Dan Miléa
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View article: Glaucomatous, Glaucoma-Like, and Non-Glaucomatous Optic Neuropathy in High Myopia: The Two-Continent Study
Glaucomatous, Glaucoma-Like, and Non-Glaucomatous Optic Neuropathy in High Myopia: The Two-Continent Study Open
Highly myopic eyes had considerable prevalences of NGON and GLON/GON, usually higher than 20% and 10%, respectively. The single IOP reading was ≤21 millimeters of mercury (mm Hg) in ≥70% of the eyes with GLON/GON. NGON (associated with lar…
View article: Recovery in pupillometric non-visual functions following chiasmal decompression in pituitary adenoma
Recovery in pupillometric non-visual functions following chiasmal decompression in pituitary adenoma Open
Background This study investigates visual and non-visual ( i.e., pupillometric) changes associated with optic nerve compression and decompression, and the potential role of chromatic pupillometry as an objective evaluation tool for visual …
View article: Visual Prostheses in the Era of Artificial Intelligence Technology
Visual Prostheses in the Era of Artificial Intelligence Technology Open
AI algorithms show promise in optimizing prosthetic vision, particularly through enhanced image saliency extraction and stimulation strategies. However, most current studies are based on simulations. Further development and validation in r…
View article: Artificial Intelligence‐Based Detection of Central Retinal Artery Occlusion Within 4.5 Hours on Standard Fundus Photographs
Artificial Intelligence‐Based Detection of Central Retinal Artery Occlusion Within 4.5 Hours on Standard Fundus Photographs Open
Background Prompt diagnosis of acute central retinal artery occlusion (CRAO) is crucial for therapeutic management and stroke prevention. However, most stroke centers lack onsite ophthalmic expertise before considering fibrinolytic treatme…
View article: Peripapillary Hyperreflective Ovoid Mass-Like Structures: Prevalence and Associations in the Adult Population of the Beijing Eye Study
Peripapillary Hyperreflective Ovoid Mass-Like Structures: Prevalence and Associations in the Adult Population of the Beijing Eye Study Open
PHOMS are relatively rare in the general adult and elderly population and mainly associated with a small optic disc. They are not related to a decrease in visual function or peripapillary retinal nerve fiber layer thickness, and they do no…
View article: Psychometric evaluation and computerized adaptive testing simulations of age-related macular degeneration quality of life item banks
Psychometric evaluation and computerized adaptive testing simulations of age-related macular degeneration quality of life item banks Open
Six IBs demonstrated acceptable psychometric properties and potential CAT efficiency, suggesting MacCAT provides a comprehensive measurement of the QoL impact of AMD and associated treatments. Further testing in larger clinical cohorts is …
View article: Recent advances in neuro-ophthalmology
Recent advances in neuro-ophthalmology Open
This review article represents a collaborative effort across continents, bringing together the latest developments in neuro-ophthalmology with a focus on innovative diagnostic and therapeutic modalities that are shaping the future of the f…
View article: Optical coherence tomography angiography of the retina and choroid in systemic diseases
Optical coherence tomography angiography of the retina and choroid in systemic diseases Open
Optical coherence tomography angiography (OCTA) has transformed ocular vascular imaging, revealing microvascular changes linked to various systemic diseases. This review explores its applications in diabetes, hypertension, cardiovascular d…
View article: Value proposition of retinal imaging in Alzheimer's disease screening: A review of eight evolving trends
Value proposition of retinal imaging in Alzheimer's disease screening: A review of eight evolving trends Open
View article: Genetic susceptibility to optic neuropathy in patients with alcohol use disorder
Genetic susceptibility to optic neuropathy in patients with alcohol use disorder Open
View article: Reply: Stroke-like episode of the optic nerve
Reply: Stroke-like episode of the optic nerve Open
View article: Seven, a Magic Number
Seven, a Magic Number Open
View article: Are isolated ocular motor nerve palsies in the elderly truly ‘low risk’ for abnormal neuro-imaging outcomes?
Are isolated ocular motor nerve palsies in the elderly truly ‘low risk’ for abnormal neuro-imaging outcomes? Open
View article: Content development of the VISION-Cog: a novel tool to assess cognitive impairment in visually impaired older adults in Singapore
Content development of the VISION-Cog: a novel tool to assess cognitive impairment in visually impaired older adults in Singapore Open
Objectives Current cognitive screening and diagnostic instruments rely on visually dependent tasks and are, therefore, not suitable to assess cognitive impairment (CI) in visually impaired older adults. We describe the content development …
View article: Feasibility, comprehensibility and acceptability of the VISION-Cog, a novel tool to assess cognitive impairment in visually impaired older adults: a cross-sectional pilot study in Singapore
Feasibility, comprehensibility and acceptability of the VISION-Cog, a novel tool to assess cognitive impairment in visually impaired older adults: a cross-sectional pilot study in Singapore Open
Objectives We pilot-tested the VIS ually I ndependent test battery O f N euro COG nition (VISION-Cog) to determine its feasibility, comprehensibility and acceptability in evaluating cognitive impairment (CI) in visually impaired older Asia…
View article: AI-based diagnosis in mandibulofacial dysostosis with microcephaly using external ear shapes
AI-based diagnosis in mandibulofacial dysostosis with microcephaly using external ear shapes Open
Introduction Mandibulo-Facial Dysostosis with Microcephaly (MFDM) is a rare disease with a broad spectrum of symptoms, characterized by zygomatic and mandibular hypoplasia, microcephaly, and ear abnormalities. Here, we aimed at describing …
View article: A Deep Learning Approach to Accurately Discriminate Between Optic Disc Drusen and Papilledema on Fundus Photographs
A Deep Learning Approach to Accurately Discriminate Between Optic Disc Drusen and Papilledema on Fundus Photographs Open
Objective To assess the performance of a deep learning system (DLS) to discriminate between optic disc drusen (ODD) and papilledema caused by intracranial hypertension, using standard color ocular fundus photographs collected in a large in…
View article: A Duration-Dependent Interaction Between High-Intensity Light and Unrestricted Vision in the Drive for Myopia Control
A Duration-Dependent Interaction Between High-Intensity Light and Unrestricted Vision in the Drive for Myopia Control Open
Daily exposure to 2, 4, or 6 hours of HL, UnV, or HL + UnV reduced lens-induced myopic refraction in a duration-dependent manner in chickens. Only 6 hours of HL + UnV completely stopped LIM development. The synergetic effect of HL and UnV …
View article: Through the eyes into the brain, using artificial intelligence
Through the eyes into the brain, using artificial intelligence Open
Introduction: Detection of neurological conditions is of high importance in the current context of increasingly ageing populations. Imaging of the retina and the optic nerve head represents a unique opportunity to detect brain diseases, bu…
View article: A Deep Learning System for Automated Quality Evaluation of Optic Disc Photographs in Neuro-Ophthalmic Disorders
A Deep Learning System for Automated Quality Evaluation of Optic Disc Photographs in Neuro-Ophthalmic Disorders Open
The quality of ocular fundus photographs can affect the accuracy of the morphologic assessment of the optic nerve head (ONH), either by humans or by deep learning systems (DLS). In order to automatically identify ONH photographs of optimal…
View article: Current and Emerging Therapies for Leber Hereditary Optic Neuropathy
Current and Emerging Therapies for Leber Hereditary Optic Neuropathy Open
Leber hereditary optic neuropathy (LHON) is the most common primary mitochondrial DNA disorder, presenting typically as a sequential, painless, subacute, optic neuropathy in young males. Despite the very limited therapeutic options in LHON…
View article: A duration-dependent interaction between high-intensity light and optical refocus in the drive for myopia control
A duration-dependent interaction between high-intensity light and optical refocus in the drive for myopia control Open
PURPOSE To evaluate the duration-dependent and synergetic impact of high-intensity light (HL) and optical refocus (RF) on lens-induced myopia (LIM) development in chickens. METHODS Myopia was induced in one eye in chicks (10 groups, n=126)…
View article: Handheld chromatic pupillometry can reliably detect functional glaucomatous damage in eyes with high myopia
Handheld chromatic pupillometry can reliably detect functional glaucomatous damage in eyes with high myopia Open
Purpose To assess pupillary light responses (PLRs) in eyes with high myopia and evaluate the ability of handheld chromatic pupillometry (HCP) to identify glaucomatous functional loss in eyes with high myopia. Design Cross-sectional study w…
View article: The top 10 most frequently involved genes in hereditary optic neuropathies in 2186 probands
The top 10 most frequently involved genes in hereditary optic neuropathies in 2186 probands Open
Hereditary optic neuropathies are caused by the degeneration of retinal ganglion cells whose axons form the optic nerves, with a consistent genetic heterogeneity. As part of our diagnostic activity, we retrospectively evaluated the combina…
View article: Treatment of nonarteritic anterior ischemic optic neuropathy with an endothelin antagonist: ENDOTHELION (ENDOTHELin antagonist receptor in Ischemic Optic Neuropathy)—a multicentre randomised controlled trial protocol
Treatment of nonarteritic anterior ischemic optic neuropathy with an endothelin antagonist: ENDOTHELION (ENDOTHELin antagonist receptor in Ischemic Optic Neuropathy)—a multicentre randomised controlled trial protocol Open
Background Nonarteritic anterior ischemic optic neuropathy (NAAION) is a major cause of blindness in individuals over 50 years of age, with no available effective treatment. The oral dual endothelin receptor antagonist, bosentan, increases…
View article: Acceptance and Perception of Artificial Intelligence Usability in Eye Care (APPRAISE) for Ophthalmologists: A Multinational Perspective
Acceptance and Perception of Artificial Intelligence Usability in Eye Care (APPRAISE) for Ophthalmologists: A Multinational Perspective Open
Background Many artificial intelligence (AI) studies have focused on development of AI models, novel techniques, and reporting guidelines. However, little is understood about clinicians' perspectives of AI applications in medical fields in…
View article: A deep learning model for detection of Alzheimer's disease based on retinal photographs: a retrospective, multicentre case-control study
A deep learning model for detection of Alzheimer's disease based on retinal photographs: a retrospective, multicentre case-control study Open
BrightFocus Foundation.
View article: Retinal neural dysfunction in diabetes revealed with handheld chromatic pupillometry
Retinal neural dysfunction in diabetes revealed with handheld chromatic pupillometry Open
Background To evaluate the ability of handheld chromatic pupillometry to reveal and localise retinal neural dysfunction in diabetic patients with and without diabetic retinopathy (DR). Methods This cross‐sectional study included 82 diabeti…
View article: Artificial Intelligence Meets Neuro-Ophthalmology
Artificial Intelligence Meets Neuro-Ophthalmology Open
Recent advances in artificial intelligence have provided ophthalmologists with fast, accurate, and automated means for diagnosing and treating ocular conditions, paving the way to a modern and scalable eye care system. Compared to other op…
View article: The Eye Is a Window to Systemic and Neuro-Ophthalmic Diseases
The Eye Is a Window to Systemic and Neuro-Ophthalmic Diseases Open
Ocular involvement is a common and well-known presenting or defining manifestation of many important systemic and neuro-ophthalmic diseases, including multiple vascular, rheumatologic, neoplastic, degenerative, inflammatory, and infectious…