Daniel A. Oakes
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View article: Validation of non-invasive methods for the measurement of gonadal and inter-renal steroid hormones in a desert-adapted amphibian (<i>Scaphiopus couchii</i>)
Validation of non-invasive methods for the measurement of gonadal and inter-renal steroid hormones in a desert-adapted amphibian (<i>Scaphiopus couchii</i>) Open
For aquatic and semi-aquatic vertebrates like amphibians, it is possible to estimate excreted hormone levels using non-invasive methods such as waterborne and salivary sampling. These techniques allow monitoring of endocrine activity over …
View article: Cemented Constrained Liners Used as an Articulating Hip Spacer for the Treatment of Chronic Prosthetic Joint Infection
Cemented Constrained Liners Used as an Articulating Hip Spacer for the Treatment of Chronic Prosthetic Joint Infection Open
Utilization of a constrained liner as an articulating spacer is a viable option for patients at high risk of instability. Meticulous cement technique, appropriate component position, and implant selection are crucial in achieving successfu…
View article: Fracture of the Proximal Body of a Modern Cementless Modular Fluted Tapered Stem
Fracture of the Proximal Body of a Modern Cementless Modular Fluted Tapered Stem Open
Previous reports have described failures of modular fluted tapered femoral stems secondary to fatigue failure at the modular junction. However, the present study is the first reported case of modular fluted tapered femoral component failur…
View article: Phase 1 study of the pharmacokinetics and clinical proof-of-concept activity of a biofilm-disrupting human monoclonal antibody in patients with chronic prosthetic joint infection of the knee or hip
Phase 1 study of the pharmacokinetics and clinical proof-of-concept activity of a biofilm-disrupting human monoclonal antibody in patients with chronic prosthetic joint infection of the knee or hip Open
We report the results of a first-in-human phase 1 clinical study to evaluate TRL1068, a native human monoclonal antibody that disrupts bacterial biofilms with broad-spectrum activity against both Gram-positive and Gram-negative species. Th…
View article: Robotic-Assisted Total Knee Arthroplasty in Obese Patients
Robotic-Assisted Total Knee Arthroplasty in Obese Patients Open
Obese patients treated with robotic-assisted TKA had postoperative alignment closer to neutral and fewer postoperative radiographic outliers than patients treated with conventional instrumentation. The results of this study support use of …
View article: Postoperative Complications Associated with Non-Steroidal Anti-Inflammatory Combinations Used Status-Post Total Hip and Knee Arthroplasty
Postoperative Complications Associated with Non-Steroidal Anti-Inflammatory Combinations Used Status-Post Total Hip and Knee Arthroplasty Open
Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used in multimodal pain control following total joint arthroplasty (TJA). However, few studies have assessed the complications associated with the combinations of NSAIDs in this p…
View article: A double-blinded, placebo-controlled, randomized study to evaluate the efficacy of perioperative dextromethorphan compared to placebo for the treatment of postoperative pain: a study protocol
A double-blinded, placebo-controlled, randomized study to evaluate the efficacy of perioperative dextromethorphan compared to placebo for the treatment of postoperative pain: a study protocol Open
Background Pain management is a critical component of comprehensive postsurgical care, as it influences patient safety and outcomes, and inadequate control has been associated with the development of chronic pain syndromes. Despite recent …
View article: Drill Bone with Both Hands: Plunge Depth and Accuracy with 4 Bracing Positions
Drill Bone with Both Hands: Plunge Depth and Accuracy with 4 Bracing Positions Open
Introduction: Bone drilling is a critical skill honed during orthopaedic surgical education. How a bone drill is held and operated (bracing position) may influence drilling performance. Methods: A prospective study with randomized crossove…
View article: Regional Gene Therapy with Transduced Human Cells: The Influence of “Cell Dose” on Bone Repair
Regional Gene Therapy with Transduced Human Cells: The Influence of “Cell Dose” on Bone Repair Open
Regional gene therapy using a lentiviral vector containing the BMP-2 complementary DNA (cDNA) has been shown to heal critical-sized bone defects in rodent models. An appropriate "cellular dose" needs to be defined for eventual translation …
View article: Trends in computer navigation and robotic assistance for total knee arthroplasty in the United States: an analysis of patient and hospital factors
Trends in computer navigation and robotic assistance for total knee arthroplasty in the United States: an analysis of patient and hospital factors Open
The use of computer navigation and robot-assisted TKA steadily increased over the study period, accounting for 7.0% of TKAs performed in the United States in 2014. Marked regional differences in the use of these technologies were identifie…
View article: Complex Reconstruction of the Knee with a Free Vertical Rectus Abdominis Flap after Periprosthetic Soft Tissue Necrosis
Complex Reconstruction of the Knee with a Free Vertical Rectus Abdominis Flap after Periprosthetic Soft Tissue Necrosis Open
Periprosthetic joint infection (PJI) is limb threatening and difficult to treat. Although a two-stage re-implantation is accepted as the standard of care for PJI, extensive debridement, numerous surgeries, or liquifactive necrosis from the…
View article: Gene Therapy for Bone Repair Using Human Cells: Superior Osteogenic Potential of <i>Bone Morphogenetic Protein 2</i> –Transduced Mesenchymal Stem Cells Derived from Adipose Tissue Compared to Bone Marrow
Gene Therapy for Bone Repair Using Human Cells: Superior Osteogenic Potential of <i>Bone Morphogenetic Protein 2</i> –Transduced Mesenchymal Stem Cells Derived from Adipose Tissue Compared to Bone Marrow Open
Ex vivo regional gene therapy strategies using animal mesenchymal stem cells genetically modified to overexpress osteoinductive growth factors have been successfully used in a variety of animal models to induce both heterotopic and orthoto…