Explanipedia

Safety and Oncologic Outcomes of Endoscopic Endonasal Transcribriform Approach for Locally Advanced Sinonasal Malignancies Open

Michel G. Khalaf, H. De Kermadec, Juliette Hershkovitch, Odile Casiraghi, Gabriel Garcia , et al. · 2025

Introduction The past two decades have seen a paradigm shift in the surgical treatment of sinonasal malignancies, moving from traditional open approaches to minimally invasive endoscopic techniques. Technological advancements have enabled …

International Recommendations on Postoperative Management for Potentially Resectable Locally Recurrent Nasopharyngeal Carcinoma Open

Ji-Shi Li, Pierre Blanchard, Charlene H. L. Wong, Yong Chan Ahn, Pierluigi Bonomo , et al. · 2024

Prognostic value of early EEG abnormalities in severe stroke patients requiring mechanical ventilation: a pre-planned analysis of the SPICE prospective multicenter study Open

Sarah Benghanem, Nathalie Kubis, Étienne Gayat, Ambre Loiodice, Estelle Pruvost‐Robieux , et al. · 2024

Introduction Prognostication of outcome in severe stroke patients necessitating invasive mechanical ventilation poses significant challenges. The objective of this study was to assess the prognostic significance and prevalence of early ele…

Embolization of the middle meningeal artery for the prevention of chronic subdural hematoma recurrence in high-risk patients: a randomized controlled trial—the EMPROTECT study protocol Open

Eimad Shotar, Bertrand Mathon, Aymeric Rouchaud, Charbel Mounayer, Henri Salle , et al. · 2024

Background Middle meningeal artery (MMA) embolization has been proposed as a treatment of chronic subdural hematoma (CSDH). The benefit of the procedure has yet to be demonstrated in a randomized controlled trial. We aim to assess the effi…

Unbiased approach to identify and assess efficacy of human SARS-CoV-2 neutralizing antibodies Open

Xia Cao, Junki Maruyama, Heyue Zhou, Yanwen Fu, Lisa Kerwin , et al. · 2022

Aggressive pituitary tumours and carcinomas, characteristics and management of 171 patients Open

Pia Burman, Jacqueline Trouillas, Marco Losa, Ann McCormack, Stephan Petersenn , et al. · 2022

Objective To describe clinical and pathological characteristics and treatment outcomes in a large cohort of aggressive pituitary tumours (APT)/pituitary carcinomas (PC). Design Electronic survey August 2020–May 2021. Results 96% of 171 (12…

Discovery and intranasal administration of a SARS-CoV-2 broadly acting neutralizing antibody with activity against multiple Omicron subvariants Open

J. Andrew Duty, Thomas Kraus, Heyue Zhou, Yanliang Zhang, Namir Shaabani , et al. · 2022

The endoscopic transnasal approach to the lesions of the craniocervical junction: two case reports Open

Baraa Dabboucy, Wissem Lahiani, Damien Bresson, Nouman Aldahak · 2022

The endoscopic endonasal approach (EEA) to the craniovertebral junction (CVJ) has recently been considered a safer alternative and less invasive approach than the traditional transoral approach because the complications associated with the…

The dural angioleiomyoma harbors frequent GJA4 mutation and a distinct DNA methylation profile Open

Arnault Tauziède‐Espariat, Thibaut Pierre, Michel Wassef, David Castel, Florence Riant , et al. · 2022

The International Society for the Study of Vascular Anomalies (ISSVA) has defined four vascular lesions in the central nervous system (CNS): arteriovenous malformations, cavernous angiomas (also known as cerebral cavernous malformations), …

A Novel Affinity Engineered Anti-CD47 Antibody With Improved Therapeutic Index That Preserves Erythrocytes and Normal Immune Cells Open

Youg Raj Thaker, Ianne Rivera, Christophe Pedros, Alok R. Singh, Laura Rivero-Nava , et al. · 2022

Therapeutic blockade of the CD47/SIRPα axis by small molecules or monoclonal antibodies (mAbs) is a proven strategy to enhance macrophages-mediated anti-tumor activity. However, this strategy has been hampered by elevated on-target toxicit…

Discovery of a SARS-CoV-2 Broadly-Acting Neutralizing Antibody with Activity against Omicron and Omicron + R346K Variants Open

J. Andrew Duty, Thomas Kraus, Heyue Zhou, Yanliang Zhang, Namir Shaabani , et al. · 2022

The continual emergence of SARS-CoV-2 variants of concern, in particular the newly emerged Omicron (B.1.1.529) variant, has rendered ineffective a number of previously EUA approved SARS-CoV-2 neutralizing antibody therapies. Furthermore, e…

Imaging of Skull Base and Orbital Invasion in Sinonasal Cancer: Correlation with Histopathology Open

Maxime Salfrant, Gabriel Garcia, J.-P. Guichard, François Bidault, D Reizine , et al. · 2021

Background: Pretreatment assessment of local extension in sinonasal cancer is essential for prognostic evaluation and surgical planning. The aim of this study was to assess the diagnostic performance of two common imaging techniques (CT an…

Protective Effects of STI-2020 Antibody Delivered Post-Infection by the Intranasal or Intravenous Route in a Syrian Golden Hamster COVID-19 Model Open

Yanwen Fu, Junki Maruyama, Alok Singh, Reyna K. V. Lim, Arthur Ledesma , et al. · 2020

We have previously reported that the SARS-CoV-2 neutralizing antibody, STI-2020, potently inhibits cytopathic effects of infection by genetically diverse clinical SARS-CoV-2 pandemic isolates in vitro, and has demonstrated efficacy in a ha…

Endoscopic Decompression of the Labyrinthine Segment of the Facial Nerve Open

Nicolas Cornu, Daniele Marchioni, Michaël Eliezer, Benjamin Vérillaud, Charlotte Hautefort , et al. · 2020

Objective: To describe the outcome and feasibility of an exclusive endoscopic transcanal transpromontorial approach (ETTA) for decompression of the labyrinthine segment of the facial nerve (LSFN). Patient: A 60-year-old man with a left-sid…

Hybrid Robotics for Endoscopic Skull Base Surgery: Preclinical Evaluation and Surgeon First Impression Open

Francesca Zappa, Davide Mattavelli, Alba Madoglio, Vittorio Rampinelli, Marco Ferrari , et al. · 2019

Predictors of Epileptic Seizures and Ability to Work in Supratentorial Cavernous Angioma Located Within Eloquent Brain Areas Open

Marc Zanello, John Goodden, Henry Colle, Michel Wager, Philip C. De Witt Hamer , et al. · 2019

BACKGROUND The postoperative outcomes and the predictors of seizure control are poorly studied for supratentorial cavernous angiomas (CA) within or close to the eloquent brain area. OBJECTIVE To assess the predictors of preoperative seizur…

Surgery and protontherapy in Grade I and II skull base chondrosarcoma: A comparative retrospective study Open

François Simon, L. Feuvret, Damien Bresson, Jean‐Pierre Guichard, Sophie El Zein , et al. · 2018

Long-term disease specific survival was not significantly lower in patients without adjuvant proton therapy, but they experienced less adverse effects. We believe a surgery only strategy could be discussed, delaying as much as possible pro…

Correction to: A rare presentation of skull-base osteomyelitis with neurovascular sheath extension following external otitis resolved by PET/MRI Open

Nicolas Louarn, Quentin Alias, Laurène Aupin, Nicolas Benoist, Marine Desroches , et al. · 2018

Antibody-drug conjugates: integrated bioanalytical and biodisposition assessments in lead optimization and selection Open

Maribel Beaumont, Daniela M. Tomazela, Douglas Hodges, Grigori Ermakov, Edward J. Hsieh , et al. · 2018

A rare presentation of skull-base osteomyelitis with neurovascular sheath extension following external otitis resolved by PET/MRI Open

Nicolas Louarn, Quentin Alias, Laurène Aupin, Nicolas Benoist, Marine Desroches , et al. · 2018

Treatment of aggressive pituitary tumours and carcinomas: results of a European Society of Endocrinology (ESE) survey 2016 Open

Ann McCormack, Olaf M. Dekkers, Stephan Petersenn, Vera Popović, Jacqueline Trouillas , et al. · 2018

Objective To collect outcome data in a large cohort of patients with aggressive pituitary tumours (APT)/carcinomas (PC) and specifically report effects of temozolomide (TMZ) treatment. Design Electronic survey to ESE members Dec 2015–Nov 2…

Regression of giant olfactory groove meningioma and complete visual acuity recovery after discontinuation of cyproterone acetate Open

Sophie Bonnin, Anne-Laure Bernat, Moujahed Labidi, Nouman Aldahak, Damien Bresson , et al. · 2018

In meningiomas associated with CA, treatment cessation may result in prompt improvement in symptoms and a reduction in tumor volume, even if the tumor is large and causing neurologic impairments.

Functional impairments for outcomes in a randomized trial of unruptured brain AVMs Open

J.P. Mohr, Jessica Overbey, Ruediger von Kummer, Marco Antônio Stefani, Richard Libman , et al. · 2017

This study provides Class II evidence that for adults with unruptured brain AVMs, interventional management compared to MM increases the risk of disability and death over ≈3 years.

Utilisation de matériaux recyclés en voirie et réseaux divers. Qualité des ouvrages du point de vue du maître d’oeuvre Open

Damien Bresson · 2017

The project manager in road and utilities construction has to ensure the quality of these works and the respect of the project owner needs. For both economic and environmental reasons, the use of recycling aggregates is increasing in this …

3D digital subtracted CT angiography to evaluate the venous anatomy in extra-axial tumors invading the major dural venous sinuses Open

Stéphanie Lenck, Damien Bresson, Anne-Laure Bernat, Jean‐Pierre Saint‐Maurice, Marc‐Antoine Labeyrie , et al. · 2017

Background Investigation of the venous system surrounding a tumor that is invading a dural sinus is of great use for guiding the surgical excision. Non-invasive imaging is often inadequate since enhancement of the tumor causes it to blend …

Étude de l’écoulement sanguin dans un anévrysme intracrânien avant et après traitement par stent flow diverter : quantification par traitement d’images de séquences angiographiques 2D Open

Damien Bresson · 2016

Intracranial aneurysms treatment based on intra aneurismal flow modification tend to replace traditionally coiling in many cases and not only complex aneurysms for which they were initially designed. Dedicated stents (low porosity, high po…

Erratum to: Outcome of a cohort of severe cerebral venous thrombosis in intensive care Open

Benjamin Soyer, Marco Rusca, Anne‐Claire Lukaszewicz, Isabelle Crassard, Jean‐Pierre Guichard , et al. · 2016

Neuronavigated Fiber Dissection with Pial Preservation: Laboratory Model to Simulate Opercular Approaches to Insular Tumors Open

Emmanuel Mandonnet, Juan Martino, Silvio Sarubbo, Francesco Corrivetti, S. Bouazza , et al. · 2016

Outcome of a cohort of severe cerebral venous thrombosis in intensive care Open

Benjamin Soyer, Marco Rusca, Anne‐Claire Lukaszewicz, Isabelle Crassard, Jean‐Pierre Guichard , et al. · 2016

Prognostic and Therapeutic Markers in Chordomas: A Study of 287 Tumors Open

Arnault Tauziède‐Espariat, Damien Bresson, Marc Polivka, S. Bouazza, François Labrousse , et al. · 2016

Chordomas are slow-growing malignant neoplasms. Determination of histopathologic prognostic factors using a large cohort study has been limited by their low incidence. In this retrospective study, we investigated the clinical, histopatholo…

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