Dan V. Nicolau
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View article: Hierarchical Structure of the Program Used by Filamentous Fungi to Navigate in Confining Microenvironments
Hierarchical Structure of the Program Used by Filamentous Fungi to Navigate in Confining Microenvironments Open
The spatial navigation of filamentous fungi was compared for three species, namely Pycnoporus cinnabarinus, Neurospora crassa wild type and ro-1 mutant, and Armillaria mellea, in microfluidic structures. The analysis of the navigation of t…
View article: Understanding the Impact of Synthetic Hematocrit Levels and Biomimetic Channel Widths on Bubble Parameters in Vascular Systems on a Chip
Understanding the Impact of Synthetic Hematocrit Levels and Biomimetic Channel Widths on Bubble Parameters in Vascular Systems on a Chip Open
Gas embolism is a rare but life-threatening process characterized by the presence of gas bubbles in the venous or arterial systems. These bubbles, if sufficiently large or numerous, can block the delivery of oxygen to critical organs, in p…
View article: AI-Driven Neuro-Monitoring: Advancing Schizophrenia Detection and Management Through Deep Learning and EEG Analysis
AI-Driven Neuro-Monitoring: Advancing Schizophrenia Detection and Management Through Deep Learning and EEG Analysis Open
Schizophrenia is a complex neuropsychiatric disorder characterized by disruptions in brain connectivity and cognitive functioning. Continuous monitoring of neural activity is essential, as it allows for the detection of subtle changes in b…
View article: IUCN Red List of Ecosystems, Mangroves of the Western Indian Ocean
IUCN Red List of Ecosystems, Mangroves of the Western Indian Ocean Open
‘Mangroves of the Western Indian Ocean’ is a regional ecosystem subgroup (level 4 unit of the IUCN Global Ecosystem Typology). This province spans 10 countries and includes the following marine ecoregions: Cargados Carajos/Tromelin Island,…
View article: Immobilization of multiple proteins in polymer micro-structures fabricated via laser ablation
Immobilization of multiple proteins in polymer micro-structures fabricated via laser ablation Open
Investigation of protein-polymeric surface interaction requires reliable practical techniques for evaluation of the efficiency of protein immobilization. In this study the efficiency of protein immobilization was evaluated using three diff…
View article: AFM analysis of the polymer micro-structures used for novel multi-analyte protein micro-assay
AFM analysis of the polymer micro-structures used for novel multi-analyte protein micro-assay Open
We recently described a technique to fabricate shallow (< 50 nm) microstructures on PMMA surface for use in multianalyte protein micro-assay based on the ablation of a top thin gold layer using pulsed nitrogen laser (337 nm). In the presen…
View article: ATP level variations in heterotrophic bacteria during attachment on hydrophilic and hydrophobic surfaces
ATP level variations in heterotrophic bacteria during attachment on hydrophilic and hydrophobic surfaces Open
A survey of the extracellular ATP levels of 86 heterotrophic bacteria showed that gram-negative bacteria of the genera Sulfitobacter, Staleya, and Marinobacter secreted elevated amounts of extracellular ATP, ranging from 6.0 to 9.8 pM ATP/…
View article: Hydrophobic Recovery of PDMS Surfaces in Contact with Hydrophilic Entities: Relevance to Biomedical Devices
Hydrophobic Recovery of PDMS Surfaces in Contact with Hydrophilic Entities: Relevance to Biomedical Devices Open
Polydimethylsiloxane (PDMS), a silicone elastomer, is increasingly being used in health and biomedical fields due to its excellent optical and mechanical properties. Its biocompatibility and resistance to biodegradation led to various appl…
View article: <em></em> <i>In Vitro</i> Investigation of Gas Embolism in Microfluidic Networks Mimicking Microvasculature
<em></em> <i>In Vitro</i> Investigation of Gas Embolism in Microfluidic Networks Mimicking Microvasculature Open
Gas embolism is a medical condition leading to the blockage of blood flow in the microvasculature by gas bubbles. While reported as rare, gas embolism often has devastating, fatal physiological consequences. Despite this acute importance, …
View article: As good as it gets: a scaling comparison of DNA computing, network biocomputing, and electronic computing approaches to an NP-complete problem
As good as it gets: a scaling comparison of DNA computing, network biocomputing, and electronic computing approaches to an NP-complete problem Open
All known algorithms to solve nondeterministic polynomial (NP) complete problems, relevant to many real-life applications, require the exploration of a space of potential solutions, which grows exponentially with the size of the problem. S…
View article: Design and fabrication of networks for bacterial computing
Design and fabrication of networks for bacterial computing Open
Non-deterministic polynomial (NP-) complete problems, whose number of possible solutions grows exponentially with the number of variables, require by necessity massively parallel computation. Because sequential computers, such as solid sta…
View article: Modeling Credit Risk: A Category Theory Perspective
Modeling Credit Risk: A Category Theory Perspective Open
This paper proposes a conceptual modeling framework based on category theory that serves as a tool to study common structures underlying diverse approaches to modeling credit default that at first sight may appear to have nothing in common…
View article: Patterns of bacterial motility in microfluidics-confining environments
Patterns of bacterial motility in microfluidics-confining environments Open
Significance Understanding bacterial movement is crucial for health, agriculture, environment, and industry. Studying the motility of five bacterial species in microfluidic environments showed that bacterial motility behavior is the result…
View article: Epigenome erosion drives neural crest-like phenotypic mimicry in triple-negative breast cancer and other SOX10+ malignancies
Epigenome erosion drives neural crest-like phenotypic mimicry in triple-negative breast cancer and other SOX10+ malignancies Open
A bstract Background Intratumoural heterogeneity is a poor prognostic feature in triple-negative breast cancer (TNBC) and other high-grade malignancies. It is caused by genomic instability and phenotypic plasticity, but how these features …
View article: Lensless, reflection-based dark-field microscopy (RDFM) on a CMOS chip
Lensless, reflection-based dark-field microscopy (RDFM) on a CMOS chip Open
We present for the first time a lens-free, oblique illumination imaging platform for on-sensor dark- field microscopy and shadow-based 3D object measurements. It consists of an LED point source that illuminates a 5-megapixel, 1.4 µm pixel …
View article: Correction to ‘Something has to give: scaling combinatorial computing by biological agents exploring physical networks encoding NP-complete problems’
Correction to ‘Something has to give: scaling combinatorial computing by biological agents exploring physical networks encoding NP-complete problems’ Open
[This corrects the article DOI: 10.1098/rsfs.2018.0034.].
View article: Intracellular mechanisms of fungal space searching in microenvironments
Intracellular mechanisms of fungal space searching in microenvironments Open
Significance Many filamentous fungi colonizing animal or plant tissue, waste matter, or soil must find optimal paths through the constraining geometries of their microenvironment. Imaging of live fungal growth in custom-built microfluidics…
View article: Towards Cytoskeleton Computers. A Proposal
Towards Cytoskeleton Computers. A Proposal Open
Actin and tubulin are key structural elements of Eukaryotes' cytoskeleton. The networks of actin filaments and tubulin microtubules are substrates for cells' motility and mechanics, intra-cellular transport and cell-level learning. Ideas o…
View article: Dual-phone illumination-imaging system for high resolution and large field of view multi-modal microscopy
Dual-phone illumination-imaging system for high resolution and large field of view multi-modal microscopy Open
Bright-field, dark-field, Rheinberg, fluorescence microscopy on a mobile phone with phone screen illumination.
View article: Something has to give: scaling combinatorial computing by biological agents exploring physical networks encoding NP-complete problems
Something has to give: scaling combinatorial computing by biological agents exploring physical networks encoding NP-complete problems Open
On-chip network-based computation, using biological agents, is a new hardware-embedded approach which attempts to find solutions to combinatorial problems, in principle, in a shorter time than the fast, but sequential electronic computers.…
View article: Towards Cytoskeleton Computers. A proposal
Towards Cytoskeleton Computers. A proposal Open
We propose a road-map to experimental implementation of cytoskeleton-based computing devices. An overall concept is described in the following. Collision-based cytoskeleton computers implement logical gates via interactions between travell…
View article: Intracellular mechanisms of fungal space searching in microenvironments
Intracellular mechanisms of fungal space searching in microenvironments Open
The underlying intracellular mechanisms involved in the fungal growth received considerable attention, but the experimental and theoretical work did not take into account the modulation of these processes by constraining microenvironments …
View article: Front Matter: Volume 10068
Front Matter: Volume 10068 Open
View article: Polymer surface properties control the function of heavy meromyosin in dynamic nanodevices
Polymer surface properties control the function of heavy meromyosin in dynamic nanodevices Open
View article: Front Matter: Volume 9721
Front Matter: Volume 9721 Open
View article: Front Matter: Volume 9711
Front Matter: Volume 9711 Open
View article: Parallel computation with molecular-motor-propelled agents in nanofabricated networks
Parallel computation with molecular-motor-propelled agents in nanofabricated networks Open
Significance Electronic computers are extremely powerful at performing a high number of operations at very high speeds, sequentially. However, they struggle with combinatorial tasks that can be solved faster if many operations are performe…
View article: Protein patterning by microcontact printing using pyramidal PDMS stamps
Protein patterning by microcontact printing using pyramidal PDMS stamps Open
Micro-contact printing, μCP, is a well-established soft-lithography technique for printing biomolecules. μCP uses stamps made of Poly(dimethylsiloxane), PDMS, made by replicating a microstructured silicon master fabricated by semiconductor…
View article: Space Searching Algorithms Used by Fungi
Space Searching Algorithms Used by Fungi Open
Experimental studies have shown that fungi use a natural program for searching the space available in micro-confined networks, e.g., mazes. This natural program, which comprises two subroutines, i.e., collision-induced branching and direct…
View article: Space Searching Algorithms Used by Fungi.
Space Searching Algorithms Used by Fungi. Open
Experimental studies have shown that fungi use a natural program for searching the space available in micro-confined networks, e.g., mazes. This natural program, which comprises two subroutines, i.e., collision-induced branching and direct…