Damilola D. Adingupu
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View article: SGLT2 inhibition improves coronary flow velocity reserve and contractility: role of glucagon signaling
SGLT2 inhibition improves coronary flow velocity reserve and contractility: role of glucagon signaling Open
Background SGLT2 inhibitors, a T2DM medication to lower blood glucose, markedly improve cardiovascular outcomes but the underlying mechanism(s) are not fully understood. SGLT2i’s produce a unique metabolic pattern by lowering blood glucose…
View article: Issue Information
Issue Information Open
Wiley is a founding member of the UN-backed HINARI, AGORA, and OARE initiatives.They are now collectively known as Research4Life, making online scientific content available free or at nominal cost to researchers in developing countries.
View article: Brain hypoxia, neurocognitive impairment, and quality of life in people post-COVID-19
Brain hypoxia, neurocognitive impairment, and quality of life in people post-COVID-19 Open
Objective Systemic hypoxia occurs in COVID-19 infection; however, it is unknown if cerebral hypoxia occurs in convalescent individuals. We have evidence from other conditions associated with central nervous system inflammation that hypoxia…
View article: Cerebral small vessel disease, systemic vascular characteristics and potential therapeutic targets
Cerebral small vessel disease, systemic vascular characteristics and potential therapeutic targets Open
In addition to hypertension, microalbuminuria, arterial stiffness, vascular reactivity and cerebrovascular resistance could be potential treatment targets to halt the development or progression of cerebral SVD.
View article: Intestinal sodium/glucose cotransporter 3 expression is epithelial and downregulated in obesity
Intestinal sodium/glucose cotransporter 3 expression is epithelial and downregulated in obesity Open
Our study shows that Sglt3a/3b is expressed primarily in epithelial cells of the small intestine in mice. Furthermore, we observed an association between intestinal mRNA Sglt3a/3b expression and obesity in mice, and between jejunal SGLT3 p…
View article: Weight change and sulfonylurea therapy are related to 3 year change in microvascular function in people with type 2 diabetes
Weight change and sulfonylurea therapy are related to 3 year change in microvascular function in people with type 2 diabetes Open
View article: P17 Comparisons of Carotid-femoral Pulse Wave Velocity Obtained from the Surface-distance Measurement and from the Population-derived Distance Formula: Associations with Macro- and Microvascular Alterations in Older Adults
P17 Comparisons of Carotid-femoral Pulse Wave Velocity Obtained from the Surface-distance Measurement and from the Population-derived Distance Formula: Associations with Macro- and Microvascular Alterations in Older Adults Open
Introduction Inaccurate determination of arterial path-length by surface-distance (SD) measurement is an inherent source of error in calculating carotid-femoral pulse wave velocity (CFPWV). A recent development in calculating arterial path…
View article: SGLT2 inhibition with empagliflozin improves coronary microvascular function and cardiac contractility in prediabetic ob/ob−/− mice
SGLT2 inhibition with empagliflozin improves coronary microvascular function and cardiac contractility in prediabetic ob/ob−/− mice Open
View article: The impact of cardiovascular co-morbidities and duration of diabetes on the association between microvascular function and glycaemic control
The impact of cardiovascular co-morbidities and duration of diabetes on the association between microvascular function and glycaemic control Open
View article: P4339SGLT2 inhibition improves coronary microvascular function and contractile function in pre-diabetic mice
P4339SGLT2 inhibition improves coronary microvascular function and contractile function in pre-diabetic mice Open
View article: Radial artery intima-media thickness regresses after secondary prevention interventions in patients’ post-acute coronary syndrome and is associated with cardiac and kidney biomarkers
Radial artery intima-media thickness regresses after secondary prevention interventions in patients’ post-acute coronary syndrome and is associated with cardiac and kidney biomarkers Open
rIMT seem to decrease systemically after ACS and is accompanied with corresponding biomarker change. The cause and clinical implications of the observed decrement in rIMT after ACS need further studies.
View article: Reactivity to low-flow as a potential determinant for brachial artery flow-mediated vasodilatation
Reactivity to low-flow as a potential determinant for brachial artery flow-mediated vasodilatation Open
Previous studies have reported a vasoconstrictor response in the radial artery during a cuff-induced low-flow condition, but a similar low-flow condition in the brachial artery results in nonuniform reactivity. This variable reactivity to …
View article: Hyperglycemia Induced by Glucokinase Deficiency Accelerates Atherosclerosis Development and Impairs Lesion Regression in Combined Heterozygous Glucokinase and the Apolipoprotein E-Knockout Mice
Hyperglycemia Induced by Glucokinase Deficiency Accelerates Atherosclerosis Development and Impairs Lesion Regression in Combined Heterozygous Glucokinase and the Apolipoprotein E-Knockout Mice Open
Aim . Models combining diabetes and atherosclerosis are important in evaluating the cardiovascular (CV) effects and safety of antidiabetes drugs in the development of treatments targeting CV complications. Our aim was to evaluate if crossi…
View article: P3.5 TYPE 2 DIABETES EXACERBATES CAROTID ARTERY ECHOGENICITY AND CENTRAL ARTERY STIFFNESS IN MIDDLE-AGED AND OLDER INDIVIDUALS
P3.5 TYPE 2 DIABETES EXACERBATES CAROTID ARTERY ECHOGENICITY AND CENTRAL ARTERY STIFFNESS IN MIDDLE-AGED AND OLDER INDIVIDUALS Open
Grey scale median of the common carotid artery intima-media complex (IM-GSM) characterizes the composition of the arterial wall and low IM-GSM reflects more generalized atherosclerotic vulnerability. However, it is unclear whether the pres…