Damir Janigro
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View article: The role of the blood–brain barrier during neurological disease and infection
The role of the blood–brain barrier during neurological disease and infection Open
A healthy brain is protected by the blood–brain barrier (BBB), which is formed by the endothelial cells that line brain capillaries. The BBB plays an extremely important role in supporting normal neuronal function by maintaining the homeos…
View article: Diagnostic biomarker kinetics: how brain-derived biomarkers distribute through the human body, and how this affects their diagnostic significance - the case of S100B
Diagnostic biomarker kinetics: how brain-derived biomarkers distribute through the human body, and how this affects their diagnostic significance - the case of S100B Open
Blood biomarkers of neurological diseases are often employed to rule out or confirm the presence of significant intracranial or cerebrovascular pathology or for the differential diagnosis of conditions with similar presentations (e.g., hem…
View article: Editorial: Biomarkers of Brain Damage – A Complex Challenge With Great Potential
Editorial: Biomarkers of Brain Damage – A Complex Challenge With Great Potential Open
EDITORIAL article Front. Neurol., 18 March 2021Sec. Neurotrauma Volume 12 - 2021 | https://doi.org/10.3389/fneur.2021.664445
View article: In vitro Models of the Blood–Brain Barrier: Tools in Translational Medicine
In vitro Models of the Blood–Brain Barrier: Tools in Translational Medicine Open
Medical progress has historically depended on scientific discoveries. Until recently, science was driven by technological advancements that, once translated to the clinic, fostered new treatments and interventions. More recently, technolog…
View article: How do we use in vitro models to understand epileptiform and ictal activity? A report of the <scp>TASK</scp>1‐<scp>WG</scp>4 group of the <scp>ILAE</scp>/<scp>AES</scp> Joint Translational Task Force
How do we use in vitro models to understand epileptiform and ictal activity? A report of the <span>TASK</span>1‐<span>WG</span>4 group of the <span>ILAE</span>/<span>AES</span> Joint Translational Task Force Open
Summary In vitro brain tissue preparations allow the convenient and affordable study of brain networks and have allowed us to garner molecular, cellular, and electrophysiologic insights into brain function with a detail not achievable in v…
View article: The role of brain barriers in fluid movement in the CNS: is there a ‘glymphatic’ system?
The role of brain barriers in fluid movement in the CNS: is there a ‘glymphatic’ system? Open
Brain fluids are rigidly regulated to provide stable environments for neuronal function, e.g., low K+, Ca2+, and protein to optimise signalling and minimise neurotoxicity. At the same time, neuronal and astroglial waste must be promptly re…
View article: Methodological standards for in vitro models of epilepsy and epileptic seizures. A <scp>TASK</scp>1‐<scp>WG</scp>4 report of the <scp>AES</scp>/<scp>ILAE</scp> Translational Task Force of the ILAE
Methodological standards for in vitro models of epilepsy and epileptic seizures. A <span>TASK</span>1‐<span>WG</span>4 report of the <span>AES</span>/<span>ILAE</span> Translational Task Force of the ILAE Open
Summary In vitro preparations are a powerful tool to explore the mechanisms and processes underlying epileptogenesis and ictogenesis. In this review, we critically review the numerous in vitro methodologies utilized in epilepsy research. W…
View article: Cerebral Waste Accumulation and Glymphatic Clearance as Mechanisms of Human Neurological Diseases
Cerebral Waste Accumulation and Glymphatic Clearance as Mechanisms of Human Neurological Diseases Open
The brain is a complex system that requires continual regulation of parenchymal pressure, osmolarity, and waste removal for optimal function; despite this, human brain lacks any obvious extension of lymphatic circulation for moderating flu…
View article: S100B and S100B autoantibody as biomarkers for early detection of brain metastases in lung cancer
S100B and S100B autoantibody as biomarkers for early detection of brain metastases in lung cancer Open
Serum S100B and S100B autoantibody levels may help to identify which lung cancer patients have brain metastases.
View article: <scp>WONOEP</scp> appraisal: Molecular and cellular biomarkers for epilepsy
<span>WONOEP</span> appraisal: Molecular and cellular biomarkers for epilepsy Open
Summary Peripheral biomarkers have myriad potential uses for treatment, prediction, prognostication, and pharmacovigilance in epilepsy. To date, no single peripheral biomarker has demonstrated proven effectiveness, although multiple candid…
View article: IgG from players with elevated anti-S100B levels recognize glial and neuronal epitopes.
IgG from players with elevated anti-S100B levels recognize glial and neuronal epitopes. Open
Serum samples obtained from selected players (highest and lowest auto-S100B antibody titers, see # and * in Figure 4) where used as “primary” antibody for recognition of brain epitopes. A control porcine brain was used (see text for detail…
View article: FPLC-Western Blot and Mass spectroscopy screening of auto-Ab candidates.
FPLC-Western Blot and Mass spectroscopy screening of auto-Ab candidates. Open
A) Control human brain protein content was fractioned by molecular weight using FPLC. Fractions between 170 and 50 kDa are shown on a polyacrilamide gel (15% SDS) to further separate proteins by molecular weight. This two-step technique al…
View article: Sertraline‐induced potentiation of the CYP3A4‐dependent neurotoxicity of carbamazepine: An in vitro study
Sertraline‐induced potentiation of the CYP3A4‐dependent neurotoxicity of carbamazepine: An in vitro study Open
Summary Objective Drug toxicity is a hurdle to drug development and to clinical translation of basic research. Antiepileptic drugs such as carbamazepine ( CBZ ) and selective serotonin reuptake inhibitors such as sertraline ( SRT ) are com…