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Intravital calcium imaging of meningeal macrophages reveals niche-specific dynamics and aberrant responses to brain hyperexcitability Open

Silvana Gomes Nascimento, Chao Wei, Anna Gu, Dan Levy · 2025

The meninges, which envelop and protect the brain, host a dense network of resident macrophages with diverse roles in regulating homeostasis and neuroinflammation. Despite their importance, we have a limited understanding of their behavior…

Cortical astrocyte activation triggers meningeal nociception and migraine-like pain Open

Dara Bree, Jun Zhao, Jennifer Stratton, Dan Levy · 2025

Migraine attacks are believed to originate in the brain, but the exact mechanisms by which the brain generates peripheral nociceptive signals that drive migraine pain remain unclear. Sensory cortex hyperexcitability has been observed consi…

Author Response: Sensitization of meningeal afferents to locomotion-related meningeal deformations in a migraine model Open

Andrew S Blaeser, Jun Zhao, Arthur U. Sugden, Simone Carneiro-Nascimento, Mark L. Andermann , et al. · 2024

Full text Figures and data Side by side Abstract eLife assessment Introduction Results Discussion Materials and methods Data availability References Peer review Author response Article and author information Abstract Migraine headache is h…

Sensitization of meningeal afferents to locomotion-related meningeal deformations in a migraine model Open

Andrew S Blaeser, Jun Zhao, Arthur U Sugden, Simone Carneiro-Nascimento, Mark L. Andermann , et al. · 2024

Migraine headache is hypothesized to involve the activation and sensitization of trigeminal sensory afferents that innervate the cranial meninges. To better understand migraine pathophysiology and improve clinical translation, we used two-…

Reviewer #1 (Public Review): Sensitization of meningeal afferents to locomotion-related meningeal deformations in a migraine model Open

Andrew S Blaeser, Jun Zhao, Arthur U Sugden, Simone Carneiro-Nascimento, Mark L. Andermann , et al. · 2024

Migraine headache is hypothesized to involve the activation and sensitization of trigeminal sensory afferents that innervate the cranial meninges. To better understand migraine pathophysiology and improve clinical translation, we used two-…

Author Response: Sensitization of meningeal afferents to locomotion-related meningeal deformations in a migraine model Open

Andrew S Blaeser, Jun Zhao, Arthur U. Sugden, Simone Carneiro-Nascimento, Mark L. Andermann , et al. · 2024

Migraine headache is hypothesized to involve the activation and sensitization of trigeminal sensory afferents that innervate the cranial meninges. To better understand migraine pathophysiology and improve clinical translation, we used two-…

Reviewer #2 (Public Review): Sensitization of meningeal afferents to locomotion-related meningeal deformations in a migraine model Open

Andrew S Blaeser, Jun Zhao, Arthur U Sugden, Simone Carneiro-Nascimento, Mark L. Andermann , et al. · 2024

Migraine headache is hypothesized to involve the activation and sensitization of trigeminal sensory afferents that innervate the cranial meninges. To better understand migraine pathophysiology and improve clinical translation, we used two-…

Sensitization of meningeal afferents to locomotion-related meningeal deformations in a migraine model Open

Andrew S Blaeser, Jun Zhao, Arthur U. Sugden, Simone Carneiro-Nascimento, Mark L. Andermann , et al. · 2024

Migraine headache is hypothesized to involve the activation and sensitization of trigeminal sensory afferents that innervate the cranial meninges. To better understand migraine pathophysiology and improve clinical translation, we used two-…

Reviewer #3 (Public Review): Sensitization of meningeal afferents to locomotion-related meningeal deformations in a migraine model Open

Andrew S Blaeser, Jun Zhao, Arthur U Sugden, Simone Carneiro-Nascimento, Mark L. Andermann , et al. · 2024

Migraine headache is hypothesized to involve the activation and sensitization of trigeminal sensory afferents that innervate the cranial meninges. To better understand migraine pathophysiology and improve clinical translation, we used two-…

CGRP signalling in migraine: time to look downstream? Open

Dan Levy · 2023

This scientific commentary refers to ‘Second messenger signalling bypasses CGRP receptor blockade to provoke migraine attacks in humans’ by Do et al. (https://doi.org/10.1093/brain/awad261).

Reviewer #3 (Public Review): Sensitization of meningeal afferents to locomotion-related meningeal deformations in a migraine model Open

Andrew S Blaeser, Jun Zhao, Arthur U Sugden, Simone Carneiro-Nascimento, Mark L. Andermann , et al. · 2023

Migraine headache is hypothesized to involve the activation and sensitization of trigeminal sensory afferents that innervate the cranial meninges. To better understand migraine pathophysiology and improve clinical translation, we used two-…

Reviewer #1 (Public Review): Sensitization of meningeal afferents to locomotion-related meningeal deformations in a migraine model Open

Andrew S Blaeser, Jun Zhao, Arthur U. Sugden, Simone Carneiro-Nascimento, Mark L. Andermann , et al. · 2023

Migraine headache is hypothesized to involve the activation and sensitization of trigeminal sensory afferents that innervate the cranial meninges. To better understand migraine pathophysiology and improve clinical translation, we used two-…

Reviewer #2 (Public Review): Sensitization of meningeal afferents to locomotion-related meningeal deformations in a migraine model Open

Andrew S Blaeser, Jun Zhao, Arthur U. Sugden, Simone Carneiro-Nascimento, Mark L. Andermann , et al. · 2023

Migraine headache is hypothesized to involve the activation and sensitization of trigeminal sensory afferents that innervate the cranial meninges. To better understand migraine pathophysiology and improve clinical translation, we used two-…

Sensitization of meningeal afferents to locomotion-related meningeal deformations in a migraine model Open

Andrew S Blaeser, Jun Zhao, Arthur U. Sugden, Simone Carneiro-Nascimento, Mark L. Andermann , et al. · 2023

Migraine headache is hypothesized to involve the activation and sensitization of trigeminal sensory afferents that innervate the cranial meninges. To better understand migraine pathophysiology and improve clinical translation, we used two-…

Sensitization of meningeal afferents to locomotion-related meningeal deformations in a migraine model Open

Andrew S Blaeser, Jun Zhao, Arthur U. Sugden, Simone Carneiro-Nascimento, Mark L. Andermann , et al. · 2023

Migraine headache is hypothesized to involve the activation and sensitization of trigeminal sensory afferents that innervate the cranial meninges. To better understand migraine pathophysiology and improve clinical translation, we used two-…

Sensitization of meningeal afferents to locomotion-related meningeal deformations in a migraine model Open

Andrew S Blaeser, Jun Zhao, Arthur U Sugden, Simone Carneiro-Nascimento, Mark L. Andermann , et al. · 2023

Migraine headache is hypothesized to involve the activation and sensitization of trigeminal sensory afferents that innervate the cranial meninges. To better understand migraine pathophysiology and improve clinical translation, we used two-…

Meningeal P2X7 Signaling Mediates Migraine-Related Intracranial Mechanical Hypersensitivity Open

Jun Zhao, Samantha Harrison, Dan Levy · 2023

Cortical spreading depolarization (CSD) is a key pathophysiological event that underlies visual and sensory auras in migraine. CSD is also thought to drive the headache phase in migraine by promoting the activation and mechanical sensitiza…

Meningeal Mechanisms and the Migraine Connection Open

Dan Levy, Michael A. Moskowitz · 2023

Migraine is a complex neurovascular pain disorder linked to the meninges, a border tissue innervated by neuropeptide-containing primary afferent fibers chiefly from the trigeminal nerve. Electrical or mechanical stimulation of this nerve s…

Bacteria hijack a meningeal neuroimmune axis to facilitate brain invasion Open

Felipe A. Pinho‐Ribeiro, Liwen Deng, Dylan V. Neel, Özge Erdoğan, Himanish Basu , et al. · 2023

Meningeal P2X7 signaling mediates migraine-related intracranial mechanical hypersensitivity Open

Jun Zhao, Samantha Harrison, Dan Levy · 2023

Cortical spreading depolarization (CSD) is a key pathophysiological event that underlies visual and sensory auras in migraine. CSD is also thought to drive the headache phase in migraine by promoting the activation and mechanical sensitiza…

Trigeminal afferents sense locomotion-related meningeal deformations Open

Andrew S Blaeser, Arthur U. Sugden, Jun Zhao, Simone Carneiro-Nascimento, Frederick B. Shipley , et al. · 2022

The trigeminal sensory innervation of the cranial meninges is thought to serve a nociceptive function and mediate headache pain. However, the activity of meningeal afferents under natural conditions in awake animals remains unexplored. Her…

Human and mouse trigeminal ganglia cell atlas implicates multiple cell types in migraine Open

Lite Yang, Mengyi Xu, Shamsuddin A. Bhuiyan, Jia Li, Jun Zhao , et al. · 2022

Bacteria hijack a neuro-immune axis in the meninges to facilitate brain invasion Open

Isaac M. Chiu, Felipe A. Pinho‐Ribeiro, Liwen Deng, Dylan V. Neel, Özge Erdoğan , et al. · 2022

The meninges are densely innervated by nociceptors that mediate pain and headache. Bacterial meningitis is a life-threatening infection of the meninges and central nervous system (CNS) that affects over one million people a year. However, …

Meningeal Afferents Sense Locomotion-Related Mechanical Deformations and Cortical Spreading Depression Open

Andrew S Blaeser, Arthur U. Sugden, Jun Zhao, Fred Shipley, Hanaé Carrié , et al. · 2022

Cortical spreading depression and meningeal nociception Open

Simone Carneiro-Nascimento, Dan Levy · 2022

Can transparency and accountability programs improve health? Experimental evidence from Indonesia and Tanzania Open

Jean Arkedis, Jessica Creighton, Akshay Dixit, Archon Fung, Stephen Kosack , et al. · 2021

We assess the impact of a transparency and accountability program designed to improve maternal and newborn health (MNH) outcomes in Indonesia and Tanzania. Co-designed with local partner organizations to be community-led and non-prescripti…

Astrocytes mediate migraine-related intracranial meningeal mechanical hypersensitivity Open

Jun Zhao, Andrew S Blaeser, Dan Levy · 2021

The genesis of the headache phase in migraine with aura is thought to be mediated by cortical spreading depression (CSD) and the subsequent activation and sensitization of primary afferent neurons that innervate the intracranial meninges a…

Can transparency and accountability programs improve health? Experimental evidence from Indonesia and Tanzania Open

Jean Arkedis, Jessica Creighton, Akshay Dixit, Archon Fung, Stephen Kosack , et al. · 2020

We assess the impact of a transparency and accountability program designed to improve maternal and newborn health (MNH) outcomes in Indonesia and Tanzania. Co-designed with local partner organizations to be community-led and non-prescripti…

Author Correction: Bone Anabolic Response in the Calvaria Following Mild Traumatic Brain Injury is Mediated by the Cannabinoid-1 Receptor Open

Michelle Nascimento Meger, Miaad Bader, Dara Bree, Rivka Hadar, Alina Nemirovski , et al. · 2020

Increased severity of closed head injury or repetitive subconcussive head impacts enhances post-traumatic headache-like behaviors in a rat model Open

Dara Bree, Jennifer Stratton, Dan Levy · 2020

Introduction Posttraumatic headache is one of the most common, debilitating, and difficult symptoms to manage after a traumatic head injury. The development of novel therapeutic approaches is nevertheless hampered by the paucity of preclin…

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