Dana G. Wolf
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View article: Risk factors associated with cytomegalovirus reactivation and disease in critically-ill COVID-19 and non-COVID-19 patients, concomitantly admitted to intensive care
Risk factors associated with cytomegalovirus reactivation and disease in critically-ill COVID-19 and non-COVID-19 patients, concomitantly admitted to intensive care Open
Critically-ill patients are at increased risk for cytomegalovirus (CMV) reactivation, associated with adverse clinical outcomes. Given the surge in intensive care unit (ICU) admissions during the COVID-19 pandemic and the continued burden …
View article: Patterns and functional consequences of antibody speciation in maternal-fetal transfer of coronavirus-specific humoral immunity
Patterns and functional consequences of antibody speciation in maternal-fetal transfer of coronavirus-specific humoral immunity Open
Maternal antibodies serve as a temporary form of inherited immunity, providing humoral protection to vulnerable neonates. Whereas IgG is actively transferred up a concentration gradient via the neonatal Fc Receptor (FcRn), maternal IgA and…
View article: BNT162b2 vaccine induces potent SARS-CoV-2 neutralising immunoglobulins in lung mucosa
BNT162b2 vaccine induces potent SARS-CoV-2 neutralising immunoglobulins in lung mucosa Open
Introduction Functional aspects of pulmonary immunity to SARS-CoV-2 infection and BNT162b2 mRNA vaccination in humans and their correlation with upper airway and systemic immunity remain largely unexplored. The aim of the present study was…
View article: Risk factors for cytomegalovirus reactivation and disease in critically-ill COVID-19 and non-COVID-19 patients, concomitantly admitted to intensive care
Risk factors for cytomegalovirus reactivation and disease in critically-ill COVID-19 and non-COVID-19 patients, concomitantly admitted to intensive care Open
Background Critically-ill patients are at increased risk for cytomegalovirus (CMV) reactivation, associated with adverse clinical outcomes. Given the surge in intensive care unit (ICU) admissions during the COVID-19 pandemic and the contin…
View article: P-051 Antibodies in Seminal Fluid: A Potential Marker of Blood-Testis Barrier Integrity? A Prospective Clinical Trial
P-051 Antibodies in Seminal Fluid: A Potential Marker of Blood-Testis Barrier Integrity? A Prospective Clinical Trial Open
Study question Can the presence of specific acquired antibodies (Cytomegalovirus (CMV) IgG) or total IgG antibodies in seminal fluid, predict the outcomes in assisted reproductive technology (ART)? Summary answer IgG antibodies in seminal …
View article: Transfer of SARS-CoV-2 nucleocapsid protein to uninfected epithelial cells induces antibody-mediated complement deposition
Transfer of SARS-CoV-2 nucleocapsid protein to uninfected epithelial cells induces antibody-mediated complement deposition Open
SARS-CoV-2 infection triggers a strong antibody response toward nucleocapsid protein (NP), suggesting its extracellular presence beyond intravirion RNA binding. Our co-culture experiments show NP decorates infected and proximal uninfected …
View article: 380. Implementation of Pooled Saliva Tests for Universal Screening of Congenital Cytomegalovirus (cCMV) Infection: Lessons Derived Over a 25-Months Period
380. Implementation of Pooled Saliva Tests for Universal Screening of Congenital Cytomegalovirus (cCMV) Infection: Lessons Derived Over a 25-Months Period Open
Background cCMV infection is the most common intrauterine infection, leading to infant neurodevelopmental disabilities and hearing loss, which can manifest at birth or develop later during childhood. Currently, targeted screening of cCMV b…
View article: Risk Factors for Developing Adenovirus‐Associated Post‐Infectious Bronchiolitis Obliterans
Risk Factors for Developing Adenovirus‐Associated Post‐Infectious Bronchiolitis Obliterans Open
Background Risk factors for progression of adenovirus (AdV)‐associated bronchiolitis (AdV‐B) to post‐infectious bronchiolitis obliterans (PIBO) are poorly defined. We aimed to investigate this in a multicenter cohort. Methods A multicenter…
View article: Correction: Improved sensitivity, safety, and rapidity of COVID-19 tests by replacing viral storage solution with lysis buffer
Correction: Improved sensitivity, safety, and rapidity of COVID-19 tests by replacing viral storage solution with lysis buffer Open
[This corrects the article DOI: 10.1371/journal.pone.0249149.].
View article: Patterns and functional consequences of antibody speciation in maternal-fetal transfer of coronavirus-specific humoral immunity
Patterns and functional consequences of antibody speciation in maternal-fetal transfer of coronavirus-specific humoral immunity Open
Maternal antibodies serve as a temporary form of inherited immunity, providing humoral protection to vulnerable neonates. Whereas IgG is actively transferred up a concentration gradient via the neonatal Fc Receptor (FcRn), maternal IgA and…
View article: Consensus Definitions of Cytomegalovirus (CMV) Infection and Disease in Transplant Patients Including Resistant and Refractory CMV for Use in Clinical Trials: 2024 Update From the Transplant Associated Virus Infections Forum
Consensus Definitions of Cytomegalovirus (CMV) Infection and Disease in Transplant Patients Including Resistant and Refractory CMV for Use in Clinical Trials: 2024 Update From the Transplant Associated Virus Infections Forum Open
Cytomegalovirus (CMV) infection and disease are important causes of morbidity and mortality in transplant recipients. For the purpose of developing consistent reporting of CMV outcomes in clinical trials, definitions of CMV infection and d…
View article: Binding of SARS-CoV-2 nucleocapsid protein to uninfected epithelial cells induces antibody-mediated complement deposition
Binding of SARS-CoV-2 nucleocapsid protein to uninfected epithelial cells induces antibody-mediated complement deposition Open
SARS-CoV-2 infection triggers strong antibody response toward Nucleocapsid-Protein (NP), suggesting extracellular presence beyond its intra-virion RNA binding. Interestingly, NP was found to decorate infected and proximal uninfected cell-s…
View article: Implementation of pooled saliva tests for universal screening of cCMV infection
Implementation of pooled saliva tests for universal screening of cCMV infection Open
Congenital cytomegalovirus (cCMV) is the most common intrauterine infection, leading to neurodevelopmental disabilities. Universal newborn infant screening of cCMV has been increasingly advocated. In the absence of a high-throughput screen…
View article: Decidual-tissue-resident memory T cells protect against nonprimary human cytomegalovirus infection at the maternal-fetal interface
Decidual-tissue-resident memory T cells protect against nonprimary human cytomegalovirus infection at the maternal-fetal interface Open
Congenital cytomegalovirus (cCMV) is the most common intrauterine infection, leading to infant neurodevelopmental disabilities. An improved knowledge of correlates of protection against cCMV is needed to guide prevention strategies. Here, …
View article: A method for cleaning of used disposable plastic parts from automated <scp>RNA</scp> extraction system
A method for cleaning of used disposable plastic parts from automated <span>RNA</span> extraction system Open
During the first wave of COVID‐19 worldwide pandemic, the number of testing in Israel was severely affected by the shortage of reagents and consumables required to operate the instrument performing the sample extraction before the reverse …
View article: High rate of adenovirus detection in gastrointestinal biopsies of symptomatic stem cell transplant recipients
High rate of adenovirus detection in gastrointestinal biopsies of symptomatic stem cell transplant recipients Open
Objectives The gastrointestinal (GI) tract is a major human adenovirus (HAdV) replication site in patients undergoing hematopoietic stem cell transplantation (HSCT), yet the prevalence and correlates of HAdV GI infection in this setting ha…
View article: CLPTM1L is a GPI-anchoring pathway component targeted by HCMV
CLPTM1L is a GPI-anchoring pathway component targeted by HCMV Open
The GPI-anchoring pathway plays important roles in normal development and immune modulation. MHC Class I Polypeptide-related Sequence A (MICA) is a stress-induced ligand, downregulated by human cytomegalovirus (HCMV) to escape immune recog…
View article: Platelet count and risk of severe illness in hospitalised children with <scp>Influenza‐Like</scp> illness
Platelet count and risk of severe illness in hospitalised children with <span>Influenza‐Like</span> illness Open
Aim To examine the clinical significance of thrombocytosis (platelets > 500 × 10 9 /L) in admitted children with an influenza‐like illness. Methods We performed a database analysis consisting of patients evaluated at our medical centers wi…
View article: Pediatric respiratory admissions and related viral infections during the COVID‐19 pandemic
Pediatric respiratory admissions and related viral infections during the COVID‐19 pandemic Open
Introduction The COVID‐19 pandemic has affected the incidence of respiratory viral infections. Our aim was to assess changes in pediatric admissions due to respiratory diseases and associated respiratory viral infections. Methods An observ…
View article: Intramuscular mRNA BNT162b2 vaccine against SARS-CoV-2 induces neutralizing salivary IgA
Intramuscular mRNA BNT162b2 vaccine against SARS-CoV-2 induces neutralizing salivary IgA Open
Intramuscularly administered vaccines stimulate robust serum neutralizing antibodies, yet they are often less competent in eliciting sustainable “sterilizing immunity” at the mucosal level. Our study uncovers a strong temporary neutralizin…
View article: Thrombocytosis - a Marker of Disease Severity in Children with Viral Respiratory Tract Infections
Thrombocytosis - a Marker of Disease Severity in Children with Viral Respiratory Tract Infections Open
Background : Reactive thrombocytosis (Platelets >500K/μl) is estimated between 3-13% in hospitalized children and has been associated with RSV infection and younger age. We aimed to examine the clinical significance of thrombocytosis in ch…
View article: Boosting maternal and neonatal anti–SARS-CoV-2 humoral immunity using a third mRNA vaccine dose
Boosting maternal and neonatal anti–SARS-CoV-2 humoral immunity using a third mRNA vaccine dose Open
Israel Science Foundation KillCorona grant 3777/19; Research grant from the "Ofek" Program of the Hadassah Medical Center.
View article: Viral and Bacterial Respiratory Pathogens during the COVID-19 Pandemic in Israel
Viral and Bacterial Respiratory Pathogens during the COVID-19 Pandemic in Israel Open
Background: previous worldwide reports indicated a substantial short-term reduction in various respiratory infections during the early phase of the SARS-CoV-2 pandemic. Aims: exploring the long-term impact of the COVID-19 pandemic on respi…
View article: Specific clinical characteristics are correlated with long-term SARS CoV-2 IgG titers
Specific clinical characteristics are correlated with long-term SARS CoV-2 IgG titers Open
Purpose To investigate the correlation between various clinical characteristics and long-term SARS CoV-2 IgG following a COVID-19 outbreak in a school. Methods 532 sera of polymerase chain reaction (PCR)-tested children, adolescents and ad…
View article: Cytomegalovirus in the transplant setting: Where are we now and what happens next? A report from the International CMV Symposium 2021
Cytomegalovirus in the transplant setting: Where are we now and what happens next? A report from the International CMV Symposium 2021 Open
The CMV Symposium in September 2021 was an international conference dedicated to cytomegalovirus (CMV) infection after solid organ or hematopoietic stem cell transplantation. This review provides an overview of the presentations given by t…
View article: SARS-CoV-2 mRNA vaccination elicits broad and potent Fc effector functions to VOCs in vulnerable populations
SARS-CoV-2 mRNA vaccination elicits broad and potent Fc effector functions to VOCs in vulnerable populations Open
SARS-CoV-2 variants have continuously emerged even as highly effective vaccines have been widely deployed. Reduced neutralization observed against variants of concern (VOC) raises the question as to whether other antiviral antibody activit…
View article: Specific clinical characteristics are correlated with long-term SARS CoV-2 IgG titers
Specific clinical characteristics are correlated with long-term SARS CoV-2 IgG titers Open
Purpose To investigate the correlation between various clinical characteristics and long-term SARS CoV-2 IgG following a COVID-19 outbreak in a school. Methods 532 sera of polymerase chain reaction (PCR)-tested children, adolescents and ad…