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View article: Structure of SHOC2-KRAS-PP1C complex reveals RAS isoform-specific determinants and insights into targeting complex assembly by RAS inhibitors
Structure of SHOC2-KRAS-PP1C complex reveals RAS isoform-specific determinants and insights into targeting complex assembly by RAS inhibitors Open
RAF activation is essential for MAPK signaling and is mediated by RAS binding and the dephosphorylation of a conserved phosphoserine by the SHOC2–RAS–PP1C complex. MRAS forms a high-affinity SHOC2–MRAS–PP1C (SMP) complex, while canonical R…
View article: RAS and SHOC2 Roles in RAF Activation and Therapeutic Considerations
RAS and SHOC2 Roles in RAF Activation and Therapeutic Considerations Open
Mutations in RAS proteins play a pivotal role in the development of human cancers, driving persistent RAF activation and deregulating the mitogen-activated protein kinase (MAPK) signaling pathway. While progress has been made in targeting …
View article: An unbroken network of interactions connecting flagellin domains is required for motility in viscous environments
An unbroken network of interactions connecting flagellin domains is required for motility in viscous environments Open
In its simplest form, bacterial flagellar filaments are composed of flagellin proteins with just two helical inner domains, which together comprise the filament core. Although this minimal filament is sufficient to provide motility in many…
View article: The ribosomal S6 kinase 2 (RSK2)–SPRED2 complex regulates the phosphorylation of RSK substrates and MAPK signaling
The ribosomal S6 kinase 2 (RSK2)–SPRED2 complex regulates the phosphorylation of RSK substrates and MAPK signaling Open
Sprouty-related EVH-1 domain-containing (SPRED) proteins are a family of proteins that negatively regulate the RAS-Mitogen-Activated Protein Kinase (MAPK) pathway, which is involved in the regulation of the mitogenic response and cell prol…
View article: Structural insights into the role of <scp>SHOC2‐MRAS‐PP1C</scp> complex in <scp>RAF</scp> activation
Structural insights into the role of <span>SHOC2‐MRAS‐PP1C</span> complex in <span>RAF</span> activation Open
RAF activation is a key step for signalling through the mitogen‐activated protein kinase (MAPK) pathway. The SHOC2 protein, along with MRAS and PP1C, forms a high affinity, heterotrimeric holoenzyme that activates RAF kinases by dephosphor…
View article: An unbroken network of interactions connecting flagellin domains is required for motility in viscous environments
An unbroken network of interactions connecting flagellin domains is required for motility in viscous environments Open
In its simplest form, bacterial flagellar filaments are composed of flagellin proteins with just two helical inner domains, which together comprise the filament core. Although this minimal filament is sufficient to provide motility in many…
View article: Structure of the SHOC2–MRAS–PP1C complex provides insights into RAF activation and Noonan syndrome
Structure of the SHOC2–MRAS–PP1C complex provides insights into RAF activation and Noonan syndrome Open
SHOC2 acts as a strong synthetic lethal interactor with MEK inhibitors in multiple KRAS cancer cell lines. SHOC2 forms a heterotrimeric complex with MRAS and PP1C that is essential for regulating RAF and MAPK-pathway activation by dephosph…
View article: Structural basis of the dynamic human CEACAM1 monomer-dimer equilibrium
Structural basis of the dynamic human CEACAM1 monomer-dimer equilibrium Open
Human (h) carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) function depends upon IgV-mediated homodimerization or heterodimerization with host ligands, including hCEACAM5, hTIM-3, PD-1, and a variety of microbial pathoge…
View article: Bacterial protein domains with a novel Ig‐like fold target human CEACAM receptors
Bacterial protein domains with a novel Ig‐like fold target human CEACAM receptors Open
Streptococcus agalactiae, also known as group B Streptococcus (GBS), is the major cause of neonatal sepsis in humans. A critical step to infection is adhesion of bacteria to epithelial surfaces. GBS adhesins have been identified to bind ex…
View article: Equine pregnancy-specific glycoprotein CEACAM49 secreted by endometrial cup cells activates TGFB
Equine pregnancy-specific glycoprotein CEACAM49 secreted by endometrial cup cells activates TGFB Open
In early equine pregnancy, a highly invasive trophoblast cell subpopulation, the chorionic girdle cells, invade the endometrium and form endometrial cups (EC). These cells express classical MHC molecules, thereby stimulating a humoral and …
View article: Structural basis of the dynamic human CEACAM1 monomer-dimer equilibrium
Structural basis of the dynamic human CEACAM1 monomer-dimer equilibrium Open
Human (h) carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) function depends upon IgV-mediated homodimerization or heterodimerization with host ligands, including hCEACAM5 and hTIM-3, and a variety of microbial pathogens.…
View article: Bacterial protein domains with a novel Ig-like fold target human CEACAM receptors
Bacterial protein domains with a novel Ig-like fold target human CEACAM receptors Open
Streptococcus agalactiae , also known as group B Streptococcus (GBS), is the major cause of neonatal sepsis in humans. A critical step to infection is adhesion of bacteria at mucosal surfaces. Though several GBS adhesins have been identifi…
View article: Bacterial flagellar capping proteins adopt diverse oligomeric states
Bacterial flagellar capping proteins adopt diverse oligomeric states Open
Flagella are crucial for bacterial motility and pathogenesis. The flagellar capping protein (FliD) regulates filament assembly by chaperoning and sorting flagellin (FliC) proteins after they traverse the hollow filament and exit the growin…
View article: Author response: Bacterial flagellar capping proteins adopt diverse oligomeric states
Author response: Bacterial flagellar capping proteins adopt diverse oligomeric states Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Flagella are crucial for bact…