Dan V. Iosifescu
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View article: Adverse childhood experiences and cardiometabolic risk factors in people with bipolar disorder
Adverse childhood experiences and cardiometabolic risk factors in people with bipolar disorder Open
Bipolar disorder is associated with increased mortality from cardiovascular disease, incidence of Metabolic Syndrome (MetS), and obesity. Adverse childhood experiences (ACEs) may contribute to this increased incidence, but findings have be…
View article: Enhancing sleep, wakefulness, and cognition with transcranial photobiomodulation: a systematic review
Enhancing sleep, wakefulness, and cognition with transcranial photobiomodulation: a systematic review Open
Disruptions in sleep are common across clinical populations, particularly those with neurological and psychiatric disorders, making restorative sleep and sustained wakefulness a public health priority. Sleep is essential for brain function…
View article: Clinical decision support for pharmacologic management of treatment-resistant depression with augmented large language models
Clinical decision support for pharmacologic management of treatment-resistant depression with augmented large language models Open
An augmented language model demonstrated moderate agreement with expert recommendations and avoided contraindicated treatments, suggesting potential as a tool for supporting complex psychopharmacologic decision-making in treatment-resistan…
View article: Personalized non-invasive neuromodulation for sensory-based urge suppression in individuals with OCD: a proof-of-concept investigation
Personalized non-invasive neuromodulation for sensory-based urge suppression in individuals with OCD: a proof-of-concept investigation Open
Obsessive-compulsive disorder (OCD) is chronic and impairing. While OCD often involves fear of harm or bad events, many patients experience “sensory phenomena,” which are aversive sensory experiences that drive repetitive behaviors regardl…
View article: Neurometabolite Changes After Transcranial Photobiomodulation in Major Depressive Disorder: A Randomized Controlled Trial Investigating Dose-Dependent Effects
Neurometabolite Changes After Transcranial Photobiomodulation in Major Depressive Disorder: A Randomized Controlled Trial Investigating Dose-Dependent Effects Open
Background: Transcranial photobiomodulation (t-PBM) is a promising non-invasive therapy for Major Depressive Disorder (MDD). MDD is associated with altered brain metabolism, including changes in N-acetylaspartate (NAA), choline (Cho), and …
View article: 0612 OSA Influences Locus Coeruleus Structural Integrity on 7T MRI in Cognitively Normal Older Adults
0612 OSA Influences Locus Coeruleus Structural Integrity on 7T MRI in Cognitively Normal Older Adults Open
Introduction The locus coeruleus (LC), an important sleep/wake regulating structure and site of early change in neurodegenerative disease, is best measured in humans with ultra-high field 7-Tesla MRI due to its small size. We hypothesized …
View article: Decisional reference point pathology: a mechanism and marker for major depressive disorder in humans
Decisional reference point pathology: a mechanism and marker for major depressive disorder in humans Open
The decisional reference point , the central mechanism of behavioral economics, conditions our evaluations of reinforcers. It determines whether a given event is experienced as positive or negative. Here we show, for the first time, a sign…
View article: Understanding the relationship between childhood abuse and affective symptoms in bipolar disorder: New insights from a network analysis
Understanding the relationship between childhood abuse and affective symptoms in bipolar disorder: New insights from a network analysis Open
The impact of childhood abuse on the presentation of bipolar disorder could be further elucidated by comparing the networks of affective symptoms among individuals with and with no history of childhood abuse. Data from 476 participants in …
View article: Emotion-related impulsivity and suicidal ideation and behavior in schizophrenia spectrum disorder: a pilot fMRI study
Emotion-related impulsivity and suicidal ideation and behavior in schizophrenia spectrum disorder: a pilot fMRI study Open
Introduction Suicidal ideation and behavior (SIB) are serious problems in people with schizophrenia spectrum disorders (SSD). Nevertheless, relatively little is known about the circuitry underlying SIB in SSD. Recently, we showed that elev…
View article: Antidepressant exposure and long‐term dementia risk in a nationwide retrospective study on US veterans with midlife major depressive disorder
Antidepressant exposure and long‐term dementia risk in a nationwide retrospective study on US veterans with midlife major depressive disorder Open
INTRODUCTION The use of antidepressants in major depressive disorder (MDD) has been reported to influence long‐term risk of Alzheimer's disease (AD) and AD‐related dementias (AD/ADRD), but studies are conflicting. METHODS We used inverse p…
View article: Transcranial Photobiomodulation and Chronic Traumatic Brain Injury
Transcranial Photobiomodulation and Chronic Traumatic Brain Injury Open
Traumatic brain injury (TBI) is a common cause of neurologic morbidity for which few effective therapies exist, especially during the chronic stage. A potential therapy for chronic TBI is transcranial photobiomodulation (tPBM). tPBM is a n…
View article: Comparative effectiveness research trial for antidepressant incomplete and non-responders with treatment resistant depression (ASCERTAIN-TRD) a randomized clinical trial
Comparative effectiveness research trial for antidepressant incomplete and non-responders with treatment resistant depression (ASCERTAIN-TRD) a randomized clinical trial Open
Further research is needed to help improve both the standard of care and the outcome for patients with treatment-resistant depression. A particularly critical evidence gap exists with respect to whether pharmacological or non-pharmacologic…
View article: Transcranial photobiomodulation increases intrinsic brain activity within irradiated areas in early Alzheimer's disease: Potential link with cerebral metabolism
Transcranial photobiomodulation increases intrinsic brain activity within irradiated areas in early Alzheimer's disease: Potential link with cerebral metabolism Open
View article: Antidepressant exposure and long‐term dementia risk in a nationwide study on U.S. Veterans with major depressive disorder
Antidepressant exposure and long‐term dementia risk in a nationwide study on U.S. Veterans with major depressive disorder Open
Background Major depressive disorder (MDD) is associated with dementia risk. The use of antidepressants in MDD has been reported to influence long term risk of Alzheimer’s disease and related dementias (ADRD), but studies are conflicting. …
View article: Trajectories of Depressive Individual Symptoms over Time during Transcranial Photobiomodulation
Trajectories of Depressive Individual Symptoms over Time during Transcranial Photobiomodulation Open
Transcranial photobiomodulation (t-PBM) is an innovative, non-invasive treatment for depression. This study aimed to investigate the changes in individual depressive symptoms during t-PBM treatment and identify the symptoms that improved i…
View article: Personality characteristics, not clinical symptoms, are associated with anhedonia in a community sample: A preliminary investigation
Personality characteristics, not clinical symptoms, are associated with anhedonia in a community sample: A preliminary investigation Open
View article: Augmentation of learning in schizophrenia by d-serine and auditory remediation is related to auditory and frontally-generated biomarkers: A randomized, double-blind, placebo-controlled study
Augmentation of learning in schizophrenia by d-serine and auditory remediation is related to auditory and frontally-generated biomarkers: A randomized, double-blind, placebo-controlled study Open
View article: Efficacy of Transcranial Photobiomodulation on Depressive Symptoms: A Meta-Analysis
Efficacy of Transcranial Photobiomodulation on Depressive Symptoms: A Meta-Analysis Open
Background: Transcranial photobiomodulation (tPBM) is a novel, noninvasive, device-based intervention, which has been tested as a possible treatment for various neurological and psychiatric conditions. Recently, it has been i…
View article: The Impact of Post-Stroke Depressive Symptoms on Cognitive Performance in Women and in Men: A 4 Month Prospective Study
The Impact of Post-Stroke Depressive Symptoms on Cognitive Performance in Women and in Men: A 4 Month Prospective Study Open
Background: Depressive symptoms have been associated with cognitive impairment after stroke, and women may be specifically affected. Objective: The aim of this study was to investigate gender-specific characteristics in the relationship be…
View article: Protocol Report on the Transcranial Photobiomodulation for Alzheimer’s Disease (TRAP-AD) Study
Protocol Report on the Transcranial Photobiomodulation for Alzheimer’s Disease (TRAP-AD) Study Open
Background: Alzheimer’s disease’s (AD) prevalence is projected to increase as the population ages and current treatments are minimally effective. Transcranial photobiomodulation (t-PBM) with near-infrared (NIR) light penetrates into the ce…
View article: Comparison of Adiponectin Levels in Anorexia Nervosa, Bulimia Nervosa, Binge-Eating Disorder, Obesity, Constitutional Thinness, and Healthy Controls: A Network Meta-Analysis
Comparison of Adiponectin Levels in Anorexia Nervosa, Bulimia Nervosa, Binge-Eating Disorder, Obesity, Constitutional Thinness, and Healthy Controls: A Network Meta-Analysis Open
Adiponectin is a protein hormone that is produced and secreted primarily by adipose tissue. The levels of adiponectin in those with eating disorders, obesity, and healthy controls have been extensively studied. However, the general picture…
View article: (039) Social Support Significantly Mediates the Relationship Between Gender Role Nonconformity and Sexual Dysfunction
(039) Social Support Significantly Mediates the Relationship Between Gender Role Nonconformity and Sexual Dysfunction Open
Introduction Uncertainty remains about the psychological and sexual implications of gender role nonconformity (GRNC), generally defined as men endorsing or performing femininity, and women endorsing or performing masculinity. Previous stud…
View article: Dose-Dependent Augmentation of Neuroplasticity-Based Auditory Learning in Schizophrenia: A Double-Blind, Placebo-Controlled, Randomized, Target Engagement Clinical Trial of the NMDA Glutamate Receptor Agonist d-serine
Dose-Dependent Augmentation of Neuroplasticity-Based Auditory Learning in Schizophrenia: A Double-Blind, Placebo-Controlled, Randomized, Target Engagement Clinical Trial of the NMDA Glutamate Receptor Agonist d-serine Open
View article: Grant Report on the Transcranial near Infrared Radiation and Cerebral Blood Flow in Depression (TRIADE) Study
Grant Report on the Transcranial near Infrared Radiation and Cerebral Blood Flow in Depression (TRIADE) Study Open
We report on the rationale and design of an ongoing National Institute of Mental Health (NIMH) sponsored R61-R33 project in major depressive disorder (MDD). Current treatments for MDD have significant limitations in efficacy and side effec…
View article: Transcranial photobiomodulation in major depressive disorder: dose-dependent effects on depression and anxiety scores
Transcranial photobiomodulation in major depressive disorder: dose-dependent effects on depression and anxiety scores Open
View article: The Association of Life Events Outside the Workplace and Burnout: A Cross-Sectional Study on Nursing Assistants
The Association of Life Events Outside the Workplace and Burnout: A Cross-Sectional Study on Nursing Assistants Open
Background: Burnout, by definition, is related to adverse chronic workplace stressors. Life events outside the workplace have been associated with an increased risk of psychiatric morbidity. However, it is unknown whether life events outsi…
View article: Tolerability and Safety of Transcranial Photobiomodulation for Mood and Anxiety Disorders
Tolerability and Safety of Transcranial Photobiomodulation for Mood and Anxiety Disorders Open
Introduction: Mood and anxiety disorders are a prevalent and significant leading cause of years lived with a disability worldwide. Existing antidepressants drugs are only partially effective, having burdensome side effects. One-third of pa…
View article: Efficacy and Safety of AXS-05 (Dextromethorphan-Bupropion) in Patients With Major Depressive Disorder
Efficacy and Safety of AXS-05 (Dextromethorphan-Bupropion) in Patients With Major Depressive Disorder Open
Trial Registration: ClinicalTrials.gov Identifier: NCT04019704.
View article: Childhood trauma and treatment outcomes during mood‐stabilising treatment with lithium or quetiapine among outpatients with bipolar disorder
Childhood trauma and treatment outcomes during mood‐stabilising treatment with lithium or quetiapine among outpatients with bipolar disorder Open
Background Childhood trauma affects the course of mood disorders. Researchers are now considering childhood trauma as an influential factor in the treatment of mood disorders. However, the role of childhood trauma in the treatment of bipol…
View article: Relationships between interoceptive sensibility and resting-state functional connectivity of the insula in obsessive–compulsive disorder
Relationships between interoceptive sensibility and resting-state functional connectivity of the insula in obsessive–compulsive disorder Open
Patients with obsessive–compulsive disorder (OCD) exhibit abnormality in their subjective perception of internal sensation, a process known as interoceptive sensibility (IS), as well as altered functioning of the insula, a key neural struc…