Daniel Adekunbi
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View article: Sex-specific decline in prefrontal cortex mitochondrial bioenergetics in aging baboons correlates with walking speed
Sex-specific decline in prefrontal cortex mitochondrial bioenergetics in aging baboons correlates with walking speed Open
Mitochondria play a crucial role in brain aging due to their involvement in bioenergetics, neuroinflammation and brain steroid synthesis. Mitochondrial dysfunction is linked to age-related neurodegenerative diseases, including Alzheimer’s …
View article: Perinatal maternal undernutrition in baboons modulates hepatic mitochondrial function but not metabolites in aging offspring
Perinatal maternal undernutrition in baboons modulates hepatic mitochondrial function but not metabolites in aging offspring Open
We previously demonstrated in baboons that maternal undernutrition (MUN), achieved by 70 % of control nutrition, impairs fetal liver function, but long-term changes associated with aging in this model remain unexplored. Here, we assessed c…
View article: Differential mitochondrial bioenergetics and cellular resilience in astrocytes, hepatocytes, and fibroblasts from aging baboons
Differential mitochondrial bioenergetics and cellular resilience in astrocytes, hepatocytes, and fibroblasts from aging baboons Open
Biological resilience, broadly defined as ability to recover from acute challenge and return to homeostasis, is of growing importance to the biology of aging. At the cellular level, there is variability across tissue types in resilience an…
View article: CELLULAR RESILIENCE AND THE AGING HEART: UNDERSTANDING MITOCHONDRIAL INJURY MECHANISMS USING THE BABOON
CELLULAR RESILIENCE AND THE AGING HEART: UNDERSTANDING MITOCHONDRIAL INJURY MECHANISMS USING THE BABOON Open
Background Aging-related cardiovascular disease is deadly worldwide. Cardiac aging in non-human primates (NHP), including baboons, is similar to humans, and intrauterine growth restriction animal models (IUGR) have shown to accelerate card…
View article: SEX DIFFERENCES IN MITOCHONDRIAL RESILIENCE: EVIDENCE FROM BABOON HEPATOCYTES
SEX DIFFERENCES IN MITOCHONDRIAL RESILIENCE: EVIDENCE FROM BABOON HEPATOCYTES Open
Events that occur in utero set the trajectory for later-life diseases and longevity. Compelling data exist for interactions between developmental programming and aging, but the underlying mechanisms are not clearly defined. Fetal exposure …
View article: CLARIFYING THE ROLE OF RESILIENCE IN NONHUMAN PRIMATE AGING USING A BABOON CELL MODEL
CLARIFYING THE ROLE OF RESILIENCE IN NONHUMAN PRIMATE AGING USING A BABOON CELL MODEL Open
Aging is associated with defects in homeostatic maintenance. Delineating the dynamics of the homeostatic network is challenging in vivo and often limited by endpoint measurements. However, we have developed carefully controlled translatabl…
View article: CELLULAR RESPIRATION AND RESILIENCE AS A POTENTIAL BIOLOGICAL MECHANISM DRIVING SEX DIFFERENCES IN AGING
CELLULAR RESPIRATION AND RESILIENCE AS A POTENTIAL BIOLOGICAL MECHANISM DRIVING SEX DIFFERENCES IN AGING Open
There are substantial differences in the progression of aging between males and females including in progression and prevalence of disease and longevity. Not all can be explained solely by sex-specific endocrine regulation and growing evid…
View article: Cellular resilience and baboon aging
Cellular resilience and baboon aging Open
Figure 1.Cellular proliferation responses to homeostatic challenges in primary skin-derived Baboon fibroblasts.Overview of baboon cell culture model developed to determine cellular resilience to homeostatic challenges.Representative data s…
View article: Differential impact of maternal overnutrition and undernutrition on offspring glucose homeostasis
Differential impact of maternal overnutrition and undernutrition on offspring glucose homeostasis Open
To test the hypothesis that maternal undernutrition exerts a greater effect on offspring metabolic function compared to maternal overnutrition, female rats (n=10 per group) were subjected to a high calorie diet or 50 % global nutrient rest…
View article: Testing Cellular Proliferation Responses to Oxidative, Glucocorticoid and Metabolic Challenges in the Baboon
Testing Cellular Proliferation Responses to Oxidative, Glucocorticoid and Metabolic Challenges in the Baboon Open
Aging is associated with progressive loss of cellular homeostasis which results from intrinsic and extrinsic challenges. Testing how such challenges relate to the aging process is often limited by the available model systems. We use primar…
View article: Role of the posterodorsal medial amygdala in predator odour stress‐induced puberty delay in female rats
Role of the posterodorsal medial amygdala in predator odour stress‐induced puberty delay in female rats Open
Puberty onset is influenced by various factors, including psychosocial stress. The present study investigated cat‐odour stress on puberty onset and oestrous cyclicity in rats. Female weanling rats were exposed to either soiled cat litter o…
View article: Kisspeptin neurones in the posterodorsal medial amygdala modulate sexual partner preference and anxiety in male mice
Kisspeptin neurones in the posterodorsal medial amygdala modulate sexual partner preference and anxiety in male mice Open
The posterodorsal medial amygdala (MePD) is a neural site in the limbic brain involved in regulating emotional and sexual behaviours. There is, however, limited information available on the specific neuronal cell type in the MePD functiona…
View article: Magnesium upregulates insulin receptor and glucose transporter-4 in streptozotocin-nicotinamide-induced type-2 diabetic rats
Magnesium upregulates insulin receptor and glucose transporter-4 in streptozotocin-nicotinamide-induced type-2 diabetic rats Open
Objective. We investigated the effects of magnesium supplementation on glucose tolerance, insulin sensitivity, oxidative stress as well as the concentration of insulin receptor and glucose transporter-4 in streptozotocin-nicotinamide induc…
View article: Role of amygdala kisspeptin in pubertal timing in female rats
Role of amygdala kisspeptin in pubertal timing in female rats Open
To investigate the mechanism by which maternal obesity disrupts reproductive function in offspring, we examined Kiss1 expression in the hypothalamic arcuate (ARC) and anteroventral periventricular (AVPV) nuclei, and posterodorsal medial am…
View article: Hypothalamic effects of progesterone on regulation of the pulsatile and surge release of luteinising hormone in female rats
Hypothalamic effects of progesterone on regulation of the pulsatile and surge release of luteinising hormone in female rats Open
Progesterone can block the oestradiol-induced GnRH/LH surge and inhibit LH pulse frequency. Recent studies reported that progesterone prevented premature LH surges during ovarian hyperstimulation in women. As the most potent stimulator of …
View article: Kisspeptin in the medial amygdala and sexual behavior in male rats
Kisspeptin in the medial amygdala and sexual behavior in male rats Open
The medial amygdala (MeA) is crucial for sexual behavior; kisspeptin (Kiss1) also plays a role in sexual function. Kisspeptin receptor (Kiss1r) knockout mice display no sexual behavior. Recently Kiss1 and Kiss1r have been discovered in the…
View article: Consumption of high sucrose and/or high salt diet alters sperm function in male Sprague–Dawley rats
Consumption of high sucrose and/or high salt diet alters sperm function in male Sprague–Dawley rats Open
Diets laden with salt and refined sugar have been implicated in the pathogenesis of diabetes and hypertension. However, few studies have investigated the impact of such diets on reproductive functions, hence, the present study. Male Spragu…
View article: Glucose tolerance, insulin sensitivity and adiponectin level in niacin-treated obese rats
Glucose tolerance, insulin sensitivity and adiponectin level in niacin-treated obese rats Open
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
View article: Niacin improves adiponectin secretion, glucose tolerance and insulin sensitivity in diet-induced obese rats
Niacin improves adiponectin secretion, glucose tolerance and insulin sensitivity in diet-induced obese rats Open
The present study examined the effect of dietary niacin supplementation on fat mass, glucose control, insulin sensitivity, lipid profile, and adiponectin level in diet-induced obese rats. Male Sprague-Dawley rats (n = 21) were initially di…