Daniel A. Barbash
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View article: The <i>Stellate</i> meiotic drive system of <i>Drosophila melanogaster</i> is active in contemporary populations
The <i>Stellate</i> meiotic drive system of <i>Drosophila melanogaster</i> is active in contemporary populations Open
Meiotic drivers are selfish elements that bias their own transmission so that they are overrepresented among the functional gametes produced. The selective costs imposed by drivers on their hosts may trigger intragenomic conflict, promotin…
View article: The Structure of Simple Satellite Variation in the Human Genome and Its Correlation With Centromere Ancestry
The Structure of Simple Satellite Variation in the Human Genome and Its Correlation With Centromere Ancestry Open
Although repetitive DNA forms much of the human genome, its study is challenging due to limitations in assembly and alignment of repetitive short-reads. We have deployed k-Seek, software that detects tandem repeats embedded in single reads…
View article: Testing a candidate meiotic drive locus identified by pool sequencing
Testing a candidate meiotic drive locus identified by pool sequencing Open
Meiotic drive biases the transmission of alleles in heterozygous individuals, such that Mendel's law of equal segregation is violated. Most examples of meiotic drive have been discovered over the past century based on causing sex ratio dis…
View article: Testing the Drosophila <i>maternal haploid</i> gene for functional divergence and a role in hybrid incompatibility
Testing the Drosophila <i>maternal haploid</i> gene for functional divergence and a role in hybrid incompatibility Open
Crosses between Drosophila simulans females and Drosophila melanogaster males produce viable F1 sons and poorly viable F1 daughters. Unlike most hybrid incompatibilities, this hybrid incompatibility violates Haldane’s rule, the observation…
View article: Divergent selection on behavioural and chemical traits between reproductively isolated populations of <i>Drosophila melanogaster</i>
Divergent selection on behavioural and chemical traits between reproductively isolated populations of <i>Drosophila melanogaster</i> Open
Speciation is driven by traits that can act to prevent mating between nascent lineages, including male courtship and female preference for male traits. Mating barriers involving these traits evolve quickly because there is strong selection…
View article: Stonewall prevents expression of ectopic genes in the ovary and accumulates at insulator elements in D. melanogaster
Stonewall prevents expression of ectopic genes in the ovary and accumulates at insulator elements in D. melanogaster Open
Germline stem cells (GSCs) are the progenitor cells of the germline for the lifetime of an animal. In Drosophila , these cells reside in a cellular niche that is required for both their maintenance (self-renewal) and differentiation (asymm…
View article: Testing the Drosophila <i>maternal haploid</i> gene for functional divergence and a role in hybrid incompatibility
Testing the Drosophila <i>maternal haploid</i> gene for functional divergence and a role in hybrid incompatibility Open
Crosses between D. simulans females and D. melanogaster males produce viable F1 sons and poorly viable F1 daughters. Unlike most hybrid incompatibilities, this hybrid incompatibility violates Haldane’s rule, the observation that incompatib…
View article: Stonewall prevents expression of testis-enriched genes and binds to insulator elements in<i>D. melanogaster</i>
Stonewall prevents expression of testis-enriched genes and binds to insulator elements in<i>D. melanogaster</i> Open
Germline stem cells (GSCs) are the progenitor cells of the germline for the lifetime of an animal. In Drosophila , these cells reside in a cellular niche that is required for both their maintenance (self-renewal) and differentiation (asymm…
View article: Rapid evolution at the Drosophila telomere: transposable element dynamics at an intrinsically unstable locus
Rapid evolution at the Drosophila telomere: transposable element dynamics at an intrinsically unstable locus Open
Drosophila telomeres have been maintained by three families of active transposable elements (TEs), HeT-A, TAHRE, and TART, collectively referred to as HTTs, for tens of millions of years, which contrasts with an unusually high degree of HT…
View article: Divergent selection on behavioral and chemical traits contributes to isolation between populations of<i>Drosophila melanogaster</i>
Divergent selection on behavioral and chemical traits contributes to isolation between populations of<i>Drosophila melanogaster</i> Open
Speciation is driven by traits that can act to prohibit mating between nascent lineages, including male courtship and female preference for male traits. Mating barriers involving these traits evolve quickly because there is strong selectio…
View article: Adaptive evolution among cytoplasmic piRNA proteins leads to decreased genomic auto-immunity
Adaptive evolution among cytoplasmic piRNA proteins leads to decreased genomic auto-immunity Open
In metazoan germlines, the piRNA pathway acts as a genomic immune system, employing small RNA-mediated silencing to defend host DNA from the harmful effects of transposable elements (TEs). Expression of genomic TEs is proposed to initiate …
View article: Special Issue: Repetitive DNA Sequences
Special Issue: Repetitive DNA Sequences Open
Repetitive DNAs are ubiquitous in eukaryotic genomes and, in many species, comprise the bulk of the genome. Repeats include transposable elements that can self-mobilize and disperse around the genome and tandemly-repeated satellite DNAs th…
View article: Adaptive evolution among cytoplasmic piRNA proteins leads to decreased genomic auto-immunity
Adaptive evolution among cytoplasmic piRNA proteins leads to decreased genomic auto-immunity Open
In metazoan germlines, the piRNA pathway acts as a genomic immune system, employing small RNA-mediated silencing to defend host DNA from the harmful effects of transposable elements (TEs). In response to dynamic changes in TE content, host…
View article: Rates and Patterns of Mutation in Tandem Repetitive DNA in Six Independent Lineages of Chlamydomonas reinhardtii
Rates and Patterns of Mutation in Tandem Repetitive DNA in Six Independent Lineages of Chlamydomonas reinhardtii Open
The mutational patterns of large tandem arrays of short sequence repeats remain largely unknown, despite observations of their high levels of variation in sequence and genomic abundance within and between species. Many factors can influenc…
View article: Double insertion of transposable elements provides a substrate for the evolution of satellite DNA
Double insertion of transposable elements provides a substrate for the evolution of satellite DNA Open
Eukaryotic genomes are replete with repeated sequences in the form of transposable elements (TEs) dispersed across the genome or as satellite arrays, large stretches of tandemly repeated sequences. Many satellites clearly originated as TEs…
View article: Variable Rates of Simple Satellite Gains across the Drosophila Phylogeny
Variable Rates of Simple Satellite Gains across the Drosophila Phylogeny Open
Simple satellites are tandemly repeating short DNA motifs that can span megabases in eukaryotic genomes. Because they can cause genomic instability through nonallelic homologous exchange, they are primarily found in the repressive heteroch…
View article: Moving Speciation Genetics Forward: Modern Techniques Build on Foundational Studies in <i>Drosophila</i>
Moving Speciation Genetics Forward: Modern Techniques Build on Foundational Studies in <i>Drosophila</i> Open
The question of how new species evolve has been examined at every level, from macroevolutionary patterns of diversification to molecular population genetic analyses of specific genomic regions between species pairs. Drosophila has been at …
View article: The Hybrid Incompatibility Genes <i>Lhr</i> and <i>Hmr</i> Are Required for Sister Chromatid Detachment During Anaphase but Not for Centromere Function
The Hybrid Incompatibility Genes <i>Lhr</i> and <i>Hmr</i> Are Required for Sister Chromatid Detachment During Anaphase but Not for Centromere Function Open
Crosses between Drosophila melanogaster females and Drosophila simulans males produce hybrid sons that die at the larval stage. This hybrid lethality is suppressed by loss-of-function mutations in the D. melanogaster Hybrid male rescue (Hm…
View article: <i>Lhr</i>and<i>Hmr</i>are required for sister chromatid detachment during anaphase but not for centromere function
<i>Lhr</i>and<i>Hmr</i>are required for sister chromatid detachment during anaphase but not for centromere function Open
Crosses between Drosophila melanogaster females and Drosophila simulans males produce hybrid sons that die at the larval stage. This hybrid lethality is suppressed by loss-of-function mutations in the D. melanogaster Hybrid male rescue ( H…
View article: Double insertion of transposable elements provides a substrate for the evolution of satellite DNA
Double insertion of transposable elements provides a substrate for the evolution of satellite DNA Open
Eukaryotic genomes are replete with repeated sequences, in the form of transposable elements (TEs) dispersed across the genome or as satellite arrays, large stretches of tandemly repeated sequence. Many satellites clearly originated as TEs…
View article: A Pooled Sequencing Approach Identifies a Candidate Meiotic Driver in <i>Drosophila</i>
A Pooled Sequencing Approach Identifies a Candidate Meiotic Driver in <i>Drosophila</i> Open
Mendel’s Law of equal segregation states that each of the two alleles in a diploid organism has an equal probability of being transmitted into... Meiotic drive occurs when a selfish element increases its transmission frequency above the Me…
View article: A pooled sequencing approach identifies a candidate meiotic driver in Drosophila
A pooled sequencing approach identifies a candidate meiotic driver in Drosophila Open
Meiotic drive occurs when a selfish element increases its transmission frequency above the Mendelian ratio by hijacking the asymmetric divisions of female meiosis. Meiotic drive causes genomic conflict and potentially has a major impact on…
View article: The Drosophila bag of marbles Gene Interacts Genetically with Wolbachia and Shows Female-Specific Effects of Divergence
The Drosophila bag of marbles Gene Interacts Genetically with Wolbachia and Shows Female-Specific Effects of Divergence Open
Many reproductive proteins from diverse taxa evolve rapidly and adaptively. These proteins are typically involved in late stages of reproduction such as sperm development and fertilization, and are more often functional in males than femal…
View article: Never Settling Down: Frequent Changes in Sex Chromosomes
Never Settling Down: Frequent Changes in Sex Chromosomes Open
A new study reveals multiple dramatic changes in sex chromosome structure and identity in flies; such transitions are accompanied by a series of genomic events that affect chromosome biology, gene regulation, and sex determination. See the…
View article: Adaptive Evolution of Genes Involved in the Regulation of Germline Stem Cells in<i>Drosophila melanogaster</i>and<i>D. simulans</i>
Adaptive Evolution of Genes Involved in the Regulation of Germline Stem Cells in<i>Drosophila melanogaster</i>and<i>D. simulans</i> Open
Population genetic and comparative analyses in diverse taxa have shown that numerous genes involved in reproduction are adaptively evolving. Two genes involved in germline stem cell regulation, bag of marbles (bam) and benign gonial cell n…