Danica J. Walsh
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View article: Phenyl urea based adjuvants for β-lactam antibiotics against methicillin resistant Staphylococcus aureus
Phenyl urea based adjuvants for β-lactam antibiotics against methicillin resistant Staphylococcus aureus Open
View article: Entdeckung von Fragmenten durch Röntgenkristallografisches Screening, die auf die CTP‐Bindungsstelle von <i>Pseudomonas Aeruginosa</i> IspD Abzielen
Entdeckung von Fragmenten durch Röntgenkristallografisches Screening, die auf die CTP‐Bindungsstelle von <i>Pseudomonas Aeruginosa</i> IspD Abzielen Open
Da die antimikrobielle Resistenz (AMR) ein alarmierendes Ausmaß erreicht hat, werden dringend neue Antiinfektiva mit bisher unbekannten Wirkmechanismen benötigt. Der 2‐ C‐ Methylerythritol‐D‐erythritol‐4‐phosphat (MEP)‐Weg stellt eine attr…
View article: Fragment Discovery by X‐Ray Crystallographic Screening Targeting the CTP Binding Site of <i>Pseudomonas Aeruginosa</i> IspD
Fragment Discovery by X‐Ray Crystallographic Screening Targeting the CTP Binding Site of <i>Pseudomonas Aeruginosa</i> IspD Open
With antimicrobial resistance (AMR) reaching alarming levels, new anti‐infectives with unprecedented mechanisms of action are urgently needed. The 2‐ C ‐methylerythritol‐D‐erythritol‐4‐phosphate (MEP) pathway represents an attractive sourc…
View article: IspE kinase as an anti-infective target: Role of a hydrophobic pocket in inhibitor binding
IspE kinase as an anti-infective target: Role of a hydrophobic pocket in inhibitor binding Open
Enzymes of the methylerythritol phosphate (MEP) pathway are potential targets for antimicrobial drug discovery. Here, we focus on 4-diphosphocytidyl-2-C-methyl-D-erythritol (IspE) kinase from the MEP pathway. We use biochemical and structu…
View article: IspE Kinase as an Anti-infective Target: Role of a Hydrophobic Pocket in Inhibitor Binding
IspE Kinase as an Anti-infective Target: Role of a Hydrophobic Pocket in Inhibitor Binding Open
Enzymes of the methylerythritol phosphate (MEP) pathway are potential targets for antimicrobial drug discovery. Here we focus on 4-diphosphocytidyl-2-C-methyl-D-erythritol (IspE) kinase from the MEP pathway. We use biochemical and structur…
View article: Development of phenyl‐urea‐based small molecules that target penicillin‐binding protein 4
Development of phenyl‐urea‐based small molecules that target penicillin‐binding protein 4 Open
Staphylococcus aureus has the ability to invade cortical bone osteocyte lacuno‐canalicular networks (OLCNs) and cause osteomyelitis. It was recently established that the cell wall transpeptidase, penicillin‐binding protein 4 (PBP4), is cru…
View article: New Genetically Engineered Derivatives of Antibacterial Darobactins Underpin Their Potential for Antibiotic Development
New Genetically Engineered Derivatives of Antibacterial Darobactins Underpin Their Potential for Antibiotic Development Open
Biosynthetic engineering of bicyclic darobactins, selectively sealing the lateral gate of the outer membrane protein BamA, leads to active analogues, which are up to 128-fold more potent against Gram-negative pathogens compared to native c…
View article: New Genetically Engineered Derivatives of Antibacterial Darobac-tins Underpin their Potential for Antibiotic Development
New Genetically Engineered Derivatives of Antibacterial Darobac-tins Underpin their Potential for Antibiotic Development Open
Biosynthetic engineering of bi–cyclic darobactins, which selectively seal the lateral gate of the outer membrane pro-tein BamA, lead to highly active analogues which are up to 128–fold more potent against critical and clinically relevant G…
View article: Advanced Glycation End Products as a Potential Target for Restructuring the Ovarian Cancer Microenvironment: A Pilot Study
Advanced Glycation End Products as a Potential Target for Restructuring the Ovarian Cancer Microenvironment: A Pilot Study Open
Ovarian cancer is the sixth leading cause of cancer-related death in women, and both occurrence and mortality are increased in women over the age of 60. There are documented age-related changes in the ovarian cancer microenvironment that h…
View article: Identification of Staphylococcus aureus Penicillin Binding Protein 4 (PBP4) Inhibitors
Identification of Staphylococcus aureus Penicillin Binding Protein 4 (PBP4) Inhibitors Open
Methicillin-resistant Staphylococcus aureus (MRSA) is a global healthcare concern. Such resistance has historically been attributed to the acquisition of mecA (or mecC), which encodes an alternative penicillin binding protein, PBP2a, with …
View article: Novel Nitro-Heteroaromatic Antimicrobial Agents for the Control and Eradication of Biofilm-Forming Bacteria
Novel Nitro-Heteroaromatic Antimicrobial Agents for the Control and Eradication of Biofilm-Forming Bacteria Open
The synthesis and biological activity of several novel nitrothiazole, nitrobenzothiazole, and nitrofuran containing antimicrobial agents for the eradication of biofilm-forming Gram-negative and Gram-positive pathogens is described. Nitazox…
View article: Design, synthesis, and evaluation of novel antimicrobials for the eradication of biofilms
Design, synthesis, and evaluation of novel antimicrobials for the eradication of biofilms Open
The majority of microorganisms live in association with surfaces as biofilms. Biofilm communities are encased in a robust, extracellular matrix that reduces their susceptibility to antimicrobial agents. This poses a health concern due to t…
View article: Novel phenolic antimicrobials enhanced activity of iminodiacetate prodrugs against biofilm and planktonic bacteria
Novel phenolic antimicrobials enhanced activity of iminodiacetate prodrugs against biofilm and planktonic bacteria Open
Prodrugs are pharmacologically attenuated derivatives of drugs that undergo bioconversion into the active compound once reaching the targeted site, thereby maximizing their efficiency. This strategy has been implemented in pharmaceuticals …
View article: Sulfenate Esters of Simple Phenols Exhibit Enhanced Activity against Biofilms
Sulfenate Esters of Simple Phenols Exhibit Enhanced Activity against Biofilms Open
The recalcitrance exhibited by microbial biofilms to conventional disinfectants has motivated the development of new chemical strategies to control and eradicate biofilms. The activities of several small phenolic compounds and their trichl…
View article: Antimicrobial Activity of Naturally Occurring Phenols and Derivatives Against Biofilm and Planktonic Bacteria
Antimicrobial Activity of Naturally Occurring Phenols and Derivatives Against Biofilm and Planktonic Bacteria Open
Biofilm-forming bacteria present formidable challenges across diverse settings, and there is a need for new antimicrobial agents that are both environmentally acceptable and relatively potent against microorganisms in the biofilm state. Th…
View article: Light-based 3D printing of hydrogels with high-resolution channels
Light-based 3D printing of hydrogels with high-resolution channels Open
Hydrogels are soft, water-based gels with widespread applications in personal care products, medicine and biomedical engineering. Many applications require structuring the hydrogel into complex three-dimensional (3D) shapes. For these appl…