Dan Isbye
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View article: Analgesic Effect of Cocaine and Lidocaine/Xylometazoline in Healthy Volunteers Undergoing Awake Nasal Intubation: A Randomized Controlled Crossover Trial
Analgesic Effect of Cocaine and Lidocaine/Xylometazoline in Healthy Volunteers Undergoing Awake Nasal Intubation: A Randomized Controlled Crossover Trial Open
Background Several drugs may be used to minimize pain during nasal intubation in awake patients. We hypothesized that the analgesic effect of cocaine would be at least as good (non‐inferior) as that of lidocaine with xylometazoline rated a…
View article: Cocaine to prevent bleeding during nasotracheal intubation: A systematic review
Cocaine to prevent bleeding during nasotracheal intubation: A systematic review Open
Background Nasotracheal intubation is associated with a risk of epistaxis. Decongestion of the nasal mucosa reduces the risk of epistaxis, and different vasoconstrictors may be used. Cocaine has both decongestive and analgesic properties, …
View article: Early Restrictive vs Liberal Oxygen for Trauma Patients
Early Restrictive vs Liberal Oxygen for Trauma Patients Open
Importance Early administration of supplemental oxygen for all severely injured trauma patients is recommended, but liberal oxygen treatment has been associated with increased risk of death and respiratory complications. Objective To deter…
View article: Detection of cocaine 24 h after administration before nasotracheal intubation
Detection of cocaine 24 h after administration before nasotracheal intubation Open
Background Cocaine may be applied to decongest the nasal mucosa before nasotracheal intubation, but patients risk a criminal offence if cocaine is detected when patients drive a car shortly after surgery. We aimed to evaluate whether benzo…
View article: Cocaine versus xylometazoline to prevent epistaxis after nasotracheal intubation: A randomized trial
Cocaine versus xylometazoline to prevent epistaxis after nasotracheal intubation: A randomized trial Open
Background Nasotracheal intubation is associated with a risk of epistaxis. Several drugs, including cocaine and xylometazoline may be used as decongestants prior to nasotracheal intubation to prevent this. We hypothesized that xylometazoli…
View article: Using Virtual Reality Head-Mounted Displays to Assess Skills in Emergency Medicine: Validity Study
Using Virtual Reality Head-Mounted Displays to Assess Skills in Emergency Medicine: Validity Study Open
Background Many junior doctors must prepare to manage acutely ill patients in the emergency department. The setting is often stressful, and urgent treatment decisions are needed. Overlooking symptoms and making wrong choices may lead to su…
View article: Using Virtual Reality Head-Mounted Displays to Assess Skills in Emergency Medicine: Validity Study (Preprint)
Using Virtual Reality Head-Mounted Displays to Assess Skills in Emergency Medicine: Validity Study (Preprint) Open
BACKGROUND Many junior doctors must prepare to manage acutely ill patients in the emergency department. The setting is often stressful, and urgent treatment decisions are needed. Overlooking symptoms and making wrong choices may lead to s…
View article: Comparing restrictive versus liberal oxygen strategies for trauma patients — the TRAUMOX2 trial: protocol for a randomised clinical trial
Comparing restrictive versus liberal oxygen strategies for trauma patients — the TRAUMOX2 trial: protocol for a randomised clinical trial Open
Introduction Supplemental oxygen is commonly used in trauma patients, although it may lead to hyperoxaemia that has been associated with pulmonary complications and increased mortality. The primary objective of this trial, TRAUMOX2, is to …
View article: Effect of Vasopressin and Methylprednisolone vs Placebo on Return of Spontaneous Circulation in Patients With In-Hospital Cardiac Arrest
Effect of Vasopressin and Methylprednisolone vs Placebo on Return of Spontaneous Circulation in Patients With In-Hospital Cardiac Arrest Open
ClinicalTrials.gov Identifier: NCT03640949.