Damien M. Laudier
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View article: Endoneurial damage is associated with chronic dysfunction and neuroma formation after stretch injury in the rat median nerve
Endoneurial damage is associated with chronic dysfunction and neuroma formation after stretch injury in the rat median nerve Open
The neuroclasis classification might be helpful in developing novel diagnostic tools and evaluating the prognosis for recovery and need for surgical treatment. This study further highlights a potential need for different classification sys…
View article: Functional anatomy of the sharpshooter precibarial valve supports its role in probing behaviors that control inoculation of Xylella fastidiosa
Functional anatomy of the sharpshooter precibarial valve supports its role in probing behaviors that control inoculation of Xylella fastidiosa Open
The precibarial valve is a tiny structure in the functional foregut (cibarium and precibarium) of hemipteran insects. Piercing-sucking insects like hemipterans use straw-like mouth parts (stylets) to ingest fluid from plant vascular cells …
View article: <scp>TNFα</scp> Receptor 1 and Not Receptor 2 Affect Annulus Fibrosus and Nucleus Pulposus Response to Cytokine Challenge in a Rat Model
<span>TNFα</span> Receptor 1 and Not Receptor 2 Affect Annulus Fibrosus and Nucleus Pulposus Response to Cytokine Challenge in a Rat Model Open
Background Painful intervertebral disc (IVD) degeneration (IVDD) involves chronic inflammation. Developing translational immunomodulatory strategies for IVDD is a priority with tumor necrosis factor alpha (TNFα) signaling an important targ…
View article: Tendon Inversion Improves Tendon-to-Bone Healing in a Rat Bicep Tenodesis Model
Tendon Inversion Improves Tendon-to-Bone Healing in a Rat Bicep Tenodesis Model Open
Purpose Tendon- or ligament-to-bone repair remains a surgical challenge. While bone tunnel fixation is a common surgical technique whereby soft tissue is expected to heal against a bone tunnel interface, contemporary methods have yet to re…
View article: TNFR1-mediated senescence and lack of TNFR2-signaling limit human intervertebral disc cell repair in back pain conditions
TNFR1-mediated senescence and lack of TNFR2-signaling limit human intervertebral disc cell repair in back pain conditions Open
Poor intervertebral disc (IVD) healing causes IVD degeneration (IVDD) and progression to herniation and back pain. This study identified distinct roles of TNFα-receptors (TNFRs) in contributing to poor healing in painful IVDD. We first iso…
View article: Annulus Fibrosus Injury Induces Acute Neuroinflammation and Chronic Glial Response in Dorsal Root Ganglion and Spinal Cord—An In Vivo Rat Discogenic Pain Model
Annulus Fibrosus Injury Induces Acute Neuroinflammation and Chronic Glial Response in Dorsal Root Ganglion and Spinal Cord—An In Vivo Rat Discogenic Pain Model Open
Chronic painful intervertebral disc (IVD) degeneration (i.e., discogenic pain) is a major source of global disability needing improved knowledge on multiple-tissue interactions and how they progress in order improve treatment strategies. T…
View article: Galectin‐3 and RAGE differentially control advanced glycation endproduct‐induced collagen damage in murine intervertebral disc organ culture
Galectin‐3 and RAGE differentially control advanced glycation endproduct‐induced collagen damage in murine intervertebral disc organ culture Open
Background Back and neck pain are leading causes of global disability that are associated with intervertebral disc (IVD) degeneration. Causes of IVD degeneration are multifactorial, and diet, age, and diabetes have all been linked to IVD d…
View article: Spinal Cord Sensitization and Spinal Inflammation from an In Vivo Rat Endplate Injury Associated with Painful Intervertebral Disc Degeneration
Spinal Cord Sensitization and Spinal Inflammation from an In Vivo Rat Endplate Injury Associated with Painful Intervertebral Disc Degeneration Open
Intervertebral disc (IVD) degeneration with Modic-like changes is strongly associated with pain. Lack of effective disease-modifying treatments for IVDs with endplate (EP) defects means there is a need for an animal model to improve unders…
View article: Lumbar endplate microfracture injury induces Modic-like changes, intervertebral disc degeneration and spinal cord sensitization – An In Vivo Rat Model
Lumbar endplate microfracture injury induces Modic-like changes, intervertebral disc degeneration and spinal cord sensitization – An In Vivo Rat Model Open
BACKGROUND CONTEXT : Endplate (EP) injury plays critical roles in painful IVD degeneration since Modic changes (MCs) are highly associated with pain. Models of EP microfracture that progress to painful conditions are needed to better under…
View article: Wnt7a Suppresses Adipogenesis of Skeletal Muscle Mesenchymal Stem Cells and Fatty Infiltration Through the Alternative Wnt-Rho-YAP/TAZ Signaling Axis
Wnt7a Suppresses Adipogenesis of Skeletal Muscle Mesenchymal Stem Cells and Fatty Infiltration Through the Alternative Wnt-Rho-YAP/TAZ Signaling Axis Open
Intramuscular fatty infiltration in muscle injuries and diseases, caused by aberrant adipogenesis of fibro-adipogenic progenitors, negatively impacts function. Intramuscular delivery of Wnt7a offers a promising strategy to stimulate muscle…
View article: High fat diet causes inferior vertebral structure and function without disc degeneration in RAGE‐KO mice
High fat diet causes inferior vertebral structure and function without disc degeneration in RAGE‐KO mice Open
Back pain and spinal pathologies are associated with obesity in juveniles and adults, yet studies identifying causal relationships are lacking and none investigate sex differences. This study determined if high fat (HF) diet causes structu…
View article: Histological Atlas of the Internal Anatomy of Female <i>Varroa destructor</i> (Mesostigmata: Varroidae) Mites in Relation to Feeding and Reproduction
Histological Atlas of the Internal Anatomy of Female <i>Varroa destructor</i> (Mesostigmata: Varroidae) Mites in Relation to Feeding and Reproduction Open
Histochemical staining of histological sections of Varroa destructor (Anderson and Trueman, 2000) mites reveal the internal body plan and are used to contrast the internal organs associated with feeding and reproduction of starved versus r…
View article: Spatial mapping of collagen content and structure in human intervertebral disk degeneration
Spatial mapping of collagen content and structure in human intervertebral disk degeneration Open
Collagen plays a key structural role in both the annulus fibrosus (AF) and nucleus pulposus (NP) of intervertebral disks (IVDs). Changes in collagen content with degeneration suggest a shift from collagen type II to type I within the NP, a…
View article: Advanced glycation end products cause <scp>RAGE</scp>‐dependent annulus fibrosus collagen disruption and loss identified using in situ second harmonic generation imaging in mice intervertebral disk in vivo and in organ culture models
Advanced glycation end products cause <span>RAGE</span>‐dependent annulus fibrosus collagen disruption and loss identified using in situ second harmonic generation imaging in mice intervertebral disk in vivo and in organ culture models Open
Aging and diabetes are associated with increased low‐back pain and intervertebral disk (IVD) degeneration yet causal mechanisms remain uncertain. Advanced glycation end products (AGEs), which accumulate in IVDs from aging and are implicate…
View article: Cell lineage tracing and functional assessment of supraspinatus tendon healing in an acute repair murine model
Cell lineage tracing and functional assessment of supraspinatus tendon healing in an acute repair murine model Open
Rotator cuff supraspinatus tendon injuries are common with high rates of anatomic failure after surgical repair. The purpose of the study was to define clinically relevant features of a mouse model of supraspinatus tendon injury to determi…
View article: Correction: Dietary polyphenols as a safe and novel intervention for modulating pain associated with intervertebral disc degeneration in an in-vivo rat model
Correction: Dietary polyphenols as a safe and novel intervention for modulating pain associated with intervertebral disc degeneration in an in-vivo rat model Open
[This corrects the article DOI: 10.1371/journal.pone.0223435.].
View article: Dietary polyphenols as a safe and novel intervention for modulating pain associated with intervertebral disc degeneration in an in-vivo rat model
Dietary polyphenols as a safe and novel intervention for modulating pain associated with intervertebral disc degeneration in an in-vivo rat model Open
Developing effective therapies for back pain associated with intervertebral disc (IVD) degeneration is a research priority since it is a major socioeconomic burden and current conservative and surgical treatments have limited success. Poly…
View article: Composite biomaterial repair strategy to restore biomechanical function and reduce herniation risk in an ex vivo large animal model of intervertebral disc herniation with varying injury severity
Composite biomaterial repair strategy to restore biomechanical function and reduce herniation risk in an ex vivo large animal model of intervertebral disc herniation with varying injury severity Open
Back pain commonly arises from intervertebral disc (IVD) damage including annulus fibrosus (AF) defects and nucleus pulposus (NP) loss. Poor IVD healing motivates developing tissue engineering repair strategies. This study evaluated a comp…
View article: Composite biomaterial repair strategy to restore biomechanical function and reduce herniation risk in an ex vivo large animal model of intervertebral disc herniation with varying injury severity
Composite biomaterial repair strategy to restore biomechanical function and reduce herniation risk in an ex vivo large animal model of intervertebral disc herniation with varying injury severity Open
Back pain commonly arises from intervertebral disc (IVD) damage including annulus fibrosus (AF) defects and nucleus pulposus (NP) loss. Poor IVD healing motivates developing tissue engineering repair strategies. This study evaluated a comp…
View article: Genetic lineage tracing of targeted cell populations during enthesis healing
Genetic lineage tracing of targeted cell populations during enthesis healing Open
Rotator cuff supraspinatus tendon injuries are clinically challenging due to the high rates of failure after surgical repair. One key limitation to functional healing is the failure to regenerate the enthesis transition between tendon and …