Danfeng Cai
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View article: Stress-induced loss of CTCF reveals an alternative, promoter-based mode of cohesin looping
Stress-induced loss of CTCF reveals an alternative, promoter-based mode of cohesin looping Open
Cells continually encounter environmental stressors that challenge homeostasis. How three-dimensional (3D) chromatin structure contributes to these stress responses, particularly under hyperosmotic conditions, remains poorly understood. He…
View article: METTL3 facilitates the translation of CircSIK2 during chicken myogenesis in an m6A dependent manner
METTL3 facilitates the translation of CircSIK2 during chicken myogenesis in an m6A dependent manner Open
Circular RNAs (circRNAs) are generally considered a new class of non-coding RNA (ncRNA) that frequently appears in the eukaryotic transcriptome. In principle, circRNAs may encode proteins, as some of them are generated from exons and posse…
View article: TEAD1 condensates are transcriptionally inactive storage sites on the pericentromeric heterochromatin
TEAD1 condensates are transcriptionally inactive storage sites on the pericentromeric heterochromatin Open
TEA domain transcription factor 1 (TEAD1), a Hippo pathway transcription factor important in cellular homeostasis and development, is increasingly implicated in cancer biology. Here, we reveal a novel role for TEAD1 in organizing nuclear c…
View article: Interferon-induced PARP14-mediated ADP-ribosylation in p62 bodies requires the ubiquitin-proteasome system
Interferon-induced PARP14-mediated ADP-ribosylation in p62 bodies requires the ubiquitin-proteasome system Open
Biomolecular condensates are cellular compartments without enveloping membranes, enabling them to dynamically adjust their composition in response to environmental changes through post-translational modifications. Recent work has revealed …
View article: YAP condensates are highly organized hubs
YAP condensates are highly organized hubs Open
YAP/TEAD signaling is essential for organismal development, cell proliferation, and cancer progression. As a transcriptional coactivator, how YAP activates its downstream target genes is incompletely understood. YAP forms biomolecular cond…
View article: Assessment of selective breeding effects and selection signatures in Qingyuan partridge chicken and its strains
Assessment of selective breeding effects and selection signatures in Qingyuan partridge chicken and its strains Open
Qingyuan partridge chicken (QYM) is a highly regarded native breed in China, highly esteemed for its exceptional breeding characteristics. However, the investigation into the selection signatures and its strains remains largely unexplored.…
View article: Transcriptional condensates and phase separation: condensing information across scales and mechanisms
Transcriptional condensates and phase separation: condensing information across scales and mechanisms Open
Transcription is the fundamental process of gene expression, which in eukaryotes occurs within the complex physicochemical environment of the nucleus. Decades of research have provided extreme detail in the molecular and functional mechani…
View article: Polymorphisms of CRELD1 and DNAJC30 and their relationship with chicken carcass traits
Polymorphisms of CRELD1 and DNAJC30 and their relationship with chicken carcass traits Open
Carcass traits play important roles in the broiler industry and single nucleotide polymorphism (SNP) can be efficient molecular markers for marker-assisted breeding of chicken carcass traits. Based on our previous RNA-seq data (accession n…
View article: YAP condensates are highly organized hubs for YAP/TEAD transcription
YAP condensates are highly organized hubs for YAP/TEAD transcription Open
Summary YAP/TEAD signaling is essential for organismal development, cell proliferation, and cancer progression. As a transcriptional coactivator, how YAP activates its downstream target genes is incompletely understood. YAP forms biomolecu…
View article: Transcriptome analysis of the inhibitory effect of cycloleucine on myogenesis
Transcriptome analysis of the inhibitory effect of cycloleucine on myogenesis Open
N6-Methyladenosine (m6A) has been reported to involve and play an important role in various biological activities but seldom in poultry myogenesis. Cycloleucine usually functions as a nucleic acid methylation inhibitor, the inhibition effi…
View article: RNA Sequencing Reveals the Regulation of Betaine on Chicken Myogenesis
RNA Sequencing Reveals the Regulation of Betaine on Chicken Myogenesis Open
Betaine is trimethylglycine and a universal methyl donor which could provide methyl and glycine for cells and animals. As a new star in epigenetics, N6-Methyladenosine has been reported to regulate multiple biological activities, but the r…
View article: Does Participation in Aquaculture Cooperatives Increase Farmers′ Profit and Output?
Does Participation in Aquaculture Cooperatives Increase Farmers′ Profit and Output? Open
Individual aquaculture farmers in developing countries play an important role in ensuring food security. This study uses survey data from aquaculture households in Rongcheng and Xiangshan cities in China to explore the impact of cooperativ…
View article: CircMGA Depresses Myoblast Proliferation and Promotes Myotube Formation through miR-144-5p/FAP Signal
CircMGA Depresses Myoblast Proliferation and Promotes Myotube Formation through miR-144-5p/FAP Signal Open
Circular RNAs are endogenous and abundant in skeletal muscle, and may not only be involved in regulating gene expression in a variety of ways, but also function as important regulators in poultry muscle development. Our previous research f…
View article: circTAF8 Regulates Myoblast Development and Associated Carcass Traits in Chicken
circTAF8 Regulates Myoblast Development and Associated Carcass Traits in Chicken Open
Recent studies have shown that circular RNAs (circRNAs) play important roles in skeletal muscle development. CircRNA biogenesis is dependent on the genetic context. Single-nucleotide polymorphisms in the introns flanking circRNAs may be in…