Damjan Makuc
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View article: Efficient and Selective Biosynthesis of a Precursor-Directed FK506 Analogue: Paving the Way for Click Chemistry
Efficient and Selective Biosynthesis of a Precursor-Directed FK506 Analogue: Paving the Way for Click Chemistry Open
The medically important immunosuppressant FK506 is a structurally complex macrolactone biosynthesized by a combined polyketide synthase and a nonribosomal peptide synthetase enzyme complex. Its acyltransferase domain 4 (AT4) selects an unu…
View article: Azo-Bridged Dextran: A Photoresponsive Sustainable Material with Photo-Tunable Mechanical Properties
Azo-Bridged Dextran: A Photoresponsive Sustainable Material with Photo-Tunable Mechanical Properties Open
We report on the synthesis, characterization, and properties of dextran polymers, which are covalently bridged/cross-linked by azobenzene moieties. The reversible photoactivity of the azo moiety is retained in the polymers, and the kinetic…
View article: Unlocking innovation: Novel films synthesised and structurally analysed from poly (l-lactide-co-ethylene adipate) block copolymers blended with poly(lactic acid)
Unlocking innovation: Novel films synthesised and structurally analysed from poly (l-lactide-co-ethylene adipate) block copolymers blended with poly(lactic acid) Open
This study addresses the inherent shortcomings of poly (lactic acid) (PLA), a biodegradable polymer widely used in industries such as packaging and biomedical applications. The principal challenge of PLA resides in its low crystallinity, w…
View article: Hyaluronic acid conjugates of glycine peptides and L-tryptophan
Hyaluronic acid conjugates of glycine peptides and L-tryptophan Open
This work reports about the conjugation of glycine C-terminal ethyl and methyl ester peptides and L-tryptophan methyl ester with sodium hyaluronate in aqueous solutions using the peptide coupling agent DMTMM (or short DMT, 4-(4,6-dimethoxy…
View article: Unlocking Innovation: Novel Films Synthesized and Structurally Analysed from Poly (L-Lactide-Co-Ethylene Adipate) Block Copolymers Blended with Poly(Lactic Acid)
Unlocking Innovation: Novel Films Synthesized and Structurally Analysed from Poly (L-Lactide-Co-Ethylene Adipate) Block Copolymers Blended with Poly(Lactic Acid) Open
View article: Sustained Delivery of Cu(II)-Based DNA Intercalators by Nanometer-Sized Cyclodextrin-Based Porous Polymers
Sustained Delivery of Cu(II)-Based DNA Intercalators by Nanometer-Sized Cyclodextrin-Based Porous Polymers Open
DNA intercalators are small molecules that insert between adjacent DNA base pairs and thus disturb DNA replication and transcription, which can lead to cell death. Certain metal complexes are excellent DNA intercalators and have shown prom…
View article: CCDC 2180664: Experimental Crystal Structure Determination
CCDC 2180664: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2180665: Experimental Crystal Structure Determination
CCDC 2180665: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Cytotoxicity and Antibacterial Efficacy of Betaine- and Choline-Substituted Polymers
Cytotoxicity and Antibacterial Efficacy of Betaine- and Choline-Substituted Polymers Open
Cationic charge has been widely used to increase polymer adsorption and flocculation of dispersions or to provide antimicrobial activity. In this work, cationization of hydroxyethyl cellulose (HEC) and polyvinyl alcohol (PVA) was achieved …
View article: Efficiency of Neat and Quaternized-Cellulose Nanofibril Fillers in Chitosan Membranes for Direct Ethanol Fuel Cells
Efficiency of Neat and Quaternized-Cellulose Nanofibril Fillers in Chitosan Membranes for Direct Ethanol Fuel Cells Open
In this work, fully polysaccharide based membranes were presented as self-standing, solid polyelectrolytes for application in anion exchange membrane fuel cells (AEMFCs). For this purpose, cellulose nanofibrils (CNFs) were modified success…
View article: Nitroreductase-sensitive fluorescent covalent organic framework for tumor hypoxia imaging in cells
Nitroreductase-sensitive fluorescent covalent organic framework for tumor hypoxia imaging in cells Open
A fluorescent covalent organic framework (COF) for imaging hypoxic conditions in tumor cells.
View article: Children gut microbiota exhibits a different composition and metabolic profile after in vitro exposure to Clostridioides difficile and increases its sporulation
Children gut microbiota exhibits a different composition and metabolic profile after in vitro exposure to Clostridioides difficile and increases its sporulation Open
Clostridioides difficile (Clostridium difficile) infection (CDI) is one of the main public health concerns in adults, while children under 2 years of age are often colonized asymptomatically. In both adults and children, CDI is strongly as…
View article: Efficiency of neat and quaternized-cellulose nanofibril fillers in chitosan membranes for direct ethanol fuel cells
Efficiency of neat and quaternized-cellulose nanofibril fillers in chitosan membranes for direct ethanol fuel cells Open
Herein, we introduced the fully polysaccharide-based membranes as self-standing, solid polyelectrolytes for anion exchange membrane fuel cell (AEMFC) application. To this end, cellulose nanofibrils CNFs have been successfully modified by o…
View article: Glasdegib Dimaleate: Synthesis, Characterization and Comparison of Its Properties with Monomaleate Analogue
Glasdegib Dimaleate: Synthesis, Characterization and Comparison of Its Properties with Monomaleate Analogue Open
Glasdegib is a recently approved drug for the treatment of acute myeloid leukemia. It is formulated and marketed in monomaleate salt form. In our investigation, we were able to prepare a glasdegib dimaleate form, which could, in theory, ex…
View article: Organic acid cross-linked 3D printed cellulose nanocomposite bioscaffolds with controlled porosity, mechanical strength, and biocompatibility
Organic acid cross-linked 3D printed cellulose nanocomposite bioscaffolds with controlled porosity, mechanical strength, and biocompatibility Open
View article: Succinylation of Polyallylamine: Influence on Biological Efficacy and the Formation of Electrospun Fibers
Succinylation of Polyallylamine: Influence on Biological Efficacy and the Formation of Electrospun Fibers Open
Succinylation of proteins is a commonly encountered reaction in biology and introduces negatively charged carboxylates on previously basic primary amine groups of amino acid residues. In analogy, this work investigates the succinylation of…
View article: Influence of Charge and Heat on the Mechanical Properties of Scaffolds from Ionic Complexation of Chitosan and Carboxymethyl Cellulose
Influence of Charge and Heat on the Mechanical Properties of Scaffolds from Ionic Complexation of Chitosan and Carboxymethyl Cellulose Open
As one of the most abundant, multifunctional biological polymers, polysaccharides are considered promising materials to prepare tissue engineering scaffolds. When properly designed, wetted porous scaffolds can have biomechanics similar to …
View article: Water-based carbodiimide mediated synthesis of polysaccharide-amino acid conjugates: Deprotection, charge and structural analysis
Water-based carbodiimide mediated synthesis of polysaccharide-amino acid conjugates: Deprotection, charge and structural analysis Open
View article: Organic Acid Crosslinked 3D Printed Cellulose Nanocomposite Bioscaffolds With Controlled Porosity, Mechanical Strength and Biocompatibility
Organic Acid Crosslinked 3D Printed Cellulose Nanocomposite Bioscaffolds With Controlled Porosity, Mechanical Strength and Biocompatibility Open
View article: Off-line multidimensional high performance thin-layer chromatography for fractionation of Japanese knotweed rhizome bark extract and isolation of flavan-3-ols, proanthocyanidins and anthraquinones
Off-line multidimensional high performance thin-layer chromatography for fractionation of Japanese knotweed rhizome bark extract and isolation of flavan-3-ols, proanthocyanidins and anthraquinones Open
A methodology based on off-line multidimensional thin-layer chromatography was developed for isolation of several secondary metabolites from bark of Japanese knotweed (Fallopia japonica Houtt.) rhizomes. Successive fractionation steps usin…
View article: CCDC 1990630: Experimental Crystal Structure Determination
CCDC 1990630: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1990631: Experimental Crystal Structure Determination
CCDC 1990631: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Co-crystals, Salts or Mixtures of Both? The Case of Tenofovir Alafenamide Fumarates
Co-crystals, Salts or Mixtures of Both? The Case of Tenofovir Alafenamide Fumarates Open
Tenofovir alafenamide fumarate (TAF) is the newest prodrug of tenofovir that constitutes several drug products used for the treatment of HIV/AIDS. Although the solid-state properties of its predecessor tenofovir disoproxil fumarate have be…
View article: Determination of d-Cycloserine Impurities in Pharmaceutical Dosage Forms: Comparison of the International Pharmacopoeia HPLC–UV Method and the DOSY NMR Method
Determination of d-Cycloserine Impurities in Pharmaceutical Dosage Forms: Comparison of the International Pharmacopoeia HPLC–UV Method and the DOSY NMR Method Open
d-cycloserine is a broad-spectrum antibiotic that is currently being used as a secondary choice in the treatment of tuberculosis. In recent years, it has become more popular, due to its effect on the nervous system. In this current study, …
View article: Interference of oleamide with analytical and bioassay results
Interference of oleamide with analytical and bioassay results Open
View article: Generic Method for Designing Self-Standing and Dual Porous 3D Bioscaffolds from Cellulosic Nanomaterials for Tissue Engineering Applications
Generic Method for Designing Self-Standing and Dual Porous 3D Bioscaffolds from Cellulosic Nanomaterials for Tissue Engineering Applications Open
Three-dimensional scaffolds (3D) with controlled shape, dual porosity and long-term mechanical and dimensional stability in biofluids are of interest as biotemplates in tissue engineering. Herein, self-standing and lightweight cellulose-ba…
View article: Probing the Effects of Pyrimidine Functional Group Switches on Acyclic Fleximer Analogues for Antiviral Activity
Probing the Effects of Pyrimidine Functional Group Switches on Acyclic Fleximer Analogues for Antiviral Activity Open
Due to their ability to inhibit viral DNA or RNA replication, nucleoside analogues have been used for decades as potent antiviral therapeutics. However, one of the major limitations of nucleoside analogues is the development of antiviral r…
View article: Intestinal Metagenomes and Metabolomes in Healthy Young Males: Inactivity and Hypoxia Generated Negative Physiological Symptoms Precede Microbial Dysbiosis
Intestinal Metagenomes and Metabolomes in Healthy Young Males: Inactivity and Hypoxia Generated Negative Physiological Symptoms Precede Microbial Dysbiosis Open
We explored the metagenomic, metabolomic and trace metal makeup of intestinal microbiota and environment in healthy male participants during the run-in (5 day) and the following three 21-day interventions: normoxic bedrest (NBR), hypoxic b…
View article: Small molecule purine and pseudopurine derivatives: synthesis, cytostatic evaluations and investigation of growth inhibitory effect in non-small cell lung cancer A549
Small molecule purine and pseudopurine derivatives: synthesis, cytostatic evaluations and investigation of growth inhibitory effect in non-small cell lung cancer A549 Open
Novel halogenated purines and pseudopurines with diverse aryl-substituted 1,2,3-triazoles were prepared. While p-(trifluoromethyl)-substituted 1,2,3-triazole in N-9 alkylated purine and 3-deazapurine was critical for strong albeit u…
View article: Water-Soluble Colorimetric Amino[<i>bis</i>(ethanesulfonate)] Azobenzene pH Indicators: A UV–Vis Absorption, DFT, and <sup>1</sup>H–<sup>15</sup>N NMR Spectroscopy Study
Water-Soluble Colorimetric Amino[<i>bis</i>(ethanesulfonate)] Azobenzene pH Indicators: A UV–Vis Absorption, DFT, and <sup>1</sup>H–<sup>15</sup>N NMR Spectroscopy Study Open
Water-soluble azobenzene derivatives containing amino[bis(ethanesulfonate)] groups are demonstrated as colorful pH indicators in water and on filter paper. Vibrant color changes were observed from yellow/orange to pink between pH 1 …