Danfu Ma
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Effects of trans-mitral flow patterns and heart rate on intraventricular pressure gradients and E/E’ in the early stage of a rat model of hypertensive cardiomyopathy Open
Background The mitral inflow spectral is expressed as two separate waves: early diastolic trans-mitral flow velocity (E) and late diastolic trans-mitral flow velocity (A) waves. When the heart rate (HR) increases and the diastolic time dim…
Adipose Stem Cell-Seeded Decellularized Porcine Pericardium: A Promising Functional Biomaterial to Synergistically Restore the Cardiac Functions Post-Myocardial Infarction Open
Myocardial infarction (MI) is a serious cardiovascular disease as the leading cause of death globally. Hence, reconstruction of the cardiac tissue comes at the forefront of strategies adopted to restore heart functions following MI. In thi…
Intraventricular pressure gradient: A novel tool to assess the post-infarction chronic congestive heart failure Open
Congestive heart failure (CHF), the leading cause of death, is deemed a grave sequel of myocardial infarction (MI). The employment of left ventricular end-diastolic pressure (LVEDP), as a primary indication of CHF, becomes restricted owing…
Cultured versus freshly isolated adipose-derived stem cells in improvement of the histopathological outcomes in HCL-induced cystitis in a rat model Open
Interstitial cystitis (IC) is an incurable chronic disease. The etiology of IC is unclear, and no effective therapies have been established. Here, using a hydrogen chloride (HCL)-induced IC in a rat model, the therapeutic potency of stroma…
Changes in Cardiac Function During the Development of Uremic Cardiomyopathy and the Effect of Salvianolic Acid B Administration in a Rat Model Open
Background Uremic cardiomyopathy (UC), the main cause of death in progressive chronic kidney disease (CKD), is characterized by diastolic dysfunction. Intraventricular pressure gradients (IVPG) derived from color m-mode echocardiography (C…
Clinical and diagnostic approach of male pseudo hermaphroditism with os‐clitoris in French bulldog: A case report Open
Introduction Hermaphroditism is less frequently reported in dogs and is often associated with infertility. Case report An 8‐month‐old French bulldog weighing 5 kg with an enlarged structure protruding from the vulva was clinically diagnose…
Evaluation of Changes in the Cardiac Function before and after Transcatheter Edge-to-Edge Mitral Valve Repair in Healthy Dogs: Conventional and Novel Echocardiography Open
Mitral valve regurgitation is a common canine heart disease. Transcatheter Edge-to-Edge Repair (TEER) is a transcatheter, edge-to-edge mitral repair device that uses a hybrid approach. No detailed information has been published on the hemo…
Effect of Loading Changes on the Intraventricular Pressure Measured by Color M-Mode Echocardiography in Rats Open
Evaluation of diastolic function is a pivotal challenge due to limitations of the conventional echocardiography, especially when the heart rate is rapid as in rats. Currently, by using color M-mode echocardiography (CMME), intraventricular…
Expression of cardiac copper chaperone encoding genes and their correlation with cardiac function parameters in goats Open
The expression of copper chaperone (Cu-Ch) encoding genes enables an in-depth understanding of copper-associated disorders, but no previous studies have been undertaken to highlight Cu-Ch disturbances in heart tissue in ruminants after cop…
Tissue Harvesting Site Effect on the Canine Adipose Stromal Vascular Fraction Quantity and Quality Open
Mesenchymal stem cells (MSCs) constitute a great promise for regenerative therapy, but these cells are difficultly recovered in large amounts. A potent alternative is the stromal vascular fraction (SVF), non-cultured MSCs, separated from a…
Intraventricular pressure gradients change during the development of left ventricular hypertrophy: Effect of salvianolic acid B and beta-blocker Open
Introduction Intraventricular pressure gradient is regarded as a non-invasive indicator of diastolic function. Salvianolic acid B (Sal-B), a traditional Asian medicine, revealed its usefulness in myocardial infarction models; however, the …
Assessment of the Cardiac Functions Using Full Conventional Echocardiography with Tissue Doppler Imaging before and after Xylazine Sedation in Male Shiba Goats Open
The present study aimed to provide a complete conventional echocardiographic protocol in adult male Shiba goats by using two-dimensional, M-mode, Pulsed Wave Doppler, and tissue Doppler imaging (TDI) echocardiography, and to study concomit…
Effects of Individual and Coexisting Diabetes and Cardiomyopathy on Diastolic Function in Rats (<i>Rattus norvegicus domestica</i>) Open
The goal of this study was to evaluate diastolic intraventricular pressure gradients (IVPG) and 2-dimensional tissue tracking (2DTT) patterns during diabetes and cardiomyopathy. Rats ( n = 60) were induced to become diabetic (DM group, n =…
Metformin prevents the development of monocrotaline‑induced pulmonary hypertension by decreasing serum levels of big endothelin‑1 Open
Pulmonary hypertension (PH) is a disease with poor prognosis, and it is characterized by the progressive elevation of pulmonary vascular resistance and pressure. Various factors are associated with the pathology of PH, including AMP-activa…
Balloon valvuloplasty in two dogs with aortic valve stenosis showing congestive heart failure Open
A 10-year-old female Papillon and a 1-year-old male Golden Retriever were presented to the Tokyo University of Agriculture and Technology for a second opinion on an aortic valve stenosis (AS). The aortic flow rate was not as high as it sho…