Dan Dion
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View article: Investigating the Role of SNAI1 and ZEB1 Expression in Prostate Cancer Progression and Immune Modulation of the Tumor Microenvironment
Investigating the Role of SNAI1 and ZEB1 Expression in Prostate Cancer Progression and Immune Modulation of the Tumor Microenvironment Open
Prostate cancer (PCa) is an immunologically cold tumor and the molecular processes that underlie this behavior are poorly understood. In this study, we investigated a primary cohort of intermediate-risk PCa (n = 51) using two NanoString pr…
View article: Multimodal Biomarkers That Predict the Presence of Gleason Pattern 4: Potential Impact for Active Surveillance
Multimodal Biomarkers That Predict the Presence of Gleason Pattern 4: Potential Impact for Active Surveillance Open
Two grade group classifiers with superior accuracy were developed by incorporating RNA and DNA features and validated in an independent cohort. Upon further validation in biopsy samples, classifiers with these performance characteristics c…
View article: A three‐gene DNA methylation biomarker accurately classifies early stage prostate cancer
A three‐gene DNA methylation biomarker accurately classifies early stage prostate cancer Open
Background We identify and validate accurate diagnostic biomarkers for prostate cancer through a systematic evaluation of DNA methylation alterations. Materials and methods We assembled three early prostate cancer cohorts (total patients =…
View article: P065 Luminal A vs luminal B: impact of different St. Gallen Ki67 and PgR cut points in the TEAM study
P065 Luminal A vs luminal B: impact of different St. Gallen Ki67 and PgR cut points in the TEAM study Open
Goals: Metaplastic carcinoma is distinct albeit, rare and aggressive formof invasive breast cancer. Histologically, these tumors exemplify enrichment of tumor initiating markers such as CD44 and ALDH1 along with low expression of CD24. Our…