Dane Marijan
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View article: Protein thermal sensing regulates physiological amyloid aggregation
Protein thermal sensing regulates physiological amyloid aggregation Open
To survive, cells must respond to changing environmental conditions. One way that eukaryotic cells react to harsh stimuli is by forming physiological, RNA-seeded subnuclear condensates, termed amyloid bodies (A-bodies). The molecular const…
View article: Evolutionary conservation of systemic and reversible amyloid aggregation
Evolutionary conservation of systemic and reversible amyloid aggregation Open
In response to environmental stress, human cells have been shown to form reversible amyloid aggregates within the nucleus, termed amyloid bodies (A-bodies). These protective physiological structures share many of the biophysical characteri…
View article: Local translation in nuclear condensate amyloid bodies
Local translation in nuclear condensate amyloid bodies Open
Significance The central dogma of eukaryotic biology is clear: DNA replication and RNA transcription occur in the nucleus while protein synthesis takes place in the cytoplasm. While this fundamental tenet of biology is entrenched in textbo…
View article: Stress‐specific aggregation of proteins in the amyloid bodies
Stress‐specific aggregation of proteins in the amyloid bodies Open
Physiological amyloid aggregation occurs within the nuclei of stress‐treated cells. These structures, termed Amyloid bodies (A‐bodies), assemble through the rapid accumulation of proteins into dense membrane‐less organelles, which possess …