Dan E. Berkowitz
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Vasorin at the crossroads: charting new paths in preeclampsia research Open
Preeclampsia (PE) remains a leading cause of maternal and fetal morbidity and mortality worldwide, yet the precise molecular mechanisms driving its pathology are not fully understood. Recent research has established extracellular vesicles …
Decreased Extracellular Vesicle Vasorin in Severe Preeclampsia Plasma Mediates Endothelial Dysfunction Open
Background Preeclampsia is a serious pregnancy complication affecting 5% to 8% of pregnancies globally. preeclampsia is a leading cause of maternal and neonatal morbidity and death. Despite its prevalence, the underlying mechanisms of pree…
Placental extracellular vesicles from women with severe preeclampsia alter calcium homeostasis in cardiomyocytes: an ex vivo study Open
This study unveils a novel link between the placenta and PE-linked heart dysfunction. We isolated and characterized placental EVs from pregnancies with sPE and normotensive controls. These plasma sPE-EVs, and sPE-Plex EVs disrupt calcium s…
LOXL2 inhibition ameliorates pulmonary artery remodeling in pulmonary hypertension Open
Pulmonary arterial stiffening contributes to the progression of PAH and the deterioration of right heart function. This study shows that LOXL2 is upregulated in rat models of PH. LOXL2 inhibition halts pulmonary vascular remodeling and imp…
Grant drafting support with guided generative AI software Open
Grant writing is a time-consuming and labor-intensive process that is the essential mechanism by which most academic researchers fund their scientific investigations. To support this effort, we present a software application with correspon…
Decreased Extracellular Vesicle Vasorin in Severe Preeclampsia Plasma Mediates Endothelial Dysfunction Open
Background Preeclampsia (PE) is a serious pregnancy complication affecting 5-8% of pregnancies globally. It is a leading cause of maternal and neonatal morbidity and mortality. Despite its prevalence, the underlying mechanisms of PE remain…
Strengths-weaknesses-opportunities-threats analysis of artificial intelligence in anesthesiology and perioperative medicine Open
The use of artificial intelligence (AI) and machine learning (ML) in anesthesiology and perioperative medicine is quickly becoming a mainstay of clinical practice. Anesthesiology is a data-rich medical specialty that integrates multitudes …
LOXL2 inhibition ameliorates pulmonary artery remodeling in pulmonary hypertension Open
Background Conduit pulmonary arterial stiffening and the resultant increase in pulmonary vascular impedance has emerged as an important underlying driver of pulmonary arterial hypertension (PAH). Given that matrix deposition is central to …
Adenosine A <sub>2A</sub> Receptor Regulates microRNA‐181b Expression in Aorta: Therapeutic Implications for Large‐Artery Stiffness Open
Background The identification of large‐artery stiffness as a major, independent risk factor for cardiovascular disease–associated morbidity and death has focused attention on identifying therapeutic strategies to combat this disorder. Gene…
Artificial Intelligence in Perioperative Medicine: A Proposed Common Language With Applications to FDA-Approved Devices Open
As implementation of artificial intelligence grows more prevalent in perioperative medicine, a clinician's ability to distinguish differentiating aspects of these algorithms is critical. There are currently numerous marketing and technical…
Light-Mediated Inhibition of Colonic Smooth Muscle Constriction and Colonic Motility via Opsin 3 Open
Opsin photoreceptors outside of the central nervous system have been shown to mediate smooth muscle photorelaxation in several organs. We hypothesized that opsin receptor activation in the colon would have a similar effect and influence co…
Deciphering the Role of microRNAs in Large-Artery Stiffness Associated With Aging: Focus on miR-181b Open
Large artery stiffness (LAS) is a major, independent risk factor underlying cardiovascular disease that increases with aging. The emergence of microRNA signaling as a key regulator of vascular structure and function has stimulated interest…
Degradation of Premature-miR-181b by the Translin/Trax RNase Increases Vascular Smooth Muscle Cell Stiffness Open
Large artery stiffness is a major risk factor underlying cardiovascular disease. However, the molecular mechanisms driving this pathological process are poorly understood. Previous studies indicate that the age-associated decline of miR-18…
Identification of novel bladder sensory GPCRs Open
Sensory GPCRs such as olfactory receptors (ORs), taste receptors (TRs), and opsins (OPNs) are now known to play important physiological roles beyond their traditional sensory organs. Here, we systematically investigate the expression of se…
The bio-sonographic index. A novel modality for early detection of acute kidney injury after complex vascular surgery. A protocol for an exploratory prospective study Open
Objective Acute kidney injury (AKI) is a common complication of complex aortic surgery with high mortality, morbidity and health care expense. The current definition of AKI does not allow for structural characterization of the kidneys and …
Aging and chronic high-fat feeding negatively affect kidney size, function, and gene expression in CTRP1-deficient mice Open
C1q/TNF-related protein 1 (CTRP1) is an endocrine factor with metabolic, cardiovascular, and renal functions. We previously showed that aged Ctrp1-knockout (KO) mice fed a control low-fat diet develop renal hypertrophy and dysfunction. Sin…
Opsin 3–G <sub>αs</sub> Promotes Airway Smooth Muscle Relaxation Modulated by G Protein Receptor Kinase 2 Open
Recently, we characterized blue light-mediated relaxation (photorelaxation) of airway smooth muscle (ASM) and implicated the involvement of opsin 3 (OPN3), an atypical opsin. In the present study, we characterized the cellular signaling me…
Tentonin 3 as a baroreceptor mechanosensor: not a stretch Open
Mechanical stretch of baroreceptors in the wall of the aortic arch and carotid sinus initiates autonomic reflexes to change heart rate and blood pressure for cardiovascular homeostasis. In this issue of the JCI, Lu et al. show that tentoni…
Role of senescence marker p16INK4a measured in peripheral blood T-lymphocytes in predicting length of hospital stay after coronary artery bypass surgery in older adults Open
Adults older than 65 years undergo more than 120,000 coronary artery bypass (CAB) procedures each year in the United States. Chronological age alone, though commonly used in prediction models of outcomes after CAB, does not alone reflect v…
Biomimetic human small muscular pulmonary arteries Open
Biofabricated mass-producible arteries containing layered and aligned cells and matrix exhibit enhanced cellular function.
Assessing Renal Microvascular Reactivity by Laser Speckle-Contrast Imaging in Angiotensin-II-Treated Mice Open
We developed an innovative technique to study renal microcirculation in mice. Ang-II-treated mice showed significantly higher basal blood flow than controls, while PORH was significantly higher in controls than in Ang-II mice.
Novel Expression of GABAA Receptors on Resistance Arteries That Modulate Myogenic Tone Open
The clinical administration of GABAergic medications leads to hypotension which has classically been attributed to the modulation of neuronal activity in the central and peripheral nervous systems. However, certain types of peripheral smoo…
Late‐onset renal hypertrophy and dysfunction in mice lacking CTRP1 Open
Local and systemic factors that influence renal structure and function in aging are not well understood. The secretory protein C1q/TNF‐related protein 1 (CTRP1) regulates systemic metabolism and cardiovascular function. We provide evidence…
Deletion of the microRNA-degrading nuclease, translin/trax, prevents pathogenic vascular stiffness Open
Vascular stiffness plays a key role in the pathogenesis of hypertension. Recent studies indicate that the age-associated reduction in miR-181b levels in vascular smooth muscle cells (VSMCs) contributes to increased vascular stiffness. As t…
Editorial: Regulation of Vascular Function by Circulating Blood Open
EDITORIAL article Front. Physiol., 16 May 2019Sec. Vascular Physiology Volume 10 - 2019 | https://doi.org/10.3389/fphys.2019.00492