Daniel J. Smıth
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View article: Sensitivity of familial high-risk approaches for the identification of future bipolar disorder: A longitudinal total birth cohort study
Sensitivity of familial high-risk approaches for the identification of future bipolar disorder: A longitudinal total birth cohort study Open
Only a small proportion (7.8 %) of BD cases are identified using the FHR-BD approach. Our findings highlight the importance of prediction research investigating not only absolute or relative risk, but also the sensitivity of different appr…
View article: SUN-665 Meta-Analysis of Psychiatric and Quality of Life Outcomes in Patients With Obesity and Diabetes Treated With Glucagon-Like Peptide 1 Receptor Agonists
SUN-665 Meta-Analysis of Psychiatric and Quality of Life Outcomes in Patients With Obesity and Diabetes Treated With Glucagon-Like Peptide 1 Receptor Agonists Open
Disclosure: A.C. Pierret: None. Y. Mizuno: None. P. Saunders: None. E. Lim: None. R. De Giorgi: None. O.D. Howes: None. R.A. McCutcheon: None. B.M. McGowan: None. P. Sen Gupta: None. D. Smith: None. K. Ismail: None. T. Pillinger: None. Bac…
View article: Combined family history and polygenic score prediction of major depressive disorder
Combined family history and polygenic score prediction of major depressive disorder Open
Importance Major depressive disorder (MDD) is a complex psychiatric disorder influenced by genetic, social, and environmental factors. Family history, genome-wide polygenic scores, and childhood trauma are key predictors of MDD onset with …
View article: Modeling human phenotypes in the nematode C. elegans during an undergraduate developmental biology course
Modeling human phenotypes in the nematode C. elegans during an undergraduate developmental biology course Open
Caenorhabditis elegans is a widely used model organism in biomedical research due to its genetic tractability, short life cycle, and conservation of many developmental processes with humans. In this study, undergraduate students conducted …
View article: Estimating Accelerated Retinal Decline in Mental Health Disorders Through Normative Modeling
Estimating Accelerated Retinal Decline in Mental Health Disorders Through Normative Modeling Open
Background and Hypothesis Several studies have found that retinal tissue is thinner in people with mental health disorders than in healthy controls (HC). However, most research has examined group-level differences and has therefore inadequ…
View article: Correction: Depression and physical multimorbidity: A cohort study of physical health condition accrual in UK Biobank
Correction: Depression and physical multimorbidity: A cohort study of physical health condition accrual in UK Biobank Open
[This corrects the article DOI: 10.1371/journal.pmed.1004532.].
View article: Robustly measuring multimorbidity using disparate linked datasets
Robustly measuring multimorbidity using disparate linked datasets Open
Background Measurement of multimorbidity, the co-occurrence of two or more conditions in the same individual, is highly variable which limits the consistency and reproducibility of research. Methods Using data from 172,563 UK Biobank (UKB)…
View article: Impact of the COVID-19 pandemic on incidence of myocardial infarction, heart failure and stroke, by mental disorder diagnosis, in England, 2019–2023: a cohort study
Impact of the COVID-19 pandemic on incidence of myocardial infarction, heart failure and stroke, by mental disorder diagnosis, in England, 2019–2023: a cohort study Open
Background We aimed to estimate mental disorder disparities in cardiovascular disease (CVD) incidence and determine whether these disparities were worsened by the COVID-19 pandemic. Methods For each outcome (myocardial infarction (MI), hea…
View article: Impact of lifestyle in chronic pain and depression: a propensity score analysis in UK biobank
Impact of lifestyle in chronic pain and depression: a propensity score analysis in UK biobank Open
Background Chronic pain and depression are prevalent global health burdens that frequently co-occur, leading to worse outcomes than either condition alone. Current treatments are frequently inadequate, particularly for comorbid chronic pa…
View article: Essential information about chronobiology and chronotherapy for the optimal care of people with bipolar disorders: an international expert consensus
Essential information about chronobiology and chronotherapy for the optimal care of people with bipolar disorders: an international expert consensus Open
Background Circadian dysfunction is involved in the pathophysiology of bipolar disorders (BD), and circadian-based interventions are gaining recognition in their management. Moreover, basic and epidemiologic research has generated findings…
View article: Genome-wide meta-analysis identifies genetic risk factors and implicates multiple body systems in panic attacks and disorder
Genome-wide meta-analysis identifies genetic risk factors and implicates multiple body systems in panic attacks and disorder Open
Introductory paragraph Panic attacks, sudden episodes of intense fear accompanied by physical and psychological symptoms, affect approximately 23% of the population 1,2 . Panic disorder, diagnosed in 2– 4% 3 , involves recurrent attacks fo…
View article: Genetic overlap between functional impairment and depression and anxiety symptom severity: Evidence from the GLAD Study
Genetic overlap between functional impairment and depression and anxiety symptom severity: Evidence from the GLAD Study Open
Background Functional impairment in daily activities, such as work and socialising, is part of the diagnostic criteria for major depressive disorder (MDD) and most anxiety disorders. Despite evidence that symptom severity and functional im…
View article: Affective disorders and chronic inflammatory conditions: analysis of 1.5 million participants in Our Future Health
Affective disorders and chronic inflammatory conditions: analysis of 1.5 million participants in Our Future Health Open
Background Chronic inflammation is associated with psychiatric disorders. If inflammation is linked mechanistically to mental health, people living with chronic inflammatory conditions may experience mental health issues at higher rates th…
View article: Genetic overlap between functional impairment and depression and anxiety symptom severity: Evidence from the GLAD Study
Genetic overlap between functional impairment and depression and anxiety symptom severity: Evidence from the GLAD Study Open
Background Functional impairment in daily activities, such as work and socialising, is part of the diagnostic criteria for major depressive disorder (MDD) and most anxiety disorders. Despite evidence that symptom severity and functional im…
View article: Ambient and passive collection of sleep and circadian data in bipolar disorder to understand symptom trajectories and clinical outcomes (AMBIENT-BD): Study protocol
Ambient and passive collection of sleep and circadian data in bipolar disorder to understand symptom trajectories and clinical outcomes (AMBIENT-BD): Study protocol Open
Bipolar disorder is defined by extreme variability in mood, activity and sleep/wake patterns. To date, studies of sleep and circadian parameters in bipolar disorder have predominantly relied on short term monitoring over 1-2 weeks, leaving…
View article: Time trends in life expectancy of people with severe mental illness in Scotland, 2000–2019: population-based study
Time trends in life expectancy of people with severe mental illness in Scotland, 2000–2019: population-based study Open
Background People with severe mental illness (SMI) have a higher risk of premature mortality than the general population. Aims To investigate whether the life expectancy gap for people with SMI is widening, by determining time trends in ex…
View article: Pramipexole in addition to mood stabilisers for treatment-resistant bipolar depression: the PAX-BD randomised double-blind placebo-controlled trial
Pramipexole in addition to mood stabilisers for treatment-resistant bipolar depression: the PAX-BD randomised double-blind placebo-controlled trial Open
Background There are limited options currently recommended in National Institute for Health and Care Excellence guidelines for the treatment of bipolar depression. Pramipexole has been shown to improve mood symptoms in two small pilot stud…
View article: Modeling human phenotypes in the nematode <i>C. elegans</i> during an undergraduate developmental biology course
Modeling human phenotypes in the nematode <i>C. elegans</i> during an undergraduate developmental biology course Open
Caenorhabditis elegans is a widely used model organism in biomedical research due to its genetic tractability, short life cycle, and conservation of many developmental processes with humans. In this study, undergraduate students conducted …
View article: Affective disorders and chronic inflammatory conditions: Analysis of 1.5 million participants in Our Future Health
Affective disorders and chronic inflammatory conditions: Analysis of 1.5 million participants in Our Future Health Open
Chronic inflammation is associated with psychiatric disorders. If inflammation is linked mechanistically to mental health, people living with chronic inflammatory conditions may experience mental health issues at higher rates than others. …
View article: A pilot study of a ketogenic diet in bipolar disorder: clinical, metabolic and magnetic resonance spectroscopy findings
A pilot study of a ketogenic diet in bipolar disorder: clinical, metabolic and magnetic resonance spectroscopy findings Open
Background Preliminary evidence suggests that a ketogenic diet may be effective for bipolar disorder. Aims To assess the impact of a ketogenic diet in bipolar disorder on clinical, metabolic and magnetic resonance spectroscopy outcomes. Me…
View article: Depression and physical multimorbidity: A cohort study of physical health condition accrual in UK Biobank
Depression and physical multimorbidity: A cohort study of physical health condition accrual in UK Biobank Open
Background Depression is associated with a range of adverse physical health outcomes. We aimed to quantify the association between depression and the subsequent rate of accrual of long-term physical health conditions in middle and older ag…
View article: Co‐production in sleep research: A scoping review of current practices and future directions
Co‐production in sleep research: A scoping review of current practices and future directions Open
Summary Sleep is essential for mental and physical health, and research in the field has substantially expanded over the past 50 years. Co‐production methodology has been increasingly used within health and social care research, and refers…
View article: A randomised double-blind, placebo-controlled trial of pramipexole in addition to mood stabilisers for patients with treatment-resistant bipolar depression (the PAX-BD study)
A randomised double-blind, placebo-controlled trial of pramipexole in addition to mood stabilisers for patients with treatment-resistant bipolar depression (the PAX-BD study) Open
Background: Options for ‘treatment-resistant bipolar depression’ (TRBD) are limited. Two small, short-term, trials of pramipexole suggest it might be an option. Aims: To evaluate the clinical effectiveness and safety of pramipexole in the …
View article: Genetic overlap between functional impairment and depression and anxiety symptom severity: evidence from the GLAD Study
Genetic overlap between functional impairment and depression and anxiety symptom severity: evidence from the GLAD Study Open
Background Functional impairment in daily activities, such as work and socializing, is part of the diagnostic criteria for major depressive disorder and most anxiety disorders. Despite evidence that symptom severity and functional impairme…
View article: Biopsychosocial correlates of body satisfaction in 7- to 8-year old children: a cross-sectional and prospective investigation
Biopsychosocial correlates of body satisfaction in 7- to 8-year old children: a cross-sectional and prospective investigation Open
Background Biopsychosocial factors have been associated with body satisfaction/dissatisfaction and related body image concerns in adolescence; however, few studies have investigated these relationships in middle childhood, an important dev…