Dana E. Harmon
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View article: Disruption of the EmrAB-TolC efflux pump of Escherichia coli induces global metabolic changes in multiple growth conditions
Disruption of the EmrAB-TolC efflux pump of Escherichia coli induces global metabolic changes in multiple growth conditions Open
Multidrug efflux pumps are transporters that are important for the removal of exogenous toxic molecules in bacteria. Recently, efflux pumps have been implicated in the regulation of metabolic homeostasis in Escherichia coli. Here, we inves…
View article: Freshwater and Marine Environments in California Are a Reservoir of Carbapenem-Resistant Bacteria
Freshwater and Marine Environments in California Are a Reservoir of Carbapenem-Resistant Bacteria Open
Carbapenems are last-resort antibiotics used to treat multidrug-resistant bacterial infections. Resistance to carbapenems has been designated as an urgent threat and is increasing in healthcare settings. However, little is still known abou…
View article: The multidrug efflux pump regulator AcrR directly represses motility in <i>Escherichia coli</i>
The multidrug efflux pump regulator AcrR directly represses motility in <i>Escherichia coli</i> Open
Efflux and motility are two key biological functions in bacteria. Recent findings have shown that efflux impacts flagellum biosynthesis and motility in Escherichia coli and other bacteria. AcrR is known to be the major transcriptional repr…
View article: The Multidrug Efflux Regulator AcrR of Escherichia coli Responds to Exogenous and Endogenous Ligands To Regulate Efflux and Detoxification
The Multidrug Efflux Regulator AcrR of Escherichia coli Responds to Exogenous and Endogenous Ligands To Regulate Efflux and Detoxification Open
Multidrug efflux pumps can remove antibiotics and other toxic molecules from cells and are major contributors to antibiotic resistance and bacterial physiology. Therefore, it is essential to better understand their function and regulation.
View article: Urban and agricultural soils in Southern California are a reservoir of carbapenem‐resistant bacteria
Urban and agricultural soils in Southern California are a reservoir of carbapenem‐resistant bacteria Open
Carbapenems are last‐resort β‐lactam antibiotics used in healthcare facilities to treat multidrug‐resistant infections. Thus, most studies on identifying and characterizing carbapenem‐resistant bacteria (CRB) have focused on clinical setti…
View article: Comparative Genomics Reveals a Well-Conserved Intrinsic Resistome in the Emerging Multidrug-Resistant Pathogen Cupriavidus gilardii
Comparative Genomics Reveals a Well-Conserved Intrinsic Resistome in the Emerging Multidrug-Resistant Pathogen Cupriavidus gilardii Open
Cupriavidus gilardii is a bacterium that is gaining increasing attention both as an infectious agent and because of its potential use in the detoxification of toxic compounds and other biotechnological applications. In recent years, howeve…
View article: Prevalence and characterization of carbapenem‐resistant bacteria in water bodies in the Los Angeles–Southern California area
Prevalence and characterization of carbapenem‐resistant bacteria in water bodies in the Los Angeles–Southern California area Open
Carbapenems are β‐lactam antibiotics used in healthcare settings as last resort drugs to treat infections caused by antibiotic‐resistant bacteria. Carbapenem‐resistant bacteria are increasingly being isolated from healthcare facilities; ho…