Jiong Wu
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View article: Current Trends in Revision Surgery After Breast Reconstruction in China: Insights from a Nationwide Cross-Sectional Survey
Current Trends in Revision Surgery After Breast Reconstruction in China: Insights from a Nationwide Cross-Sectional Survey Open
Introduction Revision surgery is an integral component of post-mastectomy breast reconstruction, aimed at enhancing breast aesthetics and improving patient satisfaction. While developed countries have established high rates of revision sur…
View article: Current Practices and Evolving Trends in Implant-based Breast Reconstruction in China: A Nationwide Cross-sectional Survey
Current Practices and Evolving Trends in Implant-based Breast Reconstruction in China: A Nationwide Cross-sectional Survey Open
Background: Implant-based breast reconstruction (IBBR) is widely used globally and in China, but regional disparities and concerns about complications persist. This nationwide survey evaluates current IBBR practices and trends. Methods: A …
View article: Efficacy and Safety of Neoadjuvant TQB2102 in Locally Advanced or Early Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer: A Randomized, Open-Label, Multicenter, Phase II Trial
Efficacy and Safety of Neoadjuvant TQB2102 in Locally Advanced or Early Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer: A Randomized, Open-Label, Multicenter, Phase II Trial Open
PURPOSE To evaluate the efficacy and safety of the bispecific human epidermal growth factor receptor 2 (HER2)–directed antibody-drug conjugate (ADC) TQB2102 in the neoadjuvant treatment of HER2-positive breast cancer. PATIENTS AND METHODS …
View article: Current landscape and challenges in autologous breast reconstruction across China: A nationwide questionnaire-based survey of 198 hospitals
Current landscape and challenges in autologous breast reconstruction across China: A nationwide questionnaire-based survey of 198 hospitals Open
ABR is steadily increasing in China, accompanied by a gradual shift towards perforator-based techniques such as deep inferior epigastric artery perforator flaps. However, its provision remains concentrated in tertiary centres with strong s…
View article: Reconstruction strategies for extensive bone defects following resection of primary malignant tumors in the distal radius
Reconstruction strategies for extensive bone defects following resection of primary malignant tumors in the distal radius Open
Background This study aimed to evaluate surgical resection techniques for primary malignant tumors of the distal radius and to examine the reconstruction strategies employed for resulting large bone defects. Methods A retrospective analysi…
View article: Neoadjuvant trastuzumab deruxtecan alone or followed by paclitaxel, trastuzumab, and pertuzumab for high-risk HER2-positive early breast cancer (DESTINY-Breast11): a randomised, open-label, multicentre, phase III trial
Neoadjuvant trastuzumab deruxtecan alone or followed by paclitaxel, trastuzumab, and pertuzumab for high-risk HER2-positive early breast cancer (DESTINY-Breast11): a randomised, open-label, multicentre, phase III trial Open
Neoadjuvant T-DXd-THP demonstrated statistically significant and clinically meaningful pCR benefit and improved safety versus ddAC-THP.
View article: Associations of socioeconomic and occupational characteristics with occupational health literacy among essential service workers in Guangdong, China
Associations of socioeconomic and occupational characteristics with occupational health literacy among essential service workers in Guangdong, China Open
Socioeconomic and occupational characteristics significantly influence OHL among essential service workers, with patterns varying across industries. These findings suggest the need for targeted interventions that consider educational backg…
View article: XBP1s Mediates Cross‐resistance to Combination Treatment of CDK4/6 Inhibitors plus Endocrine Therapy in Breast Cancer
XBP1s Mediates Cross‐resistance to Combination Treatment of CDK4/6 Inhibitors plus Endocrine Therapy in Breast Cancer Open
CDK4/6 inhibitors combined with endocrine therapy is the standard treatment for patients with hormone receptor‐positive (HR+)/human epidermal growth factor receptor 2‐negative (HER2−) metastatic breast cancer (MBC). However, the inevitable…
View article: Enterprise characteristics and occupational health literacy among essential service workers in Guangdong Province, China: a cross-sectional study
Enterprise characteristics and occupational health literacy among essential service workers in Guangdong Province, China: a cross-sectional study Open
Background Essential service workers are exposed to significant occupational health risks. Low occupational health literacy (OHL) has been linked to increased risks of occupational injuries and work-related illnesses. However, limited evid…
View article: Evolving Trends in Postmastectomy Breast Reconstruction With Autologous Tissues: A Large‐Scale, 24‐Year Retrospective Study in China
Evolving Trends in Postmastectomy Breast Reconstruction With Autologous Tissues: A Large‐Scale, 24‐Year Retrospective Study in China Open
Background Autologous breast reconstruction (ABR) significantly improves quality of life following mastectomy. However, ABR has traditionally been underutilized compared to implant‐based breast reconstruction (IBBR), partly due to its tech…
View article: Chinese expert consensus on clinical diagnosis and treatment of breast cancer targeting HER2
Chinese expert consensus on clinical diagnosis and treatment of breast cancer targeting HER2 Open
The overarching goal of this consensus is to deliver individualized treatment strategies that not only prolong survival but also enhance quality of life, ensuring HER2-positive breast cancer patients receive the most advanced, patient-cent…
View article: Dihydrotanshinone I Induces Autophagic Cell Death in Ovarian Cancer by Disrupting the SORT1-Mediated Autophagy–Lysosome Pathway
Dihydrotanshinone I Induces Autophagic Cell Death in Ovarian Cancer by Disrupting the SORT1-Mediated Autophagy–Lysosome Pathway Open
Ovarian cancer (OC), a common malignancy of the female reproductive system, has the highest mortality rate among gynecological cancers. A distinguishing feature of OC cells (OCCs) is their reduced autophagic flux compared with normal cells…
View article: Safety and quality of life of CDK4/6 inhibitors therapy for hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer: a multicenter cross-sectional survey in China
Safety and quality of life of CDK4/6 inhibitors therapy for hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer: a multicenter cross-sectional survey in China Open
The safety profile of different CDK4/6i varies and has different impacts on patients' quality of life, which needs more attention in clinical practice.
View article: Feasibility and Outcomes of Vessel-Sparing Surgery for Soft Tissue Sarcoma of the Thigh Adjacent to Femoral Vessels
Feasibility and Outcomes of Vessel-Sparing Surgery for Soft Tissue Sarcoma of the Thigh Adjacent to Femoral Vessels Open
For soft tissue sarcoma of the thigh located adjacent to femoral vessels, vessel-sparing surgery involving vascular sheath removal demonstrates favorable outcomes. Tumor size greater than 10 cm and high pathological grade were significant …
View article: PPARG Activation of Fatty Acid Metabolism Drives Resistance to Anti-HER2 Therapies in HER2-Positive Breast Cancer
PPARG Activation of Fatty Acid Metabolism Drives Resistance to Anti-HER2 Therapies in HER2-Positive Breast Cancer Open
HER2-positive breast cancer, which accounts for approximately 15-20% of all breast cancers, is characterized by its aggressive recurrence, metastasis and reduced survival. Despite advances in anti-HER2 therapies, many patients continue to …
View article: Hypofractionated partial breast irradiation after breast-conserving surgery for patients with early stage breast cancer in China Mainland: a single-arm prospective trial
Hypofractionated partial breast irradiation after breast-conserving surgery for patients with early stage breast cancer in China Mainland: a single-arm prospective trial Open
To report the results of a single-arm, prospective partial breast irradiation (PBI) trial from China mainland using a dose of 40.05 Gy in 15 fractions delivered with intensity-modulated radiation therapy (IMRT) technique for patients with …
View article: Comprehensive Pan-Cancer Analysis of RAC1 Decoding the Impact on Cancer Prognosis and B cell immune Regulation
Comprehensive Pan-Cancer Analysis of RAC1 Decoding the Impact on Cancer Prognosis and B cell immune Regulation Open
RAC1, a member of the Rho family GTPases, has been implicated in various cancers, yet its pan-cancer landscape and role in the tumor immune microenvironment remain underexplored. This study presents a comprehensive analysis of RAC1 across …
View article: Protocol for a multicentre, prospective, open-label, randomised controlled trial to compare PROs and safety outcomes between preoperative and postmastectomy radiotherapy in locally advanced breast cancer patients with immediate reconstruction via a deep inferior epigastric perforator flap (CAPPELLA) in China
Protocol for a multicentre, prospective, open-label, randomised controlled trial to compare PROs and safety outcomes between preoperative and postmastectomy radiotherapy in locally advanced breast cancer patients with immediate reconstruction via a deep inferior epigastric perforator flap (CAPPELLA) in China Open
Introduction Despite its therapeutic advantages, postmastectomy radiotherapy (PMRT) increases the risk of complications and often leads to poor cosmesis in women undergoing breast reconstruction. Preoperative radiotherapy followed by skin-…
View article: Post-mastectomy hypofractionated versus conventionally fractionated radiation therapy for patients receiving immediate breast reconstruction: Subgroup analysis of a phase III randomized trial
Post-mastectomy hypofractionated versus conventionally fractionated radiation therapy for patients receiving immediate breast reconstruction: Subgroup analysis of a phase III randomized trial Open
•The incidence of complications is higher for patients with TE irradiated, then for those with PI, and the lowest for those with AT.•The use of hypofractionation in patients with any type of IBR does not seem to increase complications as c…
View article: Intensive chemotherapy versus standard chemotherapy among patients with high risk, operable, triple negative breast cancer based on integrated mRNA-lncRNA signature (BCTOP-T-A01): randomised, multicentre, phase 3 trial
Intensive chemotherapy versus standard chemotherapy among patients with high risk, operable, triple negative breast cancer based on integrated mRNA-lncRNA signature (BCTOP-T-A01): randomised, multicentre, phase 3 trial Open
Objective To evaluate the feasibility of using a multigene signature to tailor individualised adjuvant therapy for patients with operable triple negative breast cancer. Design Randomised, multicentre, open label, phase 3 trial. Setting 7 c…
View article: Efficacy and Safety of Roxadustat for Anemia in Patients Receiving Chemotherapy for Nonmyeloid Malignancies: A Randomized, Open-Label, Active-Controlled Phase III Study
Efficacy and Safety of Roxadustat for Anemia in Patients Receiving Chemotherapy for Nonmyeloid Malignancies: A Randomized, Open-Label, Active-Controlled Phase III Study Open
PURPOSE We evaluated the efficacy and safety of roxadustat, a first-in-class hypoxia-inducible factor prolyl hydroxylase inhibitor, for chemotherapy-induced anemia (CIA) in patients with nonmyeloid malignancies receiving multicycle treatme…
View article: A Study on Short-Term Traffic Flow Prediction Based on Random Forest Regression
A Study on Short-Term Traffic Flow Prediction Based on Random Forest Regression Open
Accurate and rapid prediction of short-term traffic flow is of great significance for improving the efficiency of traffic management as well as alleviating the pressure of urban traffic. In this paper, the traffic flow data are first analy…
View article: ERAS-Based Anesthetic Management of Patients Undergoing Abdominal-Based Free Flap Breast Reconstruction: A Narrative Review
ERAS-Based Anesthetic Management of Patients Undergoing Abdominal-Based Free Flap Breast Reconstruction: A Narrative Review Open
Microsurgical breast reconstruction after mastectomy is emerging as the standard of care for patients with breast cancer. The enhanced recovery after surgery (ERAS) pathway in abdominal-based free flap breast reconstruction is in its early…
View article: Comparing long-term prognosis following different surgical methods in patients with early stage breast cancer and obesity: a retrospective cohort study in China
Comparing long-term prognosis following different surgical methods in patients with early stage breast cancer and obesity: a retrospective cohort study in China Open
Objective Breast-conserving therapy (BCT) includes breast-conserving surgery (BCS) combined with radiation therapy (RT). RT plays a crucial role in improving the prognosis of patients who undergo BCS. However, obesity is a potential risk f…