Linda L. D. Zhong
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View article: Application of productive failure theory combined with debriefing teaching model in peripherally inserted central catheter skill training for oncology specialist nurses
Application of productive failure theory combined with debriefing teaching model in peripherally inserted central catheter skill training for oncology specialist nurses Open
View article: Electro-acupuncture for irritable bowel syndrome with constipation: study protocol of a pilot, randomized, double-blinded, sham-controlled trial
Electro-acupuncture for irritable bowel syndrome with constipation: study protocol of a pilot, randomized, double-blinded, sham-controlled trial Open
Introduction Irritable bowel syndrome with constipation (IBS-C) is a common functional gastrointestinal disorder characterized by constipation, abdominal discomfort, and a substantial impact on patients’ quality of life. While acupuncture …
View article: Electro-acupuncture for long COVID neuropsychiatric symptoms: study protocol for a prospective, randomized sham-controlled, patient-assessor-blinded clinical trial
Electro-acupuncture for long COVID neuropsychiatric symptoms: study protocol for a prospective, randomized sham-controlled, patient-assessor-blinded clinical trial Open
Introduction Patients recovering from long COVID often endure a spectrum of neuropsychiatric symptoms, including cognitive impairment, memory deficits, mood disturbances and sleep disorders, that significantly impact their quality of life.…
View article: The Rome consensus: good clinical trials for traditional medicine
The Rome consensus: good clinical trials for traditional medicine Open
View article: Progressive Increase in Small Intestinal Bacterial Overgrowth Risk Following COVID-19 Infection: A Global Population-Based Study
Progressive Increase in Small Intestinal Bacterial Overgrowth Risk Following COVID-19 Infection: A Global Population-Based Study Open
Background/Objectives: Coronavirus disease 2019 (COVID-19) is associated with gastrointestinal (GI) symptoms. Small intestinal bacterial overgrowth (SIBO) is emerging as a significant GI sequela post-COVID-19 infection. This study aimed to…
View article: Integrating traditional Chinese medicine into disease management in Singapore
Integrating traditional Chinese medicine into disease management in Singapore Open
Introduction: While traditional Chinese medicine (TCM) has a long history and continues to be widely practised, its overall clinical efficacy according to conventional scientific standards remains the topic of ongoing research and explorat…
View article: The Rome consensus: Good clinical trials for traditional medicine
The Rome consensus: Good clinical trials for traditional medicine Open
View article: An Interpretable AI framework Quantifying Traditional Chinese Medicine Principles Towards Enhancing and Integrating with Modern Biomedicine
An Interpretable AI framework Quantifying Traditional Chinese Medicine Principles Towards Enhancing and Integrating with Modern Biomedicine Open
Traditional Chinese Medicine diagnosis and treatment principles, established through centuries of trial-and-error clinical practice, directly maps patient-specific symptom patterns to personalised herbal therapies. These empirical holistic…
View article: PIM1 Attenuates Innate Immunity to Foster Coronavirus Replication through Ubiquitin Ligase β‐TrCP‐Mediated IFNAR1 Degradation
PIM1 Attenuates Innate Immunity to Foster Coronavirus Replication through Ubiquitin Ligase β‐TrCP‐Mediated IFNAR1 Degradation Open
Virus infection stimulates proto‐oncoprotein PIM1 kinase expression, but its importance and the biological functions of this process are poorly understood. Herein, PIM1 promotes IFNAR1 degradation to attenuate cellular innate immunity duri…
View article: Butyrate-producing commensal bacteria mediates the efficacy of herbal medicine JCM-16021 on abdominal pain in diarrhea-predominant irritable bowel syndrome: a randomized clinical trial
Butyrate-producing commensal bacteria mediates the efficacy of herbal medicine JCM-16021 on abdominal pain in diarrhea-predominant irritable bowel syndrome: a randomized clinical trial Open
gov no: NCT03457324.
View article: Scalp acupuncture for patients with primary depressive symptoms: a pragmatic, randomized controlled trial
Scalp acupuncture for patients with primary depressive symptoms: a pragmatic, randomized controlled trial Open
View article: Effect of interventions for the management of sleep disturbances in patients with long COVID: a systematic review and meta-analysis of randomized controlled trials
Effect of interventions for the management of sleep disturbances in patients with long COVID: a systematic review and meta-analysis of randomized controlled trials Open
Goh DY, Lam WC, Zhong LLD. Effect of interventions for the management of sleep disturbances in patients with long COVID: a systematic review and meta-analysis of randomized controlled trials. J Clin Sleep Med. 2025;21(11):1993-2005.
View article: Artificial Intelligence in the Editorial and Peer Review Process: A Protocol for a Cross-Sectional Survey of Traditional, Complementary, and Integrative Medicine Journal Editors’ Perceptions
Artificial Intelligence in the Editorial and Peer Review Process: A Protocol for a Cross-Sectional Survey of Traditional, Complementary, and Integrative Medicine Journal Editors’ Perceptions Open
This research protocol outlines a cross-sectional survey study, aimed at editors from traditional, complementary, and integrative medicine (TCIM) journals, regarding their perceptions of the use of artificial intelligence (AI) in the edito…
View article: Establishing expert consensus on Chinese herbal medicine for rheumatoid arthritis management in Singapore
Establishing expert consensus on Chinese herbal medicine for rheumatoid arthritis management in Singapore Open
Objective: To establish consensus on Chinese Herbal Medicine (CHM) for rheumatoid arthritis (RA) among 21 Singaporean experts, this study addressed the lack of CHM clinical practice guidelines (CPGs) in Singapore. Despite advancements in R…
View article: Quantitative evaluation of hospital workplace violence prevention and control policies in China: based on PMC index model
Quantitative evaluation of hospital workplace violence prevention and control policies in China: based on PMC index model Open
View article: Multimodal rehabilitation to improve quality of life and fatigue after radiotherapy in esophageal cancer patients: a randomized trial
Multimodal rehabilitation to improve quality of life and fatigue after radiotherapy in esophageal cancer patients: a randomized trial Open
Purpose To compare the effects of nurse-led multimodal rehabilitation with conventional rehabilitation on quality of life and physical recovery during adjuvant radiotherapy for postoperative esophageal cancer. Methods Seventy participants …
View article: Bias in student evaluations of teaching in undergraduate medical education: a qualitative study from a medical school in Northern China
Bias in student evaluations of teaching in undergraduate medical education: a qualitative study from a medical school in Northern China Open
Biases in medical students' teaching evaluations are multifaceted and can primarily be attributed to teacher-student interpersonal relationships, student perceptions, and systemic issues within the evaluation process. To enhance the object…
View article: Accelerated acupuncture therapy for patients with major depressive symptoms: a single blind, randomized wait-list controlled trial
Accelerated acupuncture therapy for patients with major depressive symptoms: a single blind, randomized wait-list controlled trial Open
Aim: To test the effectiveness of an accelerated acupuncture treatment as an augmentation therapy for patients with primary diagnosis of major depressive symptoms. Methods: Recruited patients were 1:1 randomly assigned to receive either tr…
View article: ILF2 blockade suppresses helicase-mediated R-loop resolution to induce lethality in homologous recombination-deficient cancers
ILF2 blockade suppresses helicase-mediated R-loop resolution to induce lethality in homologous recombination-deficient cancers Open
SUMMARY Hidden beneath the layer of tumor malignancy lies unchecked proliferation driven by hyperactive transcription, which fosters the formation of RNA:DNA hybrids. These structural intermediates precipitate collisions between the transc…
View article: Developing a transparent reporting tool for AI-based diagnostic prediction models of disease and syndrome in Chinese medicine: a Delphi protocol
Developing a transparent reporting tool for AI-based diagnostic prediction models of disease and syndrome in Chinese medicine: a Delphi protocol Open
Introduction The application of artificial intelligence in diagnostic prediction models for diseases and syndromes in Chinese Medicine (CM) has been rapidly expanding, accompanied by a significant increase in related research publications.…
View article: CDSS score is favorable to ISTH score on outcomes for disseminated intravascular coagulation in patients with liver transplantation: a retrospective cohort study
CDSS score is favorable to ISTH score on outcomes for disseminated intravascular coagulation in patients with liver transplantation: a retrospective cohort study Open
Background Limited data are available regarding disseminated intravascular coagulation (DIC) scores after liver transplantation (LT). As Chinese DIC Scoring System (CDSS) is widely accepted for assessing coagulation in China, this study wa…
View article: Using Integrative Therapies to Improve Patient‐Reported Outcomes in Breast Cancer Survivors: A Living Evidence‐Based Clinical Practice Guideline
Using Integrative Therapies to Improve Patient‐Reported Outcomes in Breast Cancer Survivors: A Living Evidence‐Based Clinical Practice Guideline Open
Aim Breast cancer imposes a serious disease and economic burden on patients. This guideline aims to develop a living evidence‐based clinical practice recommendations to guide the use of integrative therapies for the improvement of patient‐…
View article: Risk of intraocular pressure elevation associated with triamcinolone acetonide administration via different routes in macular edema: a systematic review and network meta-analysis of randomized controlled trials
Risk of intraocular pressure elevation associated with triamcinolone acetonide administration via different routes in macular edema: a systematic review and network meta-analysis of randomized controlled trials Open
View article: Genetic parameters of vulva traits and impact of vulva scores on gilts culling in Large White pigs
Genetic parameters of vulva traits and impact of vulva scores on gilts culling in Large White pigs Open
Vulva morphologies represent significant traits in pig production. Recent studies suggest that vulva size can be predictive of the reproductive performance of gilts. This study aimed to analyse the genetic parameters of vulva traits, inclu…
View article: Efficacy of different routes of triamcinolone acetonide administration on macular edema: A systematic review and network meta-analysis
Efficacy of different routes of triamcinolone acetonide administration on macular edema: A systematic review and network meta-analysis Open
There is different administration routes of triamcinolone acetonide (TA) administration for macular edema, but the efficacy ranking remains unclear. The purpose of this study is to assess the efficacy of different administration routes of …
View article: Scalp acupuncture for patients with primary depressive symptoms: a pragmatic, randomized controlled trial
Scalp acupuncture for patients with primary depressive symptoms: a pragmatic, randomized controlled trial Open
View article: Treating Acute Low Back Pain with Acupuncture – an Rct Comparing The Effectiveness between Distal Acupoints and Local Acupoints
Treating Acute Low Back Pain with Acupuncture – an Rct Comparing The Effectiveness between Distal Acupoints and Local Acupoints Open
View article: Multiomics Integration and Machine Learning Reveal Colony Stimulating Factor 3 Receptor as a Key Gene and Therapeutic Target in Crohn’s Disease
Multiomics Integration and Machine Learning Reveal Colony Stimulating Factor 3 Receptor as a Key Gene and Therapeutic Target in Crohn’s Disease Open
Crohn’s disease (CD) is a chronic inflammatory disease characterized by complex immune dysregulation in which the identification of key molecular drivers is critical for the advancement of diagnostic and therapeutic approaches. In this stu…
View article: Managing Type 2 Diabetes Mellitus via the Regulation of Gut Microbiota: A Chinese Medicine Perspective
Managing Type 2 Diabetes Mellitus via the Regulation of Gut Microbiota: A Chinese Medicine Perspective Open
Background: Type 2 Diabetes Mellitus (T2DM) is a metabolic disorder characterized by insulin resistance and inadequate insulin production. Given the increased frequency of T2DM and the health issues it can cause, there is an increasing nee…
View article: Automatic Algorithm Applied for Calculating Thermal Conductivity by Transient Plane Source Method
Automatic Algorithm Applied for Calculating Thermal Conductivity by Transient Plane Source Method Open
As a thermal conductivity measurement method, Transient Plane Source (TPS) method has gained much popularity because of its broad applicability, short measurement times, high precision and simple sample preparation. However, the accuracy o…