Dan Longrois
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View article: Compliance with ESAIC guidelines for fibrinogen concentrate prescription in cardiac surgery: a multicentre French cohort study
Compliance with ESAIC guidelines for fibrinogen concentrate prescription in cardiac surgery: a multicentre French cohort study Open
Clinicaltrials.gov identifier: (NCT03075774).
View article: Perioperative hemodynamic optimization - Paediatrics
Perioperative hemodynamic optimization - Paediatrics Open
Nine guidelines, with a high degree of agreement between experts, on perioperative hemodynamic optimization have been formulated.
View article: Perioperative hemodynamic optimization - Adults including obstetrics
Perioperative hemodynamic optimization - Adults including obstetrics Open
24 guidelines on perioperative haemodynamic optimization have been formulated, with a high degree of agreement between experts.
View article: Association between preoperative uric acid concentration and the occurrence of atrial fibrillation following cardiac surgery: an observational prospective study
Association between preoperative uric acid concentration and the occurrence of atrial fibrillation following cardiac surgery: an observational prospective study Open
The preoperative UA concentration was independently associated with the occurrence of POAF after CABG but not after valve surgery. PCA results indicate that different biological profiles contribute to POAF occurrence according to the type …
View article: Combining O<sub>2</sub> High Flow Nasal or Non-Invasive Ventilation with Cooperative Sedation to Avoid Intubation in Early Diffuse Severe Respiratory Distress Syndrome, Especially in Immunocompromised or COVID Patients?
Combining O<sub>2</sub> High Flow Nasal or Non-Invasive Ventilation with Cooperative Sedation to Avoid Intubation in Early Diffuse Severe Respiratory Distress Syndrome, Especially in Immunocompromised or COVID Patients? Open
This overview addresses the pathophysiology of the acute respiratory distress syndrome (ARDS; conventional vs. COVID), the use of oxygen high flow (HFN) vs. noninvasive ventilation (NIV; conventional vs. helmet) and a multi-modal approach …
View article: Divergent effects of tumor necrosis factor (TNF) in sepsis: a meta-analysis of experimental studies
Divergent effects of tumor necrosis factor (TNF) in sepsis: a meta-analysis of experimental studies Open
The role of TNF during infection varies depending on the experimental model used. Models that mimic clinical conditions, based on virulent bacteria that cause high mortality even at low inocula, demonstrated an adaptive role of TNF. Conver…
View article: Continuation vs Discontinuation of Renin-Angiotensin System Inhibitors Before Major Noncardiac Surgery
Continuation vs Discontinuation of Renin-Angiotensin System Inhibitors Before Major Noncardiac Surgery Open
Importance Before surgery, the best strategy for managing patients who are taking renin-angiotensin system inhibitors (RASIs) (angiotensin-converting enzyme inhibitors or angiotensin receptor blockers) is unknown. The lack of evidence lead…
View article: TNF: Friend or foe in sepsis? A meta-analysis of experimental studies
TNF: Friend or foe in sepsis? A meta-analysis of experimental studies Open
Introduction Experimental studies in animals have yielded conflicting results on the role of Tumor Necrosis Factor (TNF) in sepsis, with some reporting protective effects and others reporting deleterious effects. To determine the factors t…
View article: Circulating microbiome analysis in patients with perioperative anaphylaxis
Circulating microbiome analysis in patients with perioperative anaphylaxis Open
Background Perioperative anaphylaxis is a rare and acute systemic manifestation of drug-induced hypersensitivity reactions that occurs following anesthesia induction; the two main classes of drugs responsible for these reactions being neur…
View article: Mapping general anesthesia states based on electro-encephalogram transition phases
Mapping general anesthesia states based on electro-encephalogram transition phases Open
Cortical electro-encephalography (EEG) served as the clinical reference for monitoring unconsciousness during general anesthesia. The existing EEG-based monitors classified general anesthesia states as underdosed, adequate, or overdosed, l…
View article: Mapping general anesthesia states based on electro-encephalogram transition phases
Mapping general anesthesia states based on electro-encephalogram transition phases Open
Background: Cortical electro-encephalography (EEG) has become the clinical reference for monitoring unconsciousness during general anesthesia. The current EEG-based monitors classify general anesthesia states simply as underdosed, adequate…
View article: Mapping general anesthesia states based on electro-encephalogram transition phases
Mapping general anesthesia states based on electro-encephalogram transition phases Open
Background: Cortical electro-encephalography (EEG) has become the clinical reference for monitoring unconsciousness during general anesthesia. The current EEG-based monitors classify general anesthesia states simply as underdosed, adequate…
View article: Rotational Thromboelastometry Coagulation Parameters (ROTEM®) May be Discriminative for Active Inflammatory Bowel Disease: A Prospective Observational Study
Rotational Thromboelastometry Coagulation Parameters (ROTEM®) May be Discriminative for Active Inflammatory Bowel Disease: A Prospective Observational Study Open
Background and Aims: Inflammatory bowel disease (IBD) is associated with increased risk of thromboembolic events. The rotational thromboelastometry (ROTEM®) is a validated integrative assessment of coagulation, but it has never been studie…
View article: Improved understanding of the respiratory drive pathophysiology could lead to earlier spontaneous breathing in severe acute respiratory distress syndrome
Improved understanding of the respiratory drive pathophysiology could lead to earlier spontaneous breathing in severe acute respiratory distress syndrome Open
Optimisation of the respiratory drive, as early as possible in the setting of severe acute respiratory distress syndrome (ARDS) and not its suppression, could be a new paradigm in the management of severe forms of ARDS. Severe ARDS is char…
View article: Un-supervised classification of ICU patients according to congestion endotypes identifies clinical profiles associated with distinct outcomes: theCodOrea study.
Un-supervised classification of ICU patients according to congestion endotypes identifies clinical profiles associated with distinct outcomes: theCodOrea study. Open
Purpose In the intensive care unit (ICU), fluid overload and congestion is of daily concern. To date, congestion is defined as the linear evolution of several features, including hemodynamic and ultrasound parameters. Nevertheless, at beds…
View article: Mapping general anesthesia states based on electro-encephalogram transition phases
Mapping general anesthesia states based on electro-encephalogram transition phases Open
Cortical electro-encephalography (EEG) has become the clinical reference for monitoring unconsciousness during general anesthesia. The current EEG-based monitors classify general anesthesia states simply as underdosed, adequate, or overdos…
View article: ESAIC focused guideline for the use of cardiac biomarkers in perioperative risk evaluation
ESAIC focused guideline for the use of cardiac biomarkers in perioperative risk evaluation Open
BACKGROUND In recent years, there has been increasing focus on the use of cardiac biomarkers in patients undergoing noncardiac surgery. AIMS The aim of this focused guideline was to provide updated guidance regarding the pre-, post- and co…
View article: Pholcodine exposure increases the risk of perioperative anaphylaxis to neuromuscular blocking agents: the ALPHO case-control study
Pholcodine exposure increases the risk of perioperative anaphylaxis to neuromuscular blocking agents: the ALPHO case-control study Open
NCT02250729.
View article: Spectral EEG correlations from the different phases of general anesthesia
Spectral EEG correlations from the different phases of general anesthesia Open
Introduction Electroencephalography (EEG) signals contain transient oscillation patterns commonly used to classify brain states in responses to action, sleep, coma or anesthesia. Methods Using a time-frequency analysis of the EEG, we searc…
View article: The COVID-19 Vaccination Coverage in ICU Patients with Severe COVID-19 Infection in a Country with Low Vaccination Coverage—A National Retrospective Analysis
The COVID-19 Vaccination Coverage in ICU Patients with Severe COVID-19 Infection in a Country with Low Vaccination Coverage—A National Retrospective Analysis Open
Background: Romania is one of the European countries with low COVID-19 vaccination coverage. The main goal of this study was to describe the COVID-19 vaccination status in patients admitted to Romanian ICUs with a severe COVID-19 infection…
View article: Pholcodine consumption increases the risk of perioperative anaphylaxis to neuromuscular blocking agents: the ALPHO case-control study
Pholcodine consumption increases the risk of perioperative anaphylaxis to neuromuscular blocking agents: the ALPHO case-control study Open
Background Neuromuscular blocking agents (NMBAs) are the leading cause of perioperative anaphylaxis (POA), most reactions being IgE mediated. Allergic sensitization induced by environmental exposure to other quaternary ammonium-containing …
View article: Peri-operative management of neuromuscular blockade
Peri-operative management of neuromuscular blockade Open
Recent data indicated a high incidence of inappropriate management of neuromuscular block, with a high rate of residual paralysis and relaxant-associated postoperative complications. These data are alarming in that the available neuromuscu…
View article: Statistical segmentation and correlation analysis of the EEG between the different phases of general anesthesia
Statistical segmentation and correlation analysis of the EEG between the different phases of general anesthesia Open
Electroencephalography (EEG) is routinely used to monitor general anesthesia (GA). Unanswered questions concern the possibility of using the EEG signal to classify patients as more or less sensitive to anesthetic drugs from the onset of an…
View article: Syndecan-1 Is Overexpressed in Human Thoracic Aneurysm but Is Dispensable for the Disease Progression in a Mouse Model
Syndecan-1 Is Overexpressed in Human Thoracic Aneurysm but Is Dispensable for the Disease Progression in a Mouse Model Open
Glycosaminoglycans (GAGs) pooling has long been considered as one of the histopathological characteristics defining thoracic aortic aneurysm (TAA) together with smooth muscle cells (SMCs) apoptosis and elastin fibers degradation. However, …