Dan Eniu
YOU?
Author Swipe
View article: The Relationship Between Erectile Dysfunction and Dyadic Adjustment, Couple Relationship Quality, and Intimacy: A Cross-Sectional Study
The Relationship Between Erectile Dysfunction and Dyadic Adjustment, Couple Relationship Quality, and Intimacy: A Cross-Sectional Study Open
Background and Objectives: This study aimed to evaluate the association between relationship dynamics as measured by dyadic adjustment and factors such as erectile function and lower urinary tract symptoms, adjusting for relevant clinical …
View article: Moderate-Low Risk Breast Cancer Gene Expression in a Romanian Population
Moderate-Low Risk Breast Cancer Gene Expression in a Romanian Population Open
Multigene panel testing for hereditary breast and ovarian cancer is becoming a standard in medical care. Recent studies highlight the importance of pathogenic variants in genes with moderate or low penetrance. 255 consecutive breast cancer…
View article: Comparative Effects of Tadalafil Cream Versus Oral Tadalafil on Males with Erectile Disfunction Regarding Relationship Dynamics: A Secondary Analysis of Dyadic Adjustment Outcomes in a Randomized Crossover Trial
Comparative Effects of Tadalafil Cream Versus Oral Tadalafil on Males with Erectile Disfunction Regarding Relationship Dynamics: A Secondary Analysis of Dyadic Adjustment Outcomes in a Randomized Crossover Trial Open
Background/Objectives: Relationship quality is closely tied to sexual health. This study compared the effects of tadalafil cream and oral tadalafil on Dyadic Adjustment Scale (DAS) subscales and assessed the influence of age on treatment o…
View article: The Intra-Meatal Application of Tadalafil Cream Versus Oral Administration Efficacy and Safety: Results from a Randomized, Two-Administration Route, Cross-Over Clinical Trial
The Intra-Meatal Application of Tadalafil Cream Versus Oral Administration Efficacy and Safety: Results from a Randomized, Two-Administration Route, Cross-Over Clinical Trial Open
Background: Tadalafil cream, a topically administered phosphodiesterase-5 inhibitor (PDE5), presents a potential alternative to oral PDE5 inhibitors like tadalafil for the treatment of erectile dysfunction (ED). This study evaluates the no…
View article: Whole‐body non‐forensic fetal virtopsy using postmortem magnetic resonance imaging at 7 Tesla <i>vs</i> classical autopsy
Whole‐body non‐forensic fetal virtopsy using postmortem magnetic resonance imaging at 7 Tesla <i>vs</i> classical autopsy Open
Objective To determine the diagnostic accuracy of virtual autopsy using whole‐body postmortem ultra‐high field magnetic resonance imaging (MRI) at 7 Tesla (T), using a short T2‐weighted imaging (T2‐WI) protocol, compared with classical aut…
View article: Diagnosis of Relapse of Colorectal Adenocarcinoma through CEA Fluctuation
Diagnosis of Relapse of Colorectal Adenocarcinoma through CEA Fluctuation Open
Carcinoembryonic antigen(CEA) is a routine marker employed for follow-up of colorectal tumors. We aimed to determine whether a CEA increase within the normal range can be linked to a risk of recurrence. From the period of 2006–2013 we sele…
View article: Unselective Measurement of Tumor-to-Stroma Proportion in Colon Cancer at the Invasion Front—An Elusive Prognostic Factor: Original Patient Data and Review of the Literature
Unselective Measurement of Tumor-to-Stroma Proportion in Colon Cancer at the Invasion Front—An Elusive Prognostic Factor: Original Patient Data and Review of the Literature Open
The tumor-to-stroma ratio is a highly debated prognostic factor in the management of several solid tumors and there is no universal agreement on its practicality. In our study, we proposed confirming or dismissing the hypothesis that a sim…
View article: Unselective Measurement of Tumor‐to‐Stroma Proportion in Colon Cancer at the Invasion Front– an Elusive Prognostic Factor. Original Patient Data and Review of the Literature
Unselective Measurement of Tumor‐to‐Stroma Proportion in Colon Cancer at the Invasion Front– an Elusive Prognostic Factor. Original Patient Data and Review of the Literature Open
Tumor to stroma ratio is a highly debated prognostic factor in the management of several solid tumors and there is no universal agreement on its practicality. In our study we proposed to confirm or dismiss the hypothesis that a simple meas…
View article: Whole-Tumor ADC Texture Analysis Is Able to Predict Breast Cancer Receptor Status
Whole-Tumor ADC Texture Analysis Is Able to Predict Breast Cancer Receptor Status Open
There are different breast cancer molecular subtypes with differences in incidence, treatment response and outcome. They are roughly divided into estrogen and progesterone receptor (ER and PR) negative and positive cancers. In this retrosp…
View article: Structure–Activity Relationship Studies Based on Quinazoline Derivatives as EGFR Kinase Inhibitors (2017–Present)
Structure–Activity Relationship Studies Based on Quinazoline Derivatives as EGFR Kinase Inhibitors (2017–Present) Open
The epidermal growth factor receptor (EGFR) plays a critical role in the tumorigenesis of various forms of cancer. Targeting the mutant forms of EGFR has been identified as an attractive therapeutic approach and led to the approval of thre…
View article: Spectrum of High-Risk Mutations among Breast Cancer Patients Referred for Multigene Panel Testing in a Romanian Population
Spectrum of High-Risk Mutations among Breast Cancer Patients Referred for Multigene Panel Testing in a Romanian Population Open
(1) Background: Multigene panel testing for Hereditary Breast and Ovarian Cancer (HBOC) using next generation sequencing (NGS) is becoming a standard in medical care. There are insufficient genetic studies reported on breast cancer (BC) pa…
View article: Copy Number Variations (CNVs) Account for 10.8% of Pathogenic Variants in Patients Referred for Hereditary Cancer Testing
Copy Number Variations (CNVs) Account for 10.8% of Pathogenic Variants in Patients Referred for Hereditary Cancer Testing Open
In silico CNV detection tools provide a viable and cost-effective method to identify CNVs from NGS experiments. CNVs constitute a substantial percentage of P/LP variants, since they represent up to one of every ten P/LP findings identified…
View article: Multiparametric MRI Features of Breast Cancer Molecular Subtypes
Multiparametric MRI Features of Breast Cancer Molecular Subtypes Open
Background and Objectives: Breast cancer (BC) molecular subtypes have unique incidence, survival and response to therapy. There are five BC subtypes described by immunohistochemistry: luminal A, luminal B HER2 positive and HER2 negative, t…
View article: Are Mutation Carrier Patients Different from Non-Carrier Patients? Genetic, Pathology, and US Features of Patients with Breast Cancer
Are Mutation Carrier Patients Different from Non-Carrier Patients? Genetic, Pathology, and US Features of Patients with Breast Cancer Open
The purpose of this study is to evaluate the relationship between the pathogenic/likely pathogenic mutations, US features, and histopathologic findings of breast cancer in mutation carriers compared to non-carrier patients. Methods: In thi…
View article: Fluctuation of Serum CEA in the Conventional Normal Range and The Risk of Relapse Following Curative Intent Treatment of Colorectal Cancer
Fluctuation of Serum CEA in the Conventional Normal Range and The Risk of Relapse Following Curative Intent Treatment of Colorectal Cancer Open
Carcinoembriogenic antigen (CEA) is a routine marker for follow-up of colo-rectal cancers. We aimed to determine whether a CEA increase within the normal range can be linked to a recurrence risk. We included 78 consecutive patients with co…
View article: Revisiting the Implications of Positive Germline Testing Results Using Multi-gene Panels in Breast Cancer Patients
Revisiting the Implications of Positive Germline Testing Results Using Multi-gene Panels in Breast Cancer Patients Open
Germline findings in 92% of individuals are linked to evidence-based treatment information and risk estimates for predisposition to breast and/or other cancer types. The use of germline findings for treatment decision making expands the in…
View article: The Role of US in Depicting Axillary Metastasis in High-Risk Breast Cancer Patients
The Role of US in Depicting Axillary Metastasis in High-Risk Breast Cancer Patients Open
Purpose: The aim of this study is to evaluate the role of US in depicting axillary nodal disease in high-risk patients with and without pathogenic mutations. Methods: The retrospective study included consecutive high-risk breast cancer (BC…
View article: SBRT as Salvage Re-Irradiation for Isolated In-Field Regional Relapse After Bilateral Breast Cancer – a Case Report
SBRT as Salvage Re-Irradiation for Isolated In-Field Regional Relapse After Bilateral Breast Cancer – a Case Report Open
"Stereotactic body radiation therapy (SBRT) is a type of radiotherapy which uses a high radiation dose delivered in a single or a few fractions and is employed with local curative intent for early-stage cancer, relapsed cancer or in the ol…
View article: T4 retroperitoneal liposarcoma. Challenges of big size sarcomas surgical treatment
T4 retroperitoneal liposarcoma. Challenges of big size sarcomas surgical treatment Open
Our article presents some of the challenges of the surgical treatment of T4 (>15 cm) retroperitoneal liposarcomas (up to 65∕56∕30 cm, 25.5 kg) series of cases treated by the Department of Surgical Oncology, Prof. Dr. Ion Chiricuţă Oncology…
View article: 1081 Vulvar cancer treatment between 2010 and 2019: the experience of a single Romanian cancer center
1081 Vulvar cancer treatment between 2010 and 2019: the experience of a single Romanian cancer center Open
Introduction/Background* The purpose of this study was to evaluate 5-year overall survival (OS), disease free survival (DFS) and local control (LC) for patients diagnosed with primary vulvar cancer and treated at Institute of Oncology "Pro…
View article: MMTV Prevalence in Breast Cancer Samples in Romania - Do Major Geographical Differences Exist in The World Population?
MMTV Prevalence in Breast Cancer Samples in Romania - Do Major Geographical Differences Exist in The World Population? Open
Background Breast cancer, although the most frequently diagnosed malignant tumor in humans, has a less clear etiology compared to other frequent cancer types. Mouse-mammary tumor virus (MMTV) is involved in breast cancer in mice and dogs a…
View article: MMTV Prevalence in Breast Cancer Samples in Romania- Do Major Geographical Differences Exist in the World Population?
MMTV Prevalence in Breast Cancer Samples in Romania- Do Major Geographical Differences Exist in the World Population? Open
(1) Background: Mouse-mammary tumor virus (MMTV) might play a role in the etiology of some breast cancers in humans. The purpose of our study was to identify MMTV DNA sequences in breast tissue samples from breast cancer patients operated …
View article: MMTV Prevalence in Breast Cancer Samples in Romania- Do Major Geographical Differences Exist in the World Population?
MMTV Prevalence in Breast Cancer Samples in Romania- Do Major Geographical Differences Exist in the World Population? Open
Breast cancer, although the most frequently diagnosed malignant tumour in humans, has a less clear aetiology compared to other frequent cancer types. Mouse-mammary tumour virus (MMTV) is involved in breast cancer in mice and dogs and might…
View article: Endoscopic Ultrasound Elastography in the Assessment of Rectal Tumors: How Well Does It Work in Clinical Practice?
Endoscopic Ultrasound Elastography in the Assessment of Rectal Tumors: How Well Does It Work in Clinical Practice? Open
Endorectal ultrasound applications in the evaluation of rectal tumors could be a useful tool in achieving proper staging of rectal cancer. The purpose of this study was to compare the efficacy of rectal tumor staging by flexible endoscopic…
View article: Lipidomic Signatures for Colorectal Cancer Diagnosis and Progression Using UPLC-QTOF-ESI+MS
Lipidomic Signatures for Colorectal Cancer Diagnosis and Progression Using UPLC-QTOF-ESI+MS Open
Metabolomics coupled with bioinformatics may identify relevant biomolecules such as putative biomarkers of specific metabolic pathways related to colorectal diagnosis, classification and prognosis. This study performed an integrated metabo…
View article: Clinical Utility of Functional RNA Analysis for the Reclassification of Splicing Gene Variants in Hereditary Cancer
Clinical Utility of Functional RNA Analysis for the Reclassification of Splicing Gene Variants in Hereditary Cancer Open
The RNA analysis assisted in the reclassification of 20% of splicing variants from VUS to pathogenic. RNA analysis is essential in the case of uncharacterized splicing variants, for proper classification and personalized management of thes…
View article: Lipidomics: advanced analytical technology to identify biomarkers of colorectal cancer
Lipidomics: advanced analytical technology to identify biomarkers of colorectal cancer Open
Lipidomics is an advanced analytical technology applying techniques like Gas-or Liquid Chromatography coupled with Mass Spectrometry or Magnetic Resonance Spectrometry to find the lipid biomarkers in tissues, blood or urine.This review sel…
View article: Metabolomic profile of colorectal cancer patients and its clinical implications
Metabolomic profile of colorectal cancer patients and its clinical implications Open
Background: Colorectal Cancer (CRC) is a great public health issue and the outcomes of treatment depends on early diagnosis. Metabolomics may provide biomarkers for early diagnosis, staging, prognosis and follow-up. Methods: The authors se…