Dan Ruan
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View article: IMG-116. Diffusion-Relaxation Correlation Spectroscopic Imaging Differentiates Brain Tumor Progression and Treatment Effects: a Pilot Study
IMG-116. Diffusion-Relaxation Correlation Spectroscopic Imaging Differentiates Brain Tumor Progression and Treatment Effects: a Pilot Study Open
INTRODUCTION Differentiating treatment effects (TxE), including cases with radiation necrosis and/or with gliosis and hyalinized vessels on histopathology, from tumor progression in irradiated brain tumors remains a clinical challenge due …
View article: Multiple source-to-isocenter-distance (SID) optimization for 4 <i>π</i> robotic radiotherapy
Multiple source-to-isocenter-distance (SID) optimization for 4 <i>π</i> robotic radiotherapy Open
While 4 π radiotherapy has shown dosimetric advantages over coplanar delivery, prior studies have assumed a fixed source-to-isocenter distance (SID), as varying SID is cumbersome to implement on conventional C-arm linacs. Radiotherapy plat…
View article: Generation of Synthetic scRNA-seq-Like Transcriptomes Using a Generative Adversarial Network from RNA-seq Data
Generation of Synthetic scRNA-seq-Like Transcriptomes Using a Generative Adversarial Network from RNA-seq Data Open
Next-generation sequencing (NGS) technologies have become integral for high-throughput transcriptomic studies. Among these, single-cell RNA sequencing (scRNA-seq) is especially valuable for quantifying gene expression at the individual cel…
View article: DuEL-Med: A Dual-Path Enhanced Language Model for Clinically-Aware Radiology Report Generation
DuEL-Med: A Dual-Path Enhanced Language Model for Clinically-Aware Radiology Report Generation Open
View article: Therapeutic medical physicist well‐being and employment satisfaction during the COVID‐19 pandemic in California
Therapeutic medical physicist well‐being and employment satisfaction during the COVID‐19 pandemic in California Open
Purpose This study aims to investigate medical physicist job status during the COVID‐19 pandemic in California and collect community feedback on strategies to alleviate job burnout and stress to improve overall work‐life balance. Methods a…
View article: TomoGRAF: An X-ray physics-driven generative radiance field framework for extremely sparse view CT reconstruction
TomoGRAF: An X-ray physics-driven generative radiance field framework for extremely sparse view CT reconstruction Open
Objectives Computed tomography (CT) provides high spatial-resolution visualization of 3D structures for various applications. Traditional analytical/iterative CT reconstruction algorithms require hundreds of angular samplings, a condition …
View article: NIRA-04 DIFFERENTIATION OF BRAIN TUMOR PROGRESSION AND TREATMENT EFFECT USING DIFFUSION-RELAXATION CORRELATION SPECTROSCOPIC IMAGING
NIRA-04 DIFFERENTIATION OF BRAIN TUMOR PROGRESSION AND TREATMENT EFFECT USING DIFFUSION-RELAXATION CORRELATION SPECTROSCOPIC IMAGING Open
Differentiating treatment effects (TxE) from tumor progression in glioma and metastatic brain tumors is challenging due to their similar clinical presentations and conventional MRI characteristics. Scenarios with mixed pathology further co…
View article: An ultra-high performance parallel (UHPP) framework for complex 4<i>π</i> radiotherapy planning
An ultra-high performance parallel (UHPP) framework for complex 4<i>π</i> radiotherapy planning Open
Purpose . In radiotherapy, dose distribution conformity and compactness are critical to patient outcomes. Advanced techniques like radiotherapy leverage non-coplanar beams for superior dosimetry by exploring additional degrees of freed…
View article: A clustering‐based approach to address correlated features in predicting genitourinary toxicity from MRI‐guided prostate SBRT
A clustering‐based approach to address correlated features in predicting genitourinary toxicity from MRI‐guided prostate SBRT Open
Background It is common in outcome analysis to work with a large set of candidate prognostic features. However, such high‐dimensional input and relatively small sample size leads to risk of overfitting, low generalizability, and correlatio…
View article: Benchmark of Segmentation Techniques for Pelvic Fracture in CT and X-ray: Summary of the PENGWIN 2024 Challenge
Benchmark of Segmentation Techniques for Pelvic Fracture in CT and X-ray: Summary of the PENGWIN 2024 Challenge Open
The segmentation of pelvic fracture fragments in CT and X-ray images is crucial for trauma diagnosis, surgical planning, and intraoperative guidance. However, accurately and efficiently delineating the bone fragments remains a significant …
View article: Complementarity-Oriented Feature Fusion for Face-Phone Trajectory Matching
Complementarity-Oriented Feature Fusion for Face-Phone Trajectory Matching Open
CCTVs and telecom base stations act as sensors, and collect massive face and phone related data. When used for person localization and trajectory characterization, they each present quite different spatiotemporal characteristics: CCTV is a…
View article: Perturbed Resonance Frequency Analysis for Imaging Epidermal Thickness and Water Content Using Terahertz Spectroscopy
Perturbed Resonance Frequency Analysis for Imaging Epidermal Thickness and Water Content Using Terahertz Spectroscopy Open
View article: TomoGRAF: A Robust and Generalizable Reconstruction Network for Single-View Computed Tomography
TomoGRAF: A Robust and Generalizable Reconstruction Network for Single-View Computed Tomography Open
Computed tomography (CT) provides high spatial resolution visualization of 3D structures for scientific and clinical applications. Traditional analytical/iterative CT reconstruction algorithms require hundreds of angular data samplings, a …
View article: <sup>68</sup>Ga-FAPI-46 PET/CT in the evaluation of gliomas: comparison with <sup>18</sup>F-FDG PET/CT and contrast-enhanced MRI
<sup>68</sup>Ga-FAPI-46 PET/CT in the evaluation of gliomas: comparison with <sup>18</sup>F-FDG PET/CT and contrast-enhanced MRI Open
Rationale: This study compared 68Ga-FAPI-46 PET/CT, 18F-fluorodeoxyglucose (FDG) PET/CT, and contrast-enhanced MRI (CE-MRI) for glioma imaging, classification, and recurrence detection and explored PET p…
View article: Necessity and impact of specialization of large foundation model for medical segmentation tasks
Necessity and impact of specialization of large foundation model for medical segmentation tasks Open
Background Large foundation models, such as the Segment Anything Model (SAM), have shown remarkable performance in image segmentation tasks. However, the optimal approach to achieve true utility of these models for domain‐specific applicat…
View article: Metric learning guided sinogram denoising for cone beam CT enhancement
Metric learning guided sinogram denoising for cone beam CT enhancement Open
Background Cone beam computed tomography (CBCT) is a widely available modality, but its clinical utility has been limited by low detail conspicuity and quantitative accuracy. Convenient post‐reconstruction denoising is subject to back proj…
View article: Necessity and Impact of Specialization of Large Foundation Model for Medical Segmentation Tasks
Necessity and Impact of Specialization of Large Foundation Model for Medical Segmentation Tasks Open
Background Large foundation models, such as the Segment Anything Model (SAM), have shown remarkable performance in image segmentation tasks. However, the optimal approach to achieve true utility of these models for domain-specific applicat…
View article: Simultaneous Deep Learning of Myocardium Segmentation and T2 Quantification for Acute Myocardial Infarction MRI
Simultaneous Deep Learning of Myocardium Segmentation and T2 Quantification for Acute Myocardial Infarction MRI Open
In cardiac Magnetic Resonance Imaging (MRI) analysis, simultaneous myocardial segmentation and T2 quantification are crucial for assessing myocardial pathologies. Existing methods often address these tasks separately, limiting their synerg…
View article: Hypoxia‐informed RBE‐weighted beam orientation optimization for intensity modulated proton therapy
Hypoxia‐informed RBE‐weighted beam orientation optimization for intensity modulated proton therapy Open
Background Variable relative biological effectiveness (RBE) models in treatment planning have been proposed to optimize the therapeutic ratio of proton therapy. It has been reported that proton RBE decreases with increasing tumor oxygen le…
View article: (016) Sexual Health Toxicity Following MRI-Guided versus CT-guided Prostate SBRT
(016) Sexual Health Toxicity Following MRI-Guided versus CT-guided Prostate SBRT Open
Introduction Sexual health toxicities remain an under-reported but important health outcome for patients undergoing radiotherapy for localized prostate cancer. With the increasing adoption of higher daily doses of radiation over shorter ti…
View article: ECG‐free cine MRI with data‐driven clustering of cardiac motion for quantification of ventricular function
ECG‐free cine MRI with data‐driven clustering of cardiac motion for quantification of ventricular function Open
Background Despite the widespread use of cine MRI for evaluation of cardiac function, existing real‐time methods do not easily enable quantification of ventricular function. Moreover, segmented cine MRI assumes periodicity of cardiac motio…
View article: Dynamic Regularized Adaptive Cluster Optimization (DRACO) for Cardiac Cine MRI in Complex Arrhythmias
Dynamic Regularized Adaptive Cluster Optimization (DRACO) for Cardiac Cine MRI in Complex Arrhythmias Open
View article: A Two-Step Framework for Multi-Material Decomposition of Dual Energy Computed Tomography from Projection Domain
A Two-Step Framework for Multi-Material Decomposition of Dual Energy Computed Tomography from Projection Domain Open
Dual-energy computed tomography (DECT) utilizes separate X-ray energy spectra to improve multi-material decomposition (MMD) for various diagnostic applications. However accurate decomposing more than two types of material remains challengi…
View article: Hypoxia Informed RBE-Weighted Beam Orientation Optimization for Intensity Modulated Proton Therapy Using [18F]-FMISO-PET Estimation of pO2
Hypoxia Informed RBE-Weighted Beam Orientation Optimization for Intensity Modulated Proton Therapy Using [18F]-FMISO-PET Estimation of pO2 Open
View article: Learning Dynamic MRI Reconstruction with Convolutional Network Assisted Reconstruction Swin Transformer
Learning Dynamic MRI Reconstruction with Convolutional Network Assisted Reconstruction Swin Transformer Open
Dynamic magnetic resonance imaging (DMRI) is an effective imaging tool for diagnosis tasks that require motion tracking of a certain anatomy. To speed up DMRI acquisition, k-space measurements are commonly undersampled along spatial or spa…
View article: A quantitative CBCT pipeline based on 2D antiscatter grid and grid‐based scatter sampling for image‐guided radiation therapy
A quantitative CBCT pipeline based on 2D antiscatter grid and grid‐based scatter sampling for image‐guided radiation therapy Open
Background Quantitative accuracy is critical for expanding the role of cone beam CT (CBCT) imaging from target localization to quantitative treatment monitoring and plan adaptations in radiation therapy. Despite advances in CBCT image qual…
View article: Analytical HDR prostate brachytherapy planning with automatic catheter and isotope selection
Analytical HDR prostate brachytherapy planning with automatic catheter and isotope selection Open
Background High dose rate (HDR) brachytherapy is commonly used to treat prostate cancer. Existing HDR planning systems solve the dwell time problem for predetermined catheters and a single energy source. Purpose Additional degrees of freed…
View article: 2D antiscatter grid and scatter sampling based CBCT pipeline for image guided radiation therapy
2D antiscatter grid and scatter sampling based CBCT pipeline for image guided radiation therapy Open
Poor tissue visualization and quantitative accuracy in CBCT is a major barrier in expanding the role of CBCT imaging from target localization to quantitative treatment monitoring and plan adaptations in radiation therapy sessions. To furth…
View article: 2D antiscatter grid and scatter sampling based CBCT pipeline for image guided radiation therapy.
2D antiscatter grid and scatter sampling based CBCT pipeline for image guided radiation therapy. Open
Poor tissue visualization and quantitative accuracy in CBCT is a major barrier in expanding the role of CBCT imaging from target localization to quantitative treatment monitoring and plan adaptations in radiation therapy sessions. To furth…
View article: Operational Ontology for Oncology (O3): A Professional Society-Based, Multistakeholder, Consensus-Driven Informatics Standard Supporting Clinical and Research Use of Real-World Data From Patients Treated for Cancer
Operational Ontology for Oncology (O3): A Professional Society-Based, Multistakeholder, Consensus-Driven Informatics Standard Supporting Clinical and Research Use of Real-World Data From Patients Treated for Cancer Open