Daniel A. Lim
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View article: A Niche for Adult Neurogenesis: Analysis of BMP Signaling and Transcriptional Profiles of Adult Subventricular Zone Cells
A Niche for Adult Neurogenesis: Analysis of BMP Signaling and Transcriptional Profiles of Adult Subventricular Zone Cells Open
Neurogenesis persists in restricted regions of the adult vertebrate brain. The largest region of adult neurogenesis is the subventricular zone (SVZ) of the lateral ventricle wall. Neural stem cells reside in the SVZ. The SVZ cell types and…
View article: Continuous bronchoscopy during exercise in a pediatric patient: A case report
Continuous bronchoscopy during exercise in a pediatric patient: A case report Open
Exercise‐induced respiratory symptoms limit physical activity and sport performance in adolescents. Etiologies include exercise‐induced bronchoconstriction, laryngeal obstruction, dysfunctional breathing, and in rarer cases, large airway o…
View article: Structural basis for the function of long noncoding RNA <i>Pnky</i> in neural stem cells
Structural basis for the function of long noncoding RNA <i>Pnky</i> in neural stem cells Open
SUMMARY LncRNA Pnky is a trans -acting regulator of neural stem cell (NSC) differentiation, but the molecular mechanisms by which Pnky regulates neurogenesis is unknown. A fundamental step towards mechanistic understanding is to determine …
View article: Transient postoperative femoral neuropathy following prone positioning for posterior spine surgery: illustrative case
Transient postoperative femoral neuropathy following prone positioning for posterior spine surgery: illustrative case Open
BACKGROUND Neurological deficits are a concern following spine surgeries. Determining the etiology is critical as this dictates management options. The authors present the case of a transient bilateral femoral neuropathy following prone po…
View article: Nucleotide GPT: Sequence-Based Deep Learning Prediction of Nuclear Subcompartment-Associated Genome Architecture
Nucleotide GPT: Sequence-Based Deep Learning Prediction of Nuclear Subcompartment-Associated Genome Architecture Open
The spatial organization of the genome within the nucleus is partially determined by its interactions with distinct nuclear subcompartments, such as the nuclear lamina and nuclear speckles, which play key roles in gene regulation during de…
View article: Substructure and maturation of lamina-associated domains in neurons of the developing and adult human brain
Substructure and maturation of lamina-associated domains in neurons of the developing and adult human brain Open
Summary Approximately 30-40% of the human genome is anchored to the nuclear lamina (NL) through variably sized (10 kb-10 Mb) lamina-associated domains (LADs), which can be classified into two subtypes (T1 and T2) based on their level of la…
View article: Spatial 3D genome organization controls the activity of bivalent chromatin during human neurogenesis
Spatial 3D genome organization controls the activity of bivalent chromatin during human neurogenesis Open
The nuclear genome is spatially organized into a three-dimensional (3D) architecture by physical association of large chromosomal domains with subnuclear compartments including the nuclear lamina at the radial periphery and nuclear speckle…
View article: Neural Stem Cell Relay from B1 to B2 cells in the adult mouse Ventricular-Subventricular Zone
Neural Stem Cell Relay from B1 to B2 cells in the adult mouse Ventricular-Subventricular Zone Open
Summary Neurogenesis and gliogenesis continue in the Ventricular-Subventricular Zone (V-SVZ) of the adult rodent brain. B1 cells are astroglial cells derived from radial glia that function as primary progenitors or neural stem cells (NSCs)…
View article: Deconstructing Intratumoral Heterogeneity through Multiomic and Multiscale Analysis of Serial Sections
Deconstructing Intratumoral Heterogeneity through Multiomic and Multiscale Analysis of Serial Sections Open
Tumors may contain billions of cells, including distinct malignant clones and nonmalignant cell types. Clarifying the evolutionary histories, prevalence, and defining molecular features of these cells is essential for improving clinical ou…
View article: Reviewer #2 (Public Review): Chromatin regulator Kdm6b is required for the establishment and maintenance of neural stem cells in mouse hippocampus
Reviewer #2 (Public Review): Chromatin regulator Kdm6b is required for the establishment and maintenance of neural stem cells in mouse hippocampus Open
Neural stem cells (NSCs) in the mouse hippocampal dentate gyrus (DG) – a structure important to learning and memory – generate new neurons postnatally and throughout adult life. However, the regulators that enable this lifelong neurogenesi…
View article: Chromatin regulator Kdm6b is required for the establishment and maintenance of neural stem cells in mouse hippocampus
Chromatin regulator Kdm6b is required for the establishment and maintenance of neural stem cells in mouse hippocampus Open
Neural stem cells (NSCs) in the mouse hippocampal dentate gyrus (DG) – a structure important to learning and memory – generate new neurons postnatally and throughout adult life. However, the regulators that enable this lifelong neurogenesi…
View article: Reviewer #3 (Public Review): Chromatin regulator Kdm6b is required for the establishment and maintenance of neural stem cells in mouse hippocampus
Reviewer #3 (Public Review): Chromatin regulator Kdm6b is required for the establishment and maintenance of neural stem cells in mouse hippocampus Open
Neural stem cells (NSCs) in the mouse hippocampal dentate gyrus (DG) – a structure important to learning and memory – generate new neurons postnatally and throughout adult life. However, the regulators that enable this lifelong neurogenesi…
View article: Author response: Chromatin regulator Kdm6b is required for the establishment and maintenance of neural stem cells in mouse hippocampus
Author response: Chromatin regulator Kdm6b is required for the establishment and maintenance of neural stem cells in mouse hippocampus Open
Neural stem cells (NSCs) in the mouse hippocampal dentate gyrus (DG) – a structure important to learning and memory – generate new neurons postnatally and throughout adult life. However, the regulators that enable this lifelong neurogenesi…
View article: Chromatin regulator Kdm6b is required for the establishment and maintenance of neural stem cells in mouse hippocampus
Chromatin regulator Kdm6b is required for the establishment and maintenance of neural stem cells in mouse hippocampus Open
Neural stem cells (NSCs) in the mouse hippocampal dentate gyrus (DG) – a structure important to learning and memory – generate new neurons postnatally and throughout adult life. However, the regulators that enable this lifelong neurogenesi…
View article: Reviewer #1 (Public Review): Chromatin regulator Kdm6b is required for the establishment and maintenance of neural stem cells in mouse hippocampus
Reviewer #1 (Public Review): Chromatin regulator Kdm6b is required for the establishment and maintenance of neural stem cells in mouse hippocampus Open
Neural stem cells (NSCs) in the mouse hippocampal dentate gyrus (DG) – a structure important to learning and memory – generate new neurons postnatally and throughout adult life. However, the regulators that enable this lifelong neurogenesi…
View article: Chromatin regulator <i>Kdm6b</i> is required for the establishment and maintenance of neural stem cells in mouse hippocampus
Chromatin regulator <i>Kdm6b</i> is required for the establishment and maintenance of neural stem cells in mouse hippocampus Open
Neural stem cells (NSCs) in the mouse hippocampal dentate gyrus (DG) – a structure important to learning and memory – generate new neurons postnatally and throughout adult life. However, the regulators that enable this lifelong neurogenesi…
View article: Epigenetic reprogramming shapes the cellular landscape of schwannoma
Epigenetic reprogramming shapes the cellular landscape of schwannoma Open
Mechanisms specifying cancer cell states and response to therapy are incompletely understood. Here we show epigenetic reprogramming shapes the cellular landscape of schwannomas, the most common tumors of the peripheral nervous system. We f…
View article: Sex-specific role for the long noncoding RNA<i>Pnky</i>in mouse behavior
Sex-specific role for the long noncoding RNA<i>Pnky</i>in mouse behavior Open
SUMMARY The human brain expresses thousands of different long noncoding RNAs (lncRNAs), and aberrant expression of specific lncRNAs has been associated with cognitive and psychiatric disorders. While a growing number of lncRNAs are now kno…
View article: EPCO-12. <i>IN VIVO</i> PERTURB-SEQ DEFINES BIOLOGICAL DRIVERS AND THERAPEUTIC VULNERABILITIES UNDERLYING RADIOTHERAPY RESISTANCE IN GLIOBLASTOMA
EPCO-12. <i>IN VIVO</i> PERTURB-SEQ DEFINES BIOLOGICAL DRIVERS AND THERAPEUTIC VULNERABILITIES UNDERLYING RADIOTHERAPY RESISTANCE IN GLIOBLASTOMA Open
Glioblastomas are comprised of dynamic malignant cell states and microenvironment cell types. Mechanistic and functional studies of glioblastoma resistance to therapy have been limited by a lack of in vivo approaches for multiplexed interr…
View article: EPCO-39. CLARIFYING THE MOLECULAR CONSEQUENCES OF ONCOGENIC MUTATIONS THROUGH MULTISCALE AND MULTIOMIC ANALYSIS OF INDIVIDUAL TUMORS
EPCO-39. CLARIFYING THE MOLECULAR CONSEQUENCES OF ONCOGENIC MUTATIONS THROUGH MULTISCALE AND MULTIOMIC ANALYSIS OF INDIVIDUAL TUMORS Open
Understanding the molecular consequences of oncogenic mutations is an important goal that may reveal essential features of malignant cells and new therapeutic targets for diverse cancers. However, this task is complicated by substantial in…
View article: In vivo perturb-seq of cancer and microenvironment cells dissects oncologic drivers and radiotherapy responses in glioblastoma
In vivo perturb-seq of cancer and microenvironment cells dissects oncologic drivers and radiotherapy responses in glioblastoma Open
Genetic perturbation screens with single cell readouts have enabled rich phenotyping of gene function and regulatory networks. These approaches have been challenging in vivo, especially in adult disease models such as cancer, which include…
View article: Deconstructing intratumoral heterogeneity through multiomic and multiscale analysis of serial sections
Deconstructing intratumoral heterogeneity through multiomic and multiscale analysis of serial sections Open
Tumors may contain billions of cells including distinct malignant clones and nonmalignant cell types. Clarifying the evolutionary histories, prevalence, and defining molecular features of these cells is essential for improving clinical out…
View article: Epigenetic reprogramming shapes the cellular landscape of schwannoma
Epigenetic reprogramming shapes the cellular landscape of schwannoma Open
Summary Cell state evolution underlies tumor development and response to therapy 1 , but mechanisms specifying cancer cell states and intratumor heterogeneity are incompletely understood. Schwannomas are the most common tumors of the perip…
View article: Conserved and Distinct Functions of the Autism-Related Chromatin Remodeler CHD8 in Embryonic and Adult Forebrain Neurogenesis
Conserved and Distinct Functions of the Autism-Related Chromatin Remodeler CHD8 in Embryonic and Adult Forebrain Neurogenesis Open
The chromatin remodeler CHD8 represents a high-confidence risk factor in autism, a multistage progressive neurologic disorder, however the underlying stage-specific functions remain elusive. In this study, by analyzing Chd8 conditional kno…