Dan Pugh
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View article: Combination Cyclophosphamide and Rituximab to Minimize Glucocorticoid Use in Antineutrophil Cytoplasm Antibody–Associated Vasculitis
Combination Cyclophosphamide and Rituximab to Minimize Glucocorticoid Use in Antineutrophil Cytoplasm Antibody–Associated Vasculitis Open
Early withdrawal of oral glucocorticoid therapy in patients with severe AAV treated with combination cyclophosphamide and rituximab induction immunosuppression is safe and effective and may reduce morbidity, in particular serious infection…
View article: Conquering immunological barrier- part 2: paired kidney exchange transplantation
Conquering immunological barrier- part 2: paired kidney exchange transplantation Open
ABO blood group or human leucocyte antigen (HLA) incompatibility remain major immunological barriers for organ transplantation. One strategic approach to conquer this barrier is desensitize the recipient yet it remains expensive, resource …
View article: 18F-FDG-PET/MR imaging to monitor disease activity in large vessel vasculitis
18F-FDG-PET/MR imaging to monitor disease activity in large vessel vasculitis Open
Disease-monitoring in large vessel vasculitis (LVV) is challenging. Simultaneous 18 F-fluorodeoxyglucose positron emission tomography with magnetic resonance imaging (PET/MRI) provides functional assessment of vascular inflammation alongsi…
View article: OCTolyzer: Fully automatic toolkit for segmentation and feature extracting in optical coherence tomography and scanning laser ophthalmoscopy data
OCTolyzer: Fully automatic toolkit for segmentation and feature extracting in optical coherence tomography and scanning laser ophthalmoscopy data Open
Optical coherence tomography (OCT) and scanning laser ophthalmoscopy (SLO) of the eye has become essential to ophthalmology and the emerging field of oculomics, thus requiring a need for transparent, reproducible, and rapid analysis of thi…
View article: Choroidalyzer: An Open-Source, End-to-End Pipeline for Choroidal Analysis in Optical Coherence Tomography
Choroidalyzer: An Open-Source, End-to-End Pipeline for Choroidal Analysis in Optical Coherence Tomography Open
Choroidalyzer is an open-source, end-to-end pipeline that accurately segments the choroid and reliably extracts thickness, area, and vascular index. Especially choroidal vessel segmentation is a difficult and subjective task, and fully aut…
View article: Domain-specific augmentations with resolution agnostic self-attention mechanism improves choroid segmentation in optical coherence tomography images
Domain-specific augmentations with resolution agnostic self-attention mechanism improves choroid segmentation in optical coherence tomography images Open
The choroid is a key vascular layer of the eye, supplying oxygen to the retinal photoreceptors. Non-invasive enhanced depth imaging optical coherence tomography (EDI-OCT) has recently improved access and visualisation of the choroid, makin…
View article: Choroidal and retinal thinning in chronic kidney disease independently associate with eGFR decline and are modifiable with treatment
Choroidal and retinal thinning in chronic kidney disease independently associate with eGFR decline and are modifiable with treatment Open
In patients with chronic kidney disease (CKD), there is an unmet need for novel biomarkers that reliably track kidney injury, demonstrate treatment-response, and predict outcomes. Here, we investigate the potential of retinal optical coher…
View article: Choroidalyzer: An open-source, end-to-end pipeline for choroidal analysis in optical coherence tomography
Choroidalyzer: An open-source, end-to-end pipeline for choroidal analysis in optical coherence tomography Open
Purpose: To develop Choroidalyzer, an open-source, end-to-end pipeline for segmenting the choroid region, vessels, and fovea, and deriving choroidal thickness, area, and vascular index. Methods: We used 5,600 OCT B-scans (233 subjects, 6 s…
View article: An Open-Source Deep Learning Algorithm for Efficient and Fully Automatic Analysis of the Choroid in Optical Coherence Tomography
An Open-Source Deep Learning Algorithm for Efficient and Fully Automatic Analysis of the Choroid in Optical Coherence Tomography Open
DeepGPET addresses the lack of open-source, fully automatic, and clinically relevant choroid segmentation algorithms, and its subsequent public release will facilitate future choroidal research in both ophthalmology and wider systemic heal…
View article: Evaluation of an Automated Choroid Segmentation Algorithm in a Longitudinal Kidney Donor and Recipient Cohort
Evaluation of an Automated Choroid Segmentation Algorithm in a Longitudinal Kidney Donor and Recipient Cohort Open
We introduce a novel choroid segmentation algorithm that can replace manual grading for studying the choroid in renal disease and other clinical conditions.
View article: An open-source deep learning algorithm for efficient and fully-automatic analysis of the choroid in optical coherence tomography
An open-source deep learning algorithm for efficient and fully-automatic analysis of the choroid in optical coherence tomography Open
Purpose: To develop an open-source, fully-automatic deep learning algorithm, DeepGPET, for choroid region segmentation in optical coherence tomography (OCT) data. Methods: We used a dataset of 715 OCT B-scans (82 subjects, 115 eyes) from 3…
View article: Evaluation of an automated choroid segmentation algorithm in a longitudinal kidney donor and recipient cohort
Evaluation of an automated choroid segmentation algorithm in a longitudinal kidney donor and recipient cohort Open
Purpose: To evaluate the performance of an automated choroid segmentation algorithm in optical coherence tomography (OCT) data using a longitudinal kidney donor and recipient cohort. Methods: We assessed 22 donors and 23 patients requiring…
View article: Endothelin blockade prevents the long-term cardiovascular and renal sequelae of acute kidney injury in mice
Endothelin blockade prevents the long-term cardiovascular and renal sequelae of acute kidney injury in mice Open
Acute kidney injury (AKI) is common and associated with increased risks of cardiovascular and chronic kidney disease. Causative molecular/physiological pathways are poorly defined. There are no therapies to improve long-term outcomes. An a…
View article: Cardiovascular outcomes in patients with chronic kidney disease and COVID-19: a multi-regional data-linkage study
Cardiovascular outcomes in patients with chronic kidney disease and COVID-19: a multi-regional data-linkage study Open
Background Data describing cardiovascular outcomes in patients with coronavirus disease 2019 (COVID-19) and chronic kidney disease (CKD) are lacking. We compared cardiovascular outcomes of patients with and without COVID-19, stratified by …
View article: Utility of interval kidney biopsy in ANCA-associated vasculitis
Utility of interval kidney biopsy in ANCA-associated vasculitis Open
Objectives ANCA-associated vasculitis (AAV) is a rare autoimmune disorder that commonly involves the kidney. Early identification of kidney involvement, assessing treatment-response and predicting outcome are important clinical challenges.…
View article: Interventions for atypical haemolytic uraemic syndrome
Interventions for atypical haemolytic uraemic syndrome Open
When compared with historical data, terminal complement inhibition appears to offer favourable outcomes in patients with aHUS, based upon very low-quality evidence drawn from five single-arm studies. It is unlikely that an RCT will be cond…
View article: Prolonged <scp>SARS‐CoV</scp>‐2 viral shedding in patients with chronic kidney disease
Prolonged <span>SARS‐CoV</span>‐2 viral shedding in patients with chronic kidney disease Open
Recent World Health Organization guidance has aimed to provide pragmatic guidance acknowledging the role of sequential nasopharyngeal swabs taken >24 hours apart for SARS‐CoV‐2 in high‐risk populations. Patients with chronic kidney disease…
View article: Regional variation in the incidence rate and sex ratio of multiple sclerosis in Scotland 2010–2017: findings from the Scottish Multiple Sclerosis Register
Regional variation in the incidence rate and sex ratio of multiple sclerosis in Scotland 2010–2017: findings from the Scottish Multiple Sclerosis Register Open
This study introduces a national incidence register: a valuable research tool and the result of substantial public investment. The wide variation in incidence rates and sex ratios between regions, in a relatively homogenous population, rai…
View article: The Meta-Debrief Club: an effective method for debriefing your debrief
The Meta-Debrief Club: an effective method for debriefing your debrief Open
The application of simulation as an educational tool within medicine is increasing. In immersive simulation, it is widely accepted that the post-scenario debrief is a critical component for learning.1 Effective faculty development is there…