Danping Chen
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Effectiveness and safety of dietary supplements in the adjunctive treatment of psoriasis: a systematic review and network meta-analysis Open
Background Psoriasis, a chronic immune-mediated inflammatory skin disease, significantly impairs quality of life. Conventional treatments often pose safety risks or lack long-term efficacy. Dietary supplements show immunomodulatory and ant…
Signal mining and analysis of influencing factors for adverse events of Nivolumab and Cetuximab in the treatment of head and neck cancer based on the US FAERS database Open
Background No prior research has directly compared adverse drug event (ADE) profiles of Nivolumab and Cetuximab in head and neck cancer (HNC) using the US FDA Adverse Event Reporting System (FAERS). The present study aims to evaluate ADE s…
Impact of Qihuang needle therapy combined with flunarizine hydrochloride for vertigo in vestibular migraine Open
This study suggested that QHN combined with FH might had a potential advantage in improving treatment outcomes and reducing short-term recurrence of vertigo in VM patients.
View article: Connectome-seq: High-throughput Mapping of Neuronal Connectivity at Single-Synapse Resolution via Barcode Sequencing
Connectome-seq: High-throughput Mapping of Neuronal Connectivity at Single-Synapse Resolution via Barcode Sequencing Open
Understanding neuronal connectivity at single-cell resolution remains a fundamental challenge in neuroscience, with current methods particularly limited in mapping long-distance circuits and preserving cell type information. Here we presen…
Key Patent Technology of Litchi Intelligent Sorting System Based on Convolutional Neural Network Open
Background: Litchi is a famous fruit with a large planting area and high output, which has become a pillar industry in many regions. Due to many uncontrollable factors in the production process, such as picking time, fruit size, weather co…
View article: 16S rRNA sequencing-based evaluation of the protective effects of key gut microbiota on inhaled allergen-induced allergic rhinitis
16S rRNA sequencing-based evaluation of the protective effects of key gut microbiota on inhaled allergen-induced allergic rhinitis Open
Introduction Allergic rhinitis (AR) is a common respiratory disorder influenced by various factors in its pathogenesis. Recent studies have begun to emphasize the significant role of gut microbiota in immune modulation and its potential as…
View article: Synthesis, evaluation, and mechanism study of novel benzimidazole acylhydrazone derivatives for antitumor activity
Synthesis, evaluation, and mechanism study of novel benzimidazole acylhydrazone derivatives for antitumor activity Open
This study focuses on the design, synthesis, and evaluation of benzimidazole derivatives for their anti-tumor activity against A549 and PC-3 cells. Initial screening using the MTT assay identified compound 5m as the most potent inhibitor o…
View article: Design, Synthesis and Biological Activity Evaluation of β-Carboline Derivatives Containing Nitrogen Heterocycles
Design, Synthesis and Biological Activity Evaluation of β-Carboline Derivatives Containing Nitrogen Heterocycles Open
A series of β-carboline derivatives containing nitrogen heterocycles were designed and synthesized. All compounds were screened for their antitumor activity against four human tumor cell lines (A549, K562, PC-3, T47D). Notably, compound N-…
View article: Synthesis of novel 4-substituted isatin Schiff base derivatives as potential autophagy inducers and evaluation of their antitumour activity
Synthesis of novel 4-substituted isatin Schiff base derivatives as potential autophagy inducers and evaluation of their antitumour activity Open
Autophagy is a potential target in cancer therapy. In the present study, we designed and synthesized a series of isatin Schiff base derivatives containing thioether structures. After discovering the highly active target compound H13 (IC50 …
<span>MicroRNA</span>‐3061 downregulates the expression of <span>PAX7</span>/<span>Wnt/Ca<sup>2+</sup></span> signalling axis genes to induce premature ovarian failure in mice Open
The in‐depth mechanisms of microRNA regulation of premature ovarian failure (POF) remain unclear. Crispr‐cas9 technology was used to construct transgenic mice. The qPCR and Western blot was used to detect the expression level of genes. H&E…
View article: Single-frequency DBR lasing by integrating FBGs into germanium-free photosensitive highly Yb<sup>3+</sup>-doped silica fibers
Single-frequency DBR lasing by integrating FBGs into germanium-free photosensitive highly Yb<sup>3+</sup>-doped silica fibers Open
Monolithic distributed Bragg reflector (DBR) cavity which directly integrates fiber Bragg gratings (FBGs) into the photosensitive RE-doped fibers is a promising configuration in constructing compact and efficient single frequency fiber las…
Muon beamtest results of high-density glass scintillator tiles Open
To achieve the physics goal of precisely measure the Higgs, Z, W bosons and the top quark, future electron-positron colliders require that their detector system has excellent jet energy resolution. One feasible technical option is the high…
Animation Vr Scene Stitching Modeling Based on Genetic Algorithm Open
The animation scene stitching modeling is further investigated in conjunction with Genetic Algorithms (GA) in order to advance the technology based on the currently used animation scene stitching modeling. To retrieve the low-frequency and…
View article: Design, synthesis, antibacterial evaluation of isopropylamine linked with different substituted phenol and piperazine novel derivatives
Design, synthesis, antibacterial evaluation of isopropylamine linked with different substituted phenol and piperazine novel derivatives Open
BACKGROUND Xanthomonas oryzae pv. oryzae ( Xoo ) is often considered one of the most destructive bacterial pathogens causing bacterial leaf blight (BLB), resulting in significant yield and cost losses in rice. In this study, a series of no…
Oral administration of cranberry-derived exosomes attenuates murine premature ovarian failure in association with changes in the specific gut microbiota and diminution in ovarian granulosa cell PANoptosis Open
We confirmed that oral administration of cranberry-derived exosomes attenuated murine POF by modulating the gut microbiota and decreasing ovarian granulosa cell PANoptosis.
Coordination engineering in Nd3+-doped silica glass for improving repetition rate of 920-nm ultrashort-pulse fiber laser Open
Ultrashort pulses at 920 nm are a highly desired light source in two-photon microscopy for the efficient excitation of green fluorescence protein. Although Nd3 + -doped fibers have been utilized for 920-nm ultrashort pulse generation, the …
View article: Novel 2-Amino-1,4-Naphthoquinone Derivatives Induce A549 Cell Death through Autophagy
Novel 2-Amino-1,4-Naphthoquinone Derivatives Induce A549 Cell Death through Autophagy Open
A series of 1,4-naphthoquinone derivatives containing were synthesized as anti-cancer agents and the crystal structure of compound 5a was confirmed by X-ray diffraction. In addition, the inhibitory activities against four cancer cell lines…
View article: Efficient three-level continuous-wave and GHz passively mode-locked laser by a Nd<sup>3+</sup>-doped silicate glass single mode fiber
Efficient three-level continuous-wave and GHz passively mode-locked laser by a Nd<sup>3+</sup>-doped silicate glass single mode fiber Open
Nd 3+ -doped three-level ( 4 F 3/2 – 4 I 9/2 ) fiber lasers with wavelengths in the range of 850–950 nm are of considerable interest in applications such as bio-medical imaging and blue and ultraviolet laser generation. Although the design…
View article: Discovery of Tryptanthrin and Its Derivatives and Its Activities against NSCLC In Vitro via Both Apoptosis and Autophagy Pathways
Discovery of Tryptanthrin and Its Derivatives and Its Activities against NSCLC In Vitro via Both Apoptosis and Autophagy Pathways Open
In this study, a series of novel tryptanthrin derivatives were synthesized and their inhibitory activities against selected human cancer cell lines, namely, lung (A549), chronic myeloid leukemia (K562), prostate (PC3), and live (HepG2), we…
View article: Synthesis and biological assessment of indole derivatives containing penta-heterocycles scaffold as novel anticancer agents towards A549 and K562 cells
Synthesis and biological assessment of indole derivatives containing penta-heterocycles scaffold as novel anticancer agents towards A549 and K562 cells Open
Herein, a new series of 2-chloro-N-(5-(2-oxoindolin-3-yl)-4H-pyrazol-3-yl) acetamide derivatives containing 1,3,4-thiadiazole (10a–i) and 4H-1,2,4-triazol-4-amine (11a–r) moiety was designed, synthesised as novel anticancer agents. The ant…
Animation VR scene mosaic modeling based on generalized Laplacian equation Open
In order to improve the technology based on the existing animation scene stitching modeling, the animation scene stitching modeling is further studied combined with Laplacian equation. The algorithm uses wavelet transform to decompose the …
Association between depression and malnutrition in pulmonary tuberculosis patients: A cross-sectional study Open
Malnutrition and poor social function are significantly associated with depressive symptoms in PTB patients. A prospective large-scale study is needed to confirm these findings.
View article: Design, Synthesis and Biological Evaluation of Novel Indole-Containing Sorafenib Derivatives
Design, Synthesis and Biological Evaluation of Novel Indole-Containing Sorafenib Derivatives Open
Content1. 1 H NMR, 13 C NMR, and HRMS spectra of target compounds 1-30 2. Inhibition rate of all compounds at 10 μM against four cancer cells 3. Plate clone formation experiment of compound 6 and sorafenib
View article: Highly fluorine and ytterbium doped polarization maintaining large mode area photonic crystal fiber via the sol-gel process
Highly fluorine and ytterbium doped polarization maintaining large mode area photonic crystal fiber via the sol-gel process Open
Highly Yb-doped silica glass with low refractive index for fabrication of Yb-doped large-mode-area photonic crystal fiber (LMA PCF) is in favor of decreasing fiber length and thus increasing the threshold of nonlinear effects in pulse lase…
Thymopentin alleviates premature ovarian failure in mice by activating YY2/Lin28A and inhibiting the expression of let‐7 family microRNAs Open
Objective Thymopentin (5TP) significantly improved typical murine premature ovarian failure (POF) symptoms induced by a high‐fat and high‐sugar (HFHS) diet. However, its effect and mechanism remain unclear. Materials and methods RNA‐Seq wa…
An Analysis of Mainstream Animation Education in Japan and the United States Using Computer 3D Technology Open
As an important part of culture and entertainment, animation is also a form of artistic expression with entertainment and educational functions. The application of computer 3D technology makes the animation more vivid and expressive. This …
View article: Enhanced radiation resistance of ytterbium-doped silica fiber by pretreating on a fiber preform
Enhanced radiation resistance of ytterbium-doped silica fiber by pretreating on a fiber preform Open
We propose a new pretreatment method on fiber preforms by loading deuterium (D 2 ), pre-irradiation, combined with thermal annealing. The effect of the pretreatment condition on the optical loss at 1200 nm and a laser slope efficiency of y…
Polymerization retardation isothermal amplification (PRIA): a strategy enables sensitively quantify genome-wide 5-methylcytosine oxides rapidly on handy instruments with nanoscale sample input Open
The current methods for quantifying genome-wide 5-methylcytosine (5mC) oxides are still scarce, mostly restricted with two limitations: assay sensitivity is seriously compromised with cost, assay time and sample input; epigenetic informati…