Reza Dana
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View article: Naturally derived mucoadhesive nanosuspension for treatment of multiple staged ocular infections
Naturally derived mucoadhesive nanosuspension for treatment of multiple staged ocular infections Open
Bacterial ocular infections pose significant risks to vision and incur substantial economic burdens worldwide. Current standards of care, such as eye drops and ointments, suffer from poor drug bioavailability (70 %), and sustained in vitro…
View article: Topical Hepatocyte Growth Factor Accelerates Wound Healing and Inhibits Scarring in Experimental Corneal Injury
Topical Hepatocyte Growth Factor Accelerates Wound Healing and Inhibits Scarring in Experimental Corneal Injury Open
Purpose: The aim of this study was to compare the rates of healing, scar formation, and regression of preexisting scars using topical murine hepatocyte growth factor (mHGF), recombinant human deleted HGF (dHGF), murine nerve growth factor …
View article: Immune-mediated thrombotic thrombocytopenic purpura with systemic lupus erythematosus: clinical features and outcome
Immune-mediated thrombotic thrombocytopenic purpura with systemic lupus erythematosus: clinical features and outcome Open
Objective The association of immune-mediated thrombotic thrombocytopenic purpura (iTTP) and SLE was previously described, but patients with iTTP with coexistent SLE remain poorly characterised. Methods We compared the clinical presentation…
View article: Mucoadhesive micellar eyedrops for the treatment of ocular inflammation
Mucoadhesive micellar eyedrops for the treatment of ocular inflammation Open
Efficient ocular drug delivery remains a significant challenge in treating eye inflammation due to physiological barriers such as the tear film and frequent blinking, which lead to rapid drug clearance. Commercial eyedrops, like Oceanside®…
View article: Cultivated autologous limbal epithelial cell (CALEC) transplantation for limbal stem cell deficiency: a phase I/II clinical trial of the first xenobiotic-free, serum-free, antibiotic-free manufacturing protocol developed in the US
Cultivated autologous limbal epithelial cell (CALEC) transplantation for limbal stem cell deficiency: a phase I/II clinical trial of the first xenobiotic-free, serum-free, antibiotic-free manufacturing protocol developed in the US Open
We developed a two-stage manufacturing process utilizing cultivated autologous limbal epithelial cells (CALEC), the first xenobiotic-free, serum-free, antibiotic-free protocol developed in the United States, to treat blindness caused by un…
View article: Topical neurokinin-1 receptor antagonism ameliorates ocular pain and prevents corneal nerve degeneration in an animal model of dry eye disease
Topical neurokinin-1 receptor antagonism ameliorates ocular pain and prevents corneal nerve degeneration in an animal model of dry eye disease Open
Introduction: Ocular pain is a common complaint to eye care providers, associated with a variety of ocular conditions, among which dry eye disease (DED) is affecting millions of people worldwide. Despite being highly prevalent, ocular pain…
View article: TNF-α Suppression Attenuates Limbal Stem Cell Damage in Ocular Injury
TNF-α Suppression Attenuates Limbal Stem Cell Damage in Ocular Injury Open
Purpose: Ocular chemical injuries often cause uveal inflammation, upregulation of TNF-α at the limbus, and subsequent limbal stem cell (LSC) damage. In this study, we investigate the protective role of TNF-α suppression in LSC survival. Me…
View article: Activation of α2B/2C adrenergic receptor ameliorates ocular surface inflammation through enhancing regulatory T cell function
Activation of α2B/2C adrenergic receptor ameliorates ocular surface inflammation through enhancing regulatory T cell function Open
View article: Hepatocyte growth factor upregulates MMP1 and MMP10 expression and resolves corneal fibrosis
Hepatocyte growth factor upregulates MMP1 and MMP10 expression and resolves corneal fibrosis Open
Different therapeutic modalities, including steroids, have been used to treat corneal scarring. However, the ability of steroids to reduce corneal scarring is limited and associated with numerous side effects. Our previous studies have dem…
View article: A limbal stem cell deficiency murine model with residual limbal stem cells
A limbal stem cell deficiency murine model with residual limbal stem cells Open
Bilateral limbal stem cell deficiency (LSCD) is a significant cause of corneal blindness and is more difficult to treat, as compared with unilateral LSCD because no source of autologous limbal stem cells (LSCs) remains in these patients. T…
View article: Acquired immunostimulatory phenotype of migratory CD103+ DCs promotes alloimmunity following corneal transplantation
Acquired immunostimulatory phenotype of migratory CD103+ DCs promotes alloimmunity following corneal transplantation Open
After transplantation, Th1-mediated immune rejection is the predominant cause of graft failure. Th1 cell sensitization occurs through complex and context-dependent interaction among antigen-presenting cell subsets, particularly CD11b+ DCs …
View article: Assessment of Corneal Graft Outcomes in a Murine Model of Endothelial Keratoplasty
Assessment of Corneal Graft Outcomes in a Murine Model of Endothelial Keratoplasty Open
Objectives: In this study, we establish a protocol for evaluating the outcomes of endothelial keratoplasty, including graft survival, rejection, or failure. Additionally, we also evaluate the alloimmune response in graft recipients. Method…
View article: Small Fiber Neuropathy in Patients with Dry Eye Disease
Small Fiber Neuropathy in Patients with Dry Eye Disease Open
Purpose: Small-fiber neuropathy (SFN) refers to a range of peripheral neuropathic conditions affecting small-caliber sensory and/or autonomic nerve fibers. This study aims to determine the prevalence and characteristics of SFN symptoms in …
View article: Neuropeptide alpha-Melanocyte stimulating hormone preserves corneal endothelial morphology in a murine model of Fuchs dystrophy
Neuropeptide alpha-Melanocyte stimulating hormone preserves corneal endothelial morphology in a murine model of Fuchs dystrophy Open
View article: Potential applications of mesenchymal stem cells in ocular surface immune-mediated disorders
Potential applications of mesenchymal stem cells in ocular surface immune-mediated disorders Open
We explore the interaction between corneal immunity and mesenchymal stem/stromal cells (MSCs) and their potential in treating corneal and ocular surface disorders. We outline the cornea's immune privilege mechanisms and the immunomodulator…
View article: Contact lenses as novel tear fluid sampling vehicles for total RNA isolation, precipitation, and amplification
Contact lenses as novel tear fluid sampling vehicles for total RNA isolation, precipitation, and amplification Open
The tear fluid is a readily accessible, potential source for biomarkers of disease and could be used to monitor the ocular response to contact lens (CL) wear or ophthalmic pathologies treated by therapeutic CLs. However, the tear fluid rem…
View article: Local administration of myeloid-derived suppressor cells prevents progression of immune-mediated dry eye disease
Local administration of myeloid-derived suppressor cells prevents progression of immune-mediated dry eye disease Open
View article: Effects of Diabetes Mellitus on Corneal Immune Cell Activation and the Development of Keratopathy
Effects of Diabetes Mellitus on Corneal Immune Cell Activation and the Development of Keratopathy Open
Diabetes mellitus (DM) is one of the most prevalent diseases globally, and its prevalence is rapidly increasing. Most patients with a long-term history of DM present with some degree of keratopathy (DK). Despite its high incidence, the und…
View article: Suppression of Neovascularization by Topical and Subconjunctival Bevacizumab After High-Risk Corneal Transplantation
Suppression of Neovascularization by Topical and Subconjunctival Bevacizumab After High-Risk Corneal Transplantation Open
View article: Therapeutic Effects of Stimulating the Melanocortin Pathway in Regulating Ocular Inflammation and Cell Death
Therapeutic Effects of Stimulating the Melanocortin Pathway in Regulating Ocular Inflammation and Cell Death Open
Alpha-melanocyte-stimulating hormone (α-MSH) and its binding receptors (the melanocortin receptors) play important roles in maintaining ocular tissue integrity and immune homeostasis. Particularly extensive studies have demonstrated the bi…
View article: Effector T Cells Promote Fibrosis in Corneal Transplantation Failure
Effector T Cells Promote Fibrosis in Corneal Transplantation Failure Open
Fibrosis contributes to graft opacity in corneal transplant failure and is mediated at least in part by effector CD4+ T cells via IFN-γ.
View article: Epidermal Growth Factor Receptor Inhibitors for Lung Cancer and the Risk of Keratitis
Epidermal Growth Factor Receptor Inhibitors for Lung Cancer and the Risk of Keratitis Open
Importance Epidermal growth factor receptor inhibitors (EGFRis) have been reported to be associated with cutaneous and ocular side effects; however, there is limited evidence of an association between EGFRi treatment and keratitis. Objecti…
View article: Mucoadhesive Micellar Eyedrop for the Treatment of Ocular Inflammation
Mucoadhesive Micellar Eyedrop for the Treatment of Ocular Inflammation Open
View article: The Neuropeptide α-Melanocyte–Stimulating Hormone Prevents Persistent Corneal Edema following Injury
The Neuropeptide α-Melanocyte–Stimulating Hormone Prevents Persistent Corneal Edema following Injury Open
View article: Insights into mustard gas keratopathy- characterizing corneal layer-specific changes in mice exposed to nitrogen mustard
Insights into mustard gas keratopathy- characterizing corneal layer-specific changes in mice exposed to nitrogen mustard Open
View article: Cultivated autologous limbal epithelial cell (CALEC) transplantation: Development of manufacturing process and clinical evaluation of feasibility and safety
Cultivated autologous limbal epithelial cell (CALEC) transplantation: Development of manufacturing process and clinical evaluation of feasibility and safety Open
To treat unilateral limbal stem cell (LSC) deficiency, we developed cultivated autologous limbal epithelial cells (CALEC) using an innovative xenobiotic-free, serum-free, antibiotic-free, two-step manufacturing process for LSC isolation an…
View article: Opposing Roles of Blood-Borne Monocytes and Tissue-Resident Macrophages in Limbal Stem Cell Damage after Ocular Injury
Opposing Roles of Blood-Borne Monocytes and Tissue-Resident Macrophages in Limbal Stem Cell Damage after Ocular Injury Open
Limbal stem cell (LSC) deficiency is a frequent and severe complication after chemical injury to the eye. Previous studies have assumed this is mediated directly by the caustic agent. Here we show that LSC damage occurs through immune cell…
View article: The impact of donor diabetes on corneal transplant immunity
The impact of donor diabetes on corneal transplant immunity Open
View article: Possible Strategies to Mitigate Placebo or Vehicle Response in Dry Eye Disease Trials: A Narrative Review
Possible Strategies to Mitigate Placebo or Vehicle Response in Dry Eye Disease Trials: A Narrative Review Open
Many candidate drugs for dry eye disease (DED) have been assessed over the years in pursuit of demonstrating efficacy in both signs and symptoms. However, patients with DED have very limited treatment options for management of both signs a…
View article: Symptom-based stratification algorithm for heterogeneous symptoms of dry eye disease: a feasibility study
Symptom-based stratification algorithm for heterogeneous symptoms of dry eye disease: a feasibility study Open