Dana Bohan
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View article: Ebola virus’ hidden target: virus transmission to and infection of skin
Ebola virus’ hidden target: virus transmission to and infection of skin Open
Ebola virus (EBOV), the causative agent of Ebola virus disease, remains one of the World Health Organization’s top 10 threats to global health. Infectious EBOV virions can be found on the surface of skin late in infection and may be transm…
View article: Ebola’s Hidden Target: Virus Transmission to and Accumulation within Skin
Ebola’s Hidden Target: Virus Transmission to and Accumulation within Skin Open
Ebola virus (EBOV), the causative agent of Ebola virus disease (EVD), remains one of WHO’s top ten threats to global health. Infectious EBOV virions can be found on the surface of skin late during systemic infection and passed from the dec…
View article: High resistance barrier and prophylactic protection in preclinical models of SARS-CoV-2 with two siRNA combination
High resistance barrier and prophylactic protection in preclinical models of SARS-CoV-2 with two siRNA combination Open
RNA interference is a natural antiviral mechanism that could be harnessed to combat SARS-CoV-2 infection by targeting and destroying the viral RNA. We identified potent lipophilic small interfering RNA (siRNA) conjugates targeting highly c…
View article: Neutralization, effector function and immune imprinting of Omicron variants
Neutralization, effector function and immune imprinting of Omicron variants Open
Currently circulating SARS-CoV-2 variants have acquired convergent mutations at hot spots in the receptor-binding domain 1 (RBD) of the spike protein. The effects of these mutations on viral infection and transmission and the efficacy of v…
View article: Therapeutic and vaccine-induced cross-reactive antibodies with effector function against emerging Omicron variants
Therapeutic and vaccine-induced cross-reactive antibodies with effector function against emerging Omicron variants Open
Currently circulating SARS-CoV-2 variants acquired convergent mutations at receptor-binding domain (RBD) hot spots 1 . Their impact on viral infection, transmission, and efficacy of vaccines and therapeutics remains poorly understood. Here…
View article: Epitranscriptomic <i>N</i> <sup>6</sup> -Methyladenosine Profile of SARS-CoV-2-Infected Human Lung Epithelial Cells
Epitranscriptomic <i>N</i> <sup>6</sup> -Methyladenosine Profile of SARS-CoV-2-Infected Human Lung Epithelial Cells Open
Posttranscriptional modification of viral and cellular RNA by N 6 -methyladenosine (m 6 A) plays an important role in regulating the replication of many viruses and the cellular immune response to infection. We therefore sought to define t…
View article: Epitranscriptomic <i>N</i> <sup>6</sup> -methyladenosine profile of SARS-CoV-2-infected human lung epithelial cells
Epitranscriptomic <i>N</i> <sup>6</sup> -methyladenosine profile of SARS-CoV-2-infected human lung epithelial cells Open
N 6 -methyladenosine (m 6 A) is a dynamic post-transcriptional RNA modification that plays an important role in determining transcript fate. Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) has caused the global pandemi…
Human Organotypic Airway and Lung Organoid Cells of Bronchiolar and Alveolar Differentiation Are Permissive to Infection by Influenza and SARS-CoV-2 Respiratory Virus Open
The ongoing coronavirus disease 2019 (COVID-19) pandemic has led to the initiation of unprecedented research efforts to understand the pathogenesis mediated by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). More knowledge is…
Limited Variation between SARS-CoV-2-Infected Individuals in Domain Specificity and Relative Potency of the Antibody Response against the Spike Glycoprotein Open
Infection by SARS-CoV-2 elicits antibodies against various domains of the spike protein, including the RBD and NTD of subunit S1 and against subunit S2. The antibody responses of different infected individuals exhibit different efficacies …
Phosphatidylserine receptors enhance SARS-CoV-2 infection Open
Phosphatidylserine (PS) receptors enhance infection of many enveloped viruses through virion-associated PS binding that is termed apoptotic mimicry. Here we show that this broadly shared uptake mechanism is utilized by SARS-CoV-2 in cells …
Limited variation between SARS-CoV-2-infected individuals in domain specificity and relative potency of the antibody response against the spike glycoprotein Open
The spike protein of SARS-CoV-2 is arranged as a trimer on the virus surface, composed of three S1 and three S2 subunits. Infected and vaccinated individuals generate antibodies against spike, which can neutralize the virus. Most antibodie…
Phosphatidylserine Receptors Enhance SARS-CoV-2 Infection: AXL as a Therapeutic Target for COVID-19 Open
AUTHOR SUMMARY Phosphatidylserine (PS) receptors are PS binding proteins that mediate uptake of apoptotic bodies. Many enveloped viruses utilize this PS/PS receptor mechanism to adhere to and internalize into the endosomal compartment of c…
Frontline Science: CD40 signaling restricts RNA virus replication in Mϕs, leading to rapid innate immune control of acute virus infection Open
Many acute viral infections target tissue Mϕs, yet the mechanisms of Mϕ-mediated control of viruses are poorly understood. Here, we report that CD40 expressed by peritoneal Mϕs restricts early infection of a broad range of RNA viruses. Los…
IL-4/IL-13 polarization of macrophages enhances Ebola virus glycoprotein-dependent infection Open
These studies highlight the ability of macrophage polarization to influence EBOV GP-dependent virus replication in vivo and ex vivo, with M2a polarization upregulating cell surface receptor expression and thereby enhancing virus replicatio…