Dana A. Page
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View article: Structural basis for the rescue of hyperexcitable cells by the amyotrophic lateral sclerosis drug Riluzole
Structural basis for the rescue of hyperexcitable cells by the amyotrophic lateral sclerosis drug Riluzole Open
Neuronal hyperexcitability is a key element of many neurodegenerative disorders including the motor neuron disease Amyotrophic Lateral Sclerosis (ALS), where it occurs associated with elevated late sodium current (I NaL ). I NaL results fr…
View article: Cannabidiol potentiates hyperpolarization-activated cyclic nucleotide–gated (HCN4) channels
Cannabidiol potentiates hyperpolarization-activated cyclic nucleotide–gated (HCN4) channels Open
Cannabidiol (CBD), the main non-psychotropic phytocannabinoid produced by the Cannabis sativa plant, blocks a variety of cardiac ion channels. We aimed to identify whether CBD regulated the cardiac pacemaker channel or the hyperpolarizatio…
View article: Abstract 2067 Tuning HCN channels by interaction of the cytoplasmic C-linker with the transmembrane region
Abstract 2067 Tuning HCN channels by interaction of the cytoplasmic C-linker with the transmembrane region Open
Hyperpolarization-activated cation (HCN) channels regulate oscillatory electrical activity in the brain and heart. Voltage-gating mediated by their transmembrane (TM) region is inhibited by a cytoplasmic cyclic nucleotide-binding (CNB) fol…
View article: Multifocal Ectopic Purkinje Premature Contractions due to neutralization of an<i>SCN5A</i>negative charge: structural insights into the gating pore hypothesis
Multifocal Ectopic Purkinje Premature Contractions due to neutralization of an<i>SCN5A</i>negative charge: structural insights into the gating pore hypothesis Open
Background We identified a novel SCN5A variant, E171Q, in a neonate with very frequent ectopy and reduced ejection fraction which normalized after arrhythmia suppression by flecainide. This clinical picture is consistent with multifocal ec…
View article: ARumenamides: A novel class of potential antiarrhythmic compounds
ARumenamides: A novel class of potential antiarrhythmic compounds Open
Background: Most therapeutics targeting cardiac voltage-gated sodium channels (Nav1.5) attenuate the sodium current (I Na ) conducted through the pore of the protein. Whereas these drugs may be beneficial for disease states associated with…
View article: Cytoplasmic Autoinhibition in HCN Channels is Regulated by the Transmembrane Region
Cytoplasmic Autoinhibition in HCN Channels is Regulated by the Transmembrane Region Open
Hyperpolarization-activated cation-nonselective (HCN) channels regulate electrical activity in the brain and heart in a cAMP-dependent manner. The voltage-gating of these channels is mediated by a transmembrane (TM) region but is additiona…
View article: HCN channel regulation by the cAMP-binding fold is facilitated by interdomain interactions
HCN channel regulation by the cAMP-binding fold is facilitated by interdomain interactions Open
Hyperpolarization and Cyclic Nucleotide-gated (HCN) channels regulate electrical activity in rhythmically firing cells of the brain and heart. Their voltage-gating is mediated by a transmembrane (TM) region and also by direct binding of cA…
View article: Role of Interactions between Transmembrane and C-Terminal Regions in Voltage-Dependent Activation of HCN4 Channels
Role of Interactions between Transmembrane and C-Terminal Regions in Voltage-Dependent Activation of HCN4 Channels Open
View article: A Charged Residue in the HCN Channel C-Linker Stabilizes the Open State
A Charged Residue in the HCN Channel C-Linker Stabilizes the Open State Open