Daniel Aggio
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View article: Estimation of Health Utility Values for Eosinophilic Granulomatosis With Polyangiitis
Estimation of Health Utility Values for Eosinophilic Granulomatosis With Polyangiitis Open
The findings highlight the substantial HRQoL impact of EGPA across all health states, with a higher perceived impact for the relapse and refractory health states. The public and EGPA patient samples produced consistent ratings. This study …
View article: A qualitative study to explore the patient experience of hypertriglyceridemia-related acute pancreatitis
A qualitative study to explore the patient experience of hypertriglyceridemia-related acute pancreatitis Open
HTG-AP has a substantial symptomatic and HRQoL burden during episodes, which can persist postrecovery. Treatments that reduce the incidence of HTG-AP have potential to improve HRQoL.
View article: 5129 Symptoms and Impacts of Hypertriglyceridemia-related Acute Pancreatitis: A Qualitative Study of the Patient Experience
5129 Symptoms and Impacts of Hypertriglyceridemia-related Acute Pancreatitis: A Qualitative Study of the Patient Experience Open
Disclosure: A. Sikora Kessler: Employee; Self; Ionis Pharmaceuticals Inc.. Stock Owner; Self; Ionis Pharmaceuticals Inc. D.A. Aggio: Other; Self; Daniel Aggio is an employee of Acaster Lloyd Consulting Ltd. and may hold stock or stock opti…
View article: Psychometric Properties of the EQ-5D-5L in Patients with Alopecia Areata
Psychometric Properties of the EQ-5D-5L in Patients with Alopecia Areata Open
The EQ-5D-5L may not adequately measure the burden of AA on patients' HRQL. Insensitivity to the burden of AA suggests that the EQ-5D-5L may not measure treatment-related benefit with hair regrowth. Data from other measures could be consid…
View article: Estimation of health utility values for alopecia areata
Estimation of health utility values for alopecia areata Open
Purpose Alopecia areata (AA) is an autoimmune-mediated inflammatory dermatological disease characterised by non-scarring hair loss affecting the scalp and sometimes other hair-bearing sites. This study aimed to elicit health state utility …
View article: Estimating utility values for non-alcoholic steatohepatitis health states: a discrete choice experiment
Estimating utility values for non-alcoholic steatohepatitis health states: a discrete choice experiment Open
Background: This study estimated utility values for non-alcoholic steatohepatitis (NASH). Previous studies have assumed that health-related quality of life does not vary between the early stages of NASH. Materials & Methods: Discrete choic…
View article: P1599: REAL-WORLD CLINICAL PRACTICES IN TREATMENT DISCONTINUATION WITH COMPLEMENT C5 INHIBITORS FOR ATYPICAL HEMOLYTIC UREMIC SYNDROME: A GLOBAL SURVEY OF HEALTHCARE PROFESSIONALS
P1599: REAL-WORLD CLINICAL PRACTICES IN TREATMENT DISCONTINUATION WITH COMPLEMENT C5 INHIBITORS FOR ATYPICAL HEMOLYTIC UREMIC SYNDROME: A GLOBAL SURVEY OF HEALTHCARE PROFESSIONALS Open
Topic: 32. Platelet disorders Background: Atypical hemolytic uremic syndrome (aHUS) is a rare disease characterized by hemolytic anemia, thrombocytopenia and organ damage. Ravulizumab (RAV) and eculizumab (ECU) are complement C5 inhibitors…
View article: Estimation of Health Utility Scores for Glycogen Storage Disease Type Ia
Estimation of Health Utility Scores for Glycogen Storage Disease Type Ia Open
This study found an HRQoL burden on GSDIa patients and caregivers, with potential large improvement from a hypothetical treatment. These findings may be useful for families, clinicians, regulatory agencies, and in therapy economic evaluati…
View article: Patient Preferences for Advanced Hepatocellular Carcinoma Treatment: A Multicountry Stated Preference Study
Patient Preferences for Advanced Hepatocellular Carcinoma Treatment: A Multicountry Stated Preference Study Open
The present study aimed to explore patient preferences for attributes of advanced hepatocellular carcinoma (HCC) treatments. A stated preference survey was completed by 150 patients with HCC living in Europe. Overall survival (OS) was the …
View article: Estimation of the Quality-of-Life Impact of X-Linked Myotubular Myopathy
Estimation of the Quality-of-Life Impact of X-Linked Myotubular Myopathy Open
X-linked myotubular myopathy (XLMTM) is a rare, severe, neuromuscular disorder for which novel treatments are under investigation. This study estimated quality-of-life weights (or utilities) for children with XLMTM. The state that was rate…
View article: Utility Values Associated with Atypical Hemolytic Uremic Syndrome-Related Attributes: A Discrete Choice Experiment in Five Countries
Utility Values Associated with Atypical Hemolytic Uremic Syndrome-Related Attributes: A Discrete Choice Experiment in Five Countries Open
Although all attributes played a role in determining treatment preferences, the largest drivers were life expectancy and risk of kidney impairment. Participants favored 8-weekly dosing (corresponding to ravulizumab administration frequency…
View article: Trajectories of physical activity from midlife to old age and associations with subsequent cardiovascular disease and all-cause mortality
Trajectories of physical activity from midlife to old age and associations with subsequent cardiovascular disease and all-cause mortality Open
Introduction It is well established that physical activity (PA) protects against mortality and morbidity, but how long-term patterns of PA are associated with mortality and cardiovascular disease (CVD) remains unclear. Methods 3231 men rec…
View article: Twenty-Year Trajectories of Physical Activity Types from Midlife to Old Age
Twenty-Year Trajectories of Physical Activity Types from Midlife to Old Age Open
Purpose Correlates of physical activity (PA) vary according to type. However, predictors of long-term patterns of PA types into old age are unknown. This study aimed to identify 20-yr trajectories of PA types into old age and their predict…
View article: Association Between 20-Year Trajectories of Nonoccupational Physical Activity From Midlife to Old Age and Biomarkers of Cardiovascular Disease: A 20-Year Longitudinal Study of British Men
Association Between 20-Year Trajectories of Nonoccupational Physical Activity From Midlife to Old Age and Biomarkers of Cardiovascular Disease: A 20-Year Longitudinal Study of British Men Open
The trajectories of physical activity (PA) from midlife into old age and their associations with established and novel cardiovascular disease (CVD) risk factors in later life remain unclear. This study examined associations between 20-year…
View article: Early life cognitive function and health behaviours in late childhood: testing the neuroselection hypothesis
Early life cognitive function and health behaviours in late childhood: testing the neuroselection hypothesis Open
Background Higher cognitive function in childhood is associated with healthier behaviours and a reduced risk of chronic disease in adulthood, but it is unclear whether this selection of healthier behaviours occurs in childhood or later in …
View article: Prospective associations between measures of gross and fine motor coordination in infants and objectively measured physical activity and sedentary behavior in childhood
Prospective associations between measures of gross and fine motor coordination in infants and objectively measured physical activity and sedentary behavior in childhood Open
One important determinant of childhood physical activity and sedentary behavior may be that of motor development in infancy. The present analyses aimed to investigate whether gross and fine motor delays in infants were associated with obje…
View article: Association between physical activity levels in mid-life with physical activity in old age: a 20-year tracking study in a prospective cohort
Association between physical activity levels in mid-life with physical activity in old age: a 20-year tracking study in a prospective cohort Open
Objectives This study aims to examine the tracking and predictability of physical activity in old age from overall physical activity and participation in sport, recreational activity and walking in mid-life. Design Prospective population-b…
View article: Objectively Measured Daily Physical Activity and Postural Changes as Related to Positive and Negative Affect Using Ambulatory Monitoring Assessments
Objectively Measured Daily Physical Activity and Postural Changes as Related to Positive and Negative Affect Using Ambulatory Monitoring Assessments Open
Objective The aim of the study was to determine whether objectively measured daily physical activity and posture of sitting, standing, and sit-to-stand transitions are associated with daily assessments of affect. Methods Participants ( N =…
View article: Longitudinal patterns in objective physical activity and sedentary time in a multi‐ethnic sample of children from the UK
Longitudinal patterns in objective physical activity and sedentary time in a multi‐ethnic sample of children from the UK Open
Summary Background Children of South Asian decent born in the UK display lower levels of physical activity than British Caucasians although no longitudinal data are available. Objectives We aimed to investigate change in activity levels ov…
View article: Context-Specific Associations of Physical Activity and Sedentary Behavior With Cognition in Children
Context-Specific Associations of Physical Activity and Sedentary Behavior With Cognition in Children Open
In the present study, we investigated how overall and specific domains of physical activity and sedentary behavior at the age of 7 years were associated with cognition at the age of 11 years in 8,462 children from the Millennium Cohort Stu…
View article: Aggio et al. Respond to “Lessons for Research on Cognitive Aging”
Aggio et al. Respond to “Lessons for Research on Cognitive Aging” Open
This is an Open Access Article. It is published by Oxford University Press under the Creative Commons Attribution 4.0 Unported Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/