Dan Suan
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Lymphoma driver mutations at the root of somatic evolution of nerve-damaging autoantibodies in myelin associated glycoprotein neuropathy Open
In three MAG neuropathy patients we find evidence that the self-reactive B cells responsible for their disease acquired a classical lymphoma driver somatic mutation early in their clonal expansion.
Can autoimmune disease be cured by deep CD19+ cell depletion? Open
Therapeutic B cell depletion with monoclonal antibodies targeting CD20 forced a rethink about the pathogenic role of B cells and plasma cells in autoimmune diseases; however, it was tempered by frequent clinical relapses or nonresponse to …
View article: A triad of somatic mutagenesis converges in self-reactive B cells to cause a virus-induced autoimmune disease
A triad of somatic mutagenesis converges in self-reactive B cells to cause a virus-induced autoimmune disease Open
The unexplained association between infection and autoimmune disease is strongest for hepatitis C virus-induced cryoglobulinemic vasculitis (HCV-cryovas). To analyze its origins, we traced the evolution of pathogenic rheumatoid factor (RF)…
Clinical correlations of serum anti-dsDNA immunoglobulin subfamilies in patients with systemic lupus erythematosus (SLE) Open
Systemic lupus erythematosus (SLE) is an extremely heterogenous autoimmune disorder. A key biomarker, the double stranded (ds) DNA autoantibody, provides diagnostic specificity for SLE. We analyzed anti-dsDNA by mass spectrometry (MS) to d…
View article: Expanded T cell clones with lymphoma driver somatic mutations in refractory celiac disease
Expanded T cell clones with lymphoma driver somatic mutations in refractory celiac disease Open
Intestinal inflammation continues in a subset of celiac disease (CD) patients despite a gluten-free diet. Here, by applying multiomic single cell analysis to duodenal biopsies, we find low-grade malignancies with lymphoma driver mutations …
Isolation and characterisation of PR3-specific B cells and their immunoglobulin sequences Open
Identifying PR3-specific B cells in the peripheral blood is possible but challenging and those we did identify exhibited features suggesting that PR3-self reactivity may occur early in B-cell development.
Granulomatous mastitis and immunosuppression: Case series at an Australian quaternary referral center Open
Granulomatous mastitis (GM) presents as a tender and firm breast mass that can be accompanied by erythema, pustular drainage, and ulceration. It can be either unilater or bilateral. This condition occurs most commonly in Latina and Asian w…
Isolated anti-Ro52 identifies a severe subset of Sjögren’s syndrome patients Open
Introduction Serum autoantibodies targeting the SSA/Ro proteins are a key component of the classification criteria for the diagnosis of Sjögren’s syndrome (SS). Most patients' serum reacts with both Ro60 and Ro52 proteins. Here we compare …
Chronic spontaneous urticaria following ChAdOx1-S COVID-19 vaccination Open
A 39-year-old Filipino man presented 2 weeks following his second ChAdOx1-S (Oxford/AstraZeneca) coronavirus disease 2019 (COVID-19) vaccination with complaints of widespread urticaria and swelling of his hands.These were spontaneous and o…
Coronary artery vasospasm in a patient with Churg-Strauss syndrome Open
Patients with Churg-Strauss syndrome often suffer from unusual cardiac manifestations and sudden cardiac death. This differs from patients with other autoimmune disorders, who typically present with premature ischaemic heart disease. We re…
View article: A novel cause of chronic viral meningoencephalitis: <scp>C</scp>ache Valley virus
A novel cause of chronic viral meningoencephalitis: <span>C</span>ache Valley virus Open
Objective Immunodeficient patients are particularly vulnerable to neuroinvasive infections that can be challenging to diagnose. Metagenomic next generation sequencing can identify unusual or novel microbes and is therefore well suited for …
View article: Differentiation of germinal center B cells into plasma cells is initiated by high-affinity antigen and completed by Tfh cells
Differentiation of germinal center B cells into plasma cells is initiated by high-affinity antigen and completed by Tfh cells Open
Plasma cells (PCs) derived from germinal centers (GCs) secrete the high-affinity antibodies required for long-term serological immunity. Nevertheless, the process whereby GC B cells differentiate into PCs is uncharacterized, and the mechan…