Daniel A. Patten
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View article: Secreted Clever-1 modulates T cell responses and impacts cancer immunotherapy efficacy
Secreted Clever-1 modulates T cell responses and impacts cancer immunotherapy efficacy Open
Rationale: Clever-1 is a multifunctional scavenger receptor that promotes immunosuppressive activity in macrophages, contributing to tumor immune evasion. Its high expression correlates with resistance to immune checkpoint inhibitor…
View article: Regulatory T cell stability determines the efficiency of bile duct regeneration during cholangitis
Regulatory T cell stability determines the efficiency of bile duct regeneration during cholangitis Open
Background and Aims Cholangiopathies such as Primary Sclerosing Cholangitis (PSC) cause damage to the bile ducts and fibrosis with no effective cure. A reduction and impairment in the function of regulatory T cells (Tregs) occurs in PSC. Y…
View article: Differential expression of endothelial derived galectins in response to shear stress
Differential expression of endothelial derived galectins in response to shear stress Open
View article: Regulatory T Cell Stability Determines the Efficiency of Bile Duct Regeneration During Cholangitis
Regulatory T Cell Stability Determines the Efficiency of Bile Duct Regeneration During Cholangitis Open
View article: The Role of Macrophages in Hepatocellular Carcinoma and Their Therapeutic Potential
The Role of Macrophages in Hepatocellular Carcinoma and Their Therapeutic Potential Open
Hepatocellular carcinoma (HCC) represents a significant clinical burden globally and is predicted to continue to increase in incidence for the foreseeable future. The treatment of HCC is complicated by the fact that, in the majority of cas…
View article: Protocol to study monocyte transmigration across primary human liver endothelial cells under physiological shear flow conditions in vitro
Protocol to study monocyte transmigration across primary human liver endothelial cells under physiological shear flow conditions in vitro Open
View article: Secreted Clever-1 Modulates T Cell Responses and Impacts Cancer Immunotherapy Efficacy
Secreted Clever-1 Modulates T Cell Responses and Impacts Cancer Immunotherapy Efficacy Open
Clever-1 functions as a scavenger and adhesion receptor, promoting tolerogenic activities in macrophages and subsets of endothelial cells, thereby contributing to cancer progression. High Clever-1 expression associates with resistance to i…
View article: Expression of E-cadherin by CD8+ T cells promotes their invasion into biliary epithelial cells
Expression of E-cadherin by CD8+ T cells promotes their invasion into biliary epithelial cells Open
View article: The senescent secretome drives PLVAP expression in cultured human hepatic endothelial cells to promote monocyte transmigration
The senescent secretome drives PLVAP expression in cultured human hepatic endothelial cells to promote monocyte transmigration Open
Liver sinusoidal endothelial cells (LSEC) undergo significant phenotypic change in chronic liver disease (CLD), and yet the factors that drive this process and the impact on their function as a vascular barrier and gatekeeper for immune ce…
View article: PDGFRα/Sca-1 Sorted Mesenchymal Stromal Cells Reduce Liver Injury in Murine Models of Hepatic Ischemia-Reperfusion Injury
PDGFRα/Sca-1 Sorted Mesenchymal Stromal Cells Reduce Liver Injury in Murine Models of Hepatic Ischemia-Reperfusion Injury Open
Liver transplantation is an effective therapy, but increasing demand for donor organs has led to the use of marginal donor organs with increased complication rates. Mesenchymal stromal cells (MSC) pleiotropically modulate aberrant immune-m…
View article: Senescence-induced endothelial phenotypes underpin immune-mediated senescence surveillance
Senescence-induced endothelial phenotypes underpin immune-mediated senescence surveillance Open
Senescence is a stress-responsive tumor suppressor mechanism associated with expression of the senescence-associated secretory phenotype (SASP). Through the SASP, senescent cells trigger their own immune-mediated elimination, which if evad…
View article: Erratum to: Scavenger Receptors: Novel Roles in the Pathogenesis of Liver Inflammation and Cancer
Erratum to: Scavenger Receptors: Novel Roles in the Pathogenesis of Liver Inflammation and Cancer Open
Correction to: Scavenger Receptors: Novel Roles in the Pathogenesis of Liver Inflammation and CancerSemin Liver Dis 2022; 42(01): 061-076DOI: 10.1055/s-0041-1733876
View article: A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma Open
The aggressiveness and lack of well-tolerated and widely effective treatments for advanced hepatocellular carcinoma (HCC), the predominant form of liver cancer, rationalize its rank as the second most common cause of cancer-related death. …
View article: A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma Open
The aggressiveness and lack of well-tolerated and widely effective treatments for advanced hepatocellular carcinoma (HCC), the predominant form of liver cancer, rationalize its rank as the second most common cause of cancer-related death. …
View article: Scavenger Receptors: Novel Roles in the Pathogenesis of Liver Inflammation and Cancer
Scavenger Receptors: Novel Roles in the Pathogenesis of Liver Inflammation and Cancer Open
The scavenger receptor superfamily represents a highly diverse collection of evolutionarily-conserved receptors which are known to play key roles in host homeostasis, the most prominent of which is the clearance of unwanted endogenous macr…
View article: O02 Deep sequencing of HCC endothelium reveals an active role in immunosuppression and highlights the ecto nucleotidase CD73 as a potential therapeutic target
O02 Deep sequencing of HCC endothelium reveals an active role in immunosuppression and highlights the ecto nucleotidase CD73 as a potential therapeutic target Open
Introduction Overcoming the immunosuppressive microenvironment in HCC is a major challenge. Better understanding of the cell specific contribution is required to help boost current immunotherapy. Endothelial cells are the gatekeeper for im…
View article: P029 Plasmalemma vesicle-associated protein (PLVAP) mediates monocyte transmigration across human hepatic sinusoidal endothelium in response to the senescent secretome
P029 Plasmalemma vesicle-associated protein (PLVAP) mediates monocyte transmigration across human hepatic sinusoidal endothelium in response to the senescent secretome Open
Senescence is an autonomous state of cell cycle arrest which is an important mechanism preventing malignant transformation. Recent evidence suggests that cellular senescence may also have a double-edged effect, contributing to chronic liv…
View article: Exploring the prognostic value of SCARF1 in non-small cell lung cancers
Exploring the prognostic value of SCARF1 in non-small cell lung cancers Open
Scavenger receptor class F member 1 (SCARF1) has previously been shown to be highly expressed within the human liver, hold prognostic value in hepatocellular carcinoma and mediate the specific recruitment of leukocytes to liver sinusoidal …
View article: Prognostic Value and Potential Immunoregulatory Role of SCARF1 in Hepatocellular Carcinoma
Prognostic Value and Potential Immunoregulatory Role of SCARF1 in Hepatocellular Carcinoma Open
Scavenger receptor class F member 1 (SCARF1) is thought to play an important role in the selective recruitment of CD4+ T cells to liver sinusoidal endothelial cells during chronic liver disease. However, the contribution of SCAR…
View article: P61 Transcriptomic analysis of endothelium from human hepatocellular carcinoma highlights its potential to suppress anti-tumour immune responses
P61 Transcriptomic analysis of endothelium from human hepatocellular carcinoma highlights its potential to suppress anti-tumour immune responses Open
Promising outcomes with recent immune checkpoint inhibitor trials in hepatocellular carcinoma (HCC) have encouraged the search for novel immunotherapies. The tumour microenvironment in hepatocellular carcinoma (HCC) is highly complex but …
View article: P62 Prognostic value and potential immunoregulatory role of SCARF1 in hepatocellular carcinoma
P62 Prognostic value and potential immunoregulatory role of SCARF1 in hepatocellular carcinoma Open
The immune microenvironment plays a key role in determining the pathogenesis and progression of hepatocellular carcinoma (HCC). Some immune cell subsets promote tumour growth whilst others drive anti-tumour responses. Elucidating the mech…
View article: P83 Mannose receptor (MR) and plasmalemma vesicle-associated protein (PLVAP) are differentially regulated in the hepatic sinusoids: understanding the impact on liver inflammation
P83 Mannose receptor (MR) and plasmalemma vesicle-associated protein (PLVAP) are differentially regulated in the hepatic sinusoids: understanding the impact on liver inflammation Open
Chronic liver diseases (CLDs) are characterised by leukocyte infiltration which drives chronic inflammation, fibrosis and cirrhosis. Hepatic sinusoidal endothelial cells (HSEC) play a critical role in liver homeostasis, regulating the imm…
View article: The platelet receptor CLEC-2 blocks neutrophil mediated hepatic recovery in acetaminophen induced acute liver failure
The platelet receptor CLEC-2 blocks neutrophil mediated hepatic recovery in acetaminophen induced acute liver failure Open
Acetaminophen (APAP) is the main cause of acute liver failure in the West. Specific efficacious therapies for acute liver failure (ALF) are limited and time-dependent. The mechanisms that drive irreversible acute liver failure remain poorl…
View article: The Role of Stabilin-1 in Lymphocyte Trafficking and Macrophage Scavenging in the Liver Microenvironment
The Role of Stabilin-1 in Lymphocyte Trafficking and Macrophage Scavenging in the Liver Microenvironment Open
Chronic liver diseases are a major global health burden, and cases of these conditions continue to rise in many countries. A diverse range of insults can lead to chronic liver disease, but they are all characterised by the infiltration and…
View article: Tumour-associated macrophages in hepatocellular carcinoma: Pressing the metabolic switch to prevent T cell responses
Tumour-associated macrophages in hepatocellular carcinoma: Pressing the metabolic switch to prevent T cell responses Open
View article: Novel Targets in the Immune Microenvironment of the Hepatic Sinusoids for Treating Liver Diseases
Novel Targets in the Immune Microenvironment of the Hepatic Sinusoids for Treating Liver Diseases Open
Immune dysregulation and accumulation of leukocytes is a hallmark of adult chronic liver diseases. Progressive hepatic inflammation can lead to fibrosis and cirrhosis with a high risk of liver failure or hepatocellular cancer (HCC). Recent…
View article: More Than Just a Removal Service: Scavenger Receptors in Leukocyte Trafficking
More Than Just a Removal Service: Scavenger Receptors in Leukocyte Trafficking Open
Scavenger receptors are a highly diverse superfamily of proteins which are grouped by their inherent ability to bind and internalize a wide array of structurally diverse ligands which can be either endogenous or exogenous in nature. Conseq…
View article: SCARF1: a multifaceted, yet largely understudied, scavenger receptor
SCARF1: a multifaceted, yet largely understudied, scavenger receptor Open
This review summarises our current knowledge on SCARF1 biology and reflects on future directions for research on this multifaceted, yet largely understudied, scavenger receptor.
View article: SCARF-1 promotes adhesion of CD4+ T cells to human hepatic sinusoidal endothelium under conditions of shear stress
SCARF-1 promotes adhesion of CD4+ T cells to human hepatic sinusoidal endothelium under conditions of shear stress Open