Explanipedia

RENAL OUTCOMES IN PATIENTS TREATED WITH ANIFROLUMAB FOR SYSTEMIC LUPUS ERYTHEMATOSUS IN THE US: FINDINGS FROM A REAL-WORLD STUDY Open

Vasileios C. Kyttaris, Mawuena Binka, Gelareh Atefi, Derek Persons, Dana Withrow , et al. · 2025

PV245 / #126 Poster Topic: AS24 - SLE-Treatment Background/Purpose Renal disease is a common severe manifestation of systemic lupus erythematosus (SLE)[1] and renal function changes dynamically over time.[2] SLE treatment may stabilize ren…

0279 Impact of Insufficient Sleep on Respiratory Quotient and Substrate Utilization Open

Luisa Pereira Marot, Dana Withrow, Christopher M. Depner, Edward L. Melanson, Janine Higgins , et al. · 2025

Introduction Overeating and insufficient sleep have been reported to increase total daily carbohydrate utilization. Here we evaluated substrate utilization over 24h and specifically during nighttime hours under insufficient sleep condition…

0035 Effect of a Prebiotic Diet on 24-Hour Glucose Levels During Combined Sleep Restriction and Circadian Misalignment Open

Virginia M. Edwards, Sabrina Linton, Christopher M. Depner, Luisa Pereira Marot, Dana Withrow , et al. · 2025

Introduction Insufficient sleep and circadian misalignment dysregulate glucose homeostasis. Interventions are needed for when insufficient sleep and circadian misalignment cannot be avoided (e.g., military operations, emergency responders,…

0005 Duration of the Circadian Biological Night Differs Between Eight and Nine Hour Sleep Opportunities Open

Maeve Sheehy, Rebecca C. Cox, Alivia B. Blumenstein, Tina Burke, Christopher M. Depner , et al. · 2025

Introduction The duration between dim-light melatonin onset and offset represents the biological night, which tracks environmental darkness (i.e., scotoperiod). In humans, melatonin duration is longer after one week of exposure to natural …

0412 Better Objective Sleep in Healthy Adults Is Marked by Increased Bifidobacterium Breve and Saguini Open

Dana Withrow, Kate E. Sprecher, Antonio González, Frank E. Livingston, Ellis Noteboom , et al. · 2025

Introduction Taxa level associations of the human gut microbiota have been reported in relation to sleep health; however, which taxa are associated with good sleep has yet to be determined. Many study methodologies rely on self-reported sl…

Author Correction: Enhancing untargeted metabolomics using metadata-based source annotation Open

Julia M. Gauglitz, Kiana West, Wout Bittremieux, Candace L. Williams, Kelly C. Weldon , et al. · 2023

0201 Prebiotic Diet Impact on Cognitive Performance, Sleepiness, and Mood During Combined Sleep Restriction and Circadian Misalignment Open

Sarila Ekin, Dana Withrow, Abhignya Kuppa, Kate E. Sprecher, Monika Fleshner , et al. · 2023

Introduction The gut microbiome plays a crucial role in health and affects mood and behavior. The composition and function of the gut microbiome can be modified by prebiotics, which are defined as substrates selectively utilized by host mi…

0677 Blunted daily light rhythm amplitude in adults with opioid use disorder (OUD) Open

Rebecca Cox, Sophie Haller, Zofia Martinez-Lisowska, Abhignya Kuppa, Kate E. Sprecher , et al. · 2023

Introduction Accumulating evidence implicates sleep and circadian rhythm disruption in substance use disorders, including opioid use disorder (OUD). Blunted amplitude in daily rhythms of circadian-relevant variables (e.g., activity, light)…

Enhancing untargeted metabolomics using metadata-based source annotation Open

Julia M. Gauglitz, Kiana West, Wout Bittremieux, Candace L. Williams, Kelly C. Weldon , et al. · 2022

0220 Changes in Light Exposure During the Daylight Saving Time to Standard Time Transition Open

Sabrina Linton, Dana Withrow, Kenneth P. Wright, Katrina Rodheim · 2022

Introduction Although sunrise and sunset do not change, the Daylight Saving Time (DST) to Standard Time (ST) transition results in an earlier clock hour of sunrise and sunset. It has been hypothesized that ST results in brighter mornings a…

Reference data-set driven metabolomics Open

Julia M. Gauglitz, Kiana West, Wout Bittremieux, Candace L. Williams, Kelly C. Weldon , et al. · 2021

Human untargeted metabolomics studies succeed in annotating only ~10% of molecular features. We, therefore, introduce reference data-driven analysis that uses the source data as a pseudo-MS/MS reference library to match against human metab…

114 Stability of Gut Microbiome Alpha Diversity During Combined Sleep Restriction and Circadian Misalignment Open

Dana Withrow, Antonio González, Kate E. Sprecher, Christopher M. Depner, Tina Burke , et al. · 2021

Introduction Disturbed gut microbiome diversity has been associated with poor health outcomes and various disease states. We investigated the impact of combined sleep restriction (3h time in bed [TIB] sleep opportunities per day) and circa…

Sleep and circadian disruption and the gut microbiome-possible links to dysregulated metabolism Open

Dana Withrow, Samuel J. Bowers, Christopher M. Depner, Antonio González, Amy C. Reynolds , et al. · 2020

Reference data based insights expand understanding of human metabolomes Open

Julia M. Gauglitz, Wout Bittremieux, Candace L. Williams, Kelly C. Weldon, Morgan Panitchpakdi , et al. · 2020

Summary The human metabolome has remained largely unknown, with most studies annotating ∼10% of features. In nucleic acid sequencing, annotating transcripts by source has proven essential for understanding gene function. Here we generalize…

Sleep in university students prior to and during COVID-19 Stay-at-Home orders Open

Kenneth P. Wright, Sabrina Linton, Dana Withrow, Leandro P. Casiraghi, Shannon M. Lanza , et al. · 2020

0132 Sex Differences in Evening Food Intake and Associated Weight Gain During Insufficient Sleep Open

Dana Withrow, Christopher M. Depner, Elizabeth M Boland, Brian R. Birks, Edward L. Melanson , et al. · 2020

Introduction Timing of food intake has emerged as a novel risk factor for weight gain and obesity. Higher evening food intake, especially during insufficient sleep, is associated with weight gain. We aimed to explore initial changes in eve…

Sleep and pain in humans with fibromyalgia and comorbid insomnia: double-blind, crossover study of suvorexant 20 mg versus placebo Open

Timothy Roehrs, Dana Withrow, Gail Koshorek, Jelena Verkler, Luisa Bazan , et al. · 2020

Reference Data Based Insights Expand Understanding of Human Metabolomes Open

Julia M. Gauglitz, Wout Bittremieux, Candace L. Williams, Kelly C. Weldon, Morgan Panitchpakdi , et al. · 2020

Relation between ambulatory actigraphy and laboratory polysomnography in insomnia practice and research Open

Dana Withrow, Thomas Roth, Gail Koshorek, Timothy Roehrs · 2019

Actigraphy is increasingly used in practice and research studies because of its relative low cost and decreased subject burden. How multiple nights of at‐home actigraphy compare to one independent night of in‐laboratory polysomnography ( P…

0373 Effects of Suvorexant on Sleep in Fibromyalgia Open

Gail Koshorek, Jelena Verkler, Dana Withrow, Thomas Roth, Timothy Roehrs · 2019

The chronic pain disorder, fibromyalgia, is associated with sleep disturbance, typically sleep maintenance. Pharmacological treatment studies have either focused on the pain or the sleep disturbance with equivocal results in that few studi…

0374 Effects of Suvorexant on Pain Sensitivity in Fibromyalgia Open

Dana Withrow, Jelena Verkler, Gail Koshorek, Thomas Roth, Timothy Roehrs · 2019

The chronic widespread pain disorder, fibromyalgia, is known for its nociceptive hypersensitization and disturbed sleep. The relation of sleep and pain is bidirectional and data suggest that improving sleep in chronic pain disorders would …

0108 Insufficient Sleep Alters After-Dinner Consumption of High-Carbohydrate Snacks Open

Dana Withrow, Christopher M. Depner, Rachel R. Markwald, Edward L. Melanson, Leigh Perreault , et al. · 2019

Understanding mechanisms underlying the relationship between insufficient sleep and weight gain has importance for public health. Our previous findings showed, although total energy expenditure is higher during insufficient sleep, food int…

0378 Are People with Severe Insomnia Able to Discontinue Hypnotics after Chronic Use? Open

Gail Koshorek, Jelena Verkler, Dana Withrow, Thomas Roth, Timothy Roehrs · 2019

A concern among physicians prescribing hypnotics is the inability to discontinue hypnotics after chronic use. This concern has never been directly tested in a controlled prospective study. This is a report of results from an on-going “blin…

How representative are insomnia clinical trials? Open

Timothy Roehrs, Joris C. Verster, Gail Koshorek, Dana Withrow, Thomas Röth · 2018

0416 Inability to Discontinue Chronic Hypnotic Use Open

Gail Koshorek, Dana Withrow, Thomas Roth, Timothy Roehrs · 2018

Inability to discontinue chronic hypnotic use by people with insomnia remains a clinical concern. However, that inability has never been directly tested in a controlled prospective study using self-administration choice procedures. This is…

0374 Markers for Hypnotic Abuse Liability: Cortisol in Insomnia? Open

Timothy Roehrs, Gail Koshorek, Dana Withrow, Thomas Roth · 2018

It is hypothesized that stress increases vulnerability to drug abuse. Some insomniacs show hyperarousal by increased physiological responses to stress, elevated alertness on the Multiple Sleep Latency Test (MSLT) and elevated diurnal NE co…

0417 Self-reported Sleep during Discontinuation of Chronic Hypnotic Use Open

Dana Withrow, Gail Koshorek, Thomas Röth, Timothy Roehrs · 2018

Inability to discontinue chronic hypnotic use by people with insomnia remains a clinical concern. Self-reported sleep in an on-going “blinded” clinical trial in which people with insomnia are instructed to discontinue their study medicatio…

0331 ACTIGRAPHY IN INSOMNIA WITH AND WITHOUT EVENT-MARKING Open

Gail Koshorek, Dana Withrow, Thomas Röth, Timothy Roehrs · 2017

Use of actigraphy (ACT) in insomnia to objectively document sleep remains problematic primarily due to its insensitivity for wakefulness. One approach to enhancing validity is use of participant event marking to document time-in-bed (TIB).…

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