emission Origins in Long-GRBs
Hybrid Emission Modeling of GRB 221009A: Shedding Light on TeV Emission Origins in Long-GRBs Open
Observations of long duration gamma-ray bursts (GRBs) with TeV emission during their afterglow have been on the rise. Recently, GRB 221009A, the most energetic GRB ever observed, was detected by the {LHAASO} experiment in the energy band 0…
View article: Probing gamma-ray bursts observed at very high energies through their afterglow
Probing gamma-ray bursts observed at very high energies through their afterglow Open
A growing number of gamma-ray burst (GRB) afterglows is observed at very-high energies (VHE, ≳ 100 GeV). Yet, our understanding of the mechanism powering the VHE emission remains baffling. We make use of multiwavelength observations of the…
View article: Reinstating targeted protein degradation with DCAF1 PROTACs in CRBN PROTAC resistant settings
Reinstating targeted protein degradation with DCAF1 PROTACs in CRBN PROTAC resistant settings Open
Targeted protein degradation (TPD) of neo-substrates with proteolysis targeting chimeras (PROTACs) or molecular glues has emerged as a key modality in exploring new biology as well as designing new drug candidates where catalytic inhibitio…
View article: A novel HERC4-dependent glue degrader targeting STING
A novel HERC4-dependent glue degrader targeting STING Open
Stimulator of interferon genes (STING) is a central component of the pathway sensing the presence of cytosolic nucleic acids, having a key role in type I interferon innate immune response. Localized at the endoplasmic reticulum (ER), STING…
View article: Probing gamma-ray bursts observed at very high energies through their afterglow
Probing gamma-ray bursts observed at very high energies through their afterglow Open
A growing number of gamma-ray burst (GRB) afterglows is observed at very-high energies (VHE, $\gtrsim 100$ GeV). Yet, our understanding of the mechanism powering the VHE emission remains baffling. We make use of multi-wavelength observatio…
View article: cuHARM: A New GPU-accelerated GRMHD Code and Its Application to ADAF Disks
cuHARM: A New GPU-accelerated GRMHD Code and Its Application to ADAF Disks Open
We introduce a new GPU-accelerated general relativistic magnetohydrodynamic code based on HARM, which we call cuHARM. The code is written in CUDA-C and uses OpenMP to parallelize multi-GPU setups. Our code allows us to run high-resolution …