Daniel Aili
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View article: Printing and Rerouting of Elastic and Protease Responsive Shape Memory Hydrogel Filaments
Printing and Rerouting of Elastic and Protease Responsive Shape Memory Hydrogel Filaments Open
The fabrication of mechanically robust and reconfigurable hydrogel filaments remains a major challenge in biofabrication of perfusable architectures, dynamic tissue models, and complex 3D cell‐laden constructs. Conventional extrusion‐based…
View article: Biphasic Granular Bioinks for Biofabrication of High Cell Density Constructs for Dermal Regeneration
Biphasic Granular Bioinks for Biofabrication of High Cell Density Constructs for Dermal Regeneration Open
Chronic wounds and severe skin injuries pose significant clinical challenges, as existing treatments like cultured epidermal autografts and tissue engineering strategies fail to regenerate functional dermal tissue effectively. These method…
View article: Nanocellulose Wound Dressings with Integrated Protease Sensors for Detection of Wound Pathogens
Nanocellulose Wound Dressings with Integrated Protease Sensors for Detection of Wound Pathogens Open
Wound infections result in delayed healing, morbidity, and increased risks of sepsis. Early detection of wound infections can facilitate treatment and reduce the need for the excessive use of antibiotics. Proteases are normally active duri…
View article: Orthogonal conjugation of anchoring-dependent membrane active peptides for tuning of liposome permeability
Orthogonal conjugation of anchoring-dependent membrane active peptides for tuning of liposome permeability Open
Conjugation of designed membrane-active peptides to liposomes via thiol–maleimide and DBCO-based copper-free click chemistry enables triggered release, revealing lipid composition effects on conjugation specificity and release kinetics.
View article: Stress-assisted clustering-triggered emission of cellulose- based materials
Stress-assisted clustering-triggered emission of cellulose- based materials Open
Cellulose-based materials can be classified as non-conventional luminogens that produce photoluminescence (PL) in the visible range due to specific intermolecular arrangements. Usually such an arrangement is referred to as clusterization. …
View article: Self-Assembly of Soft and Conformable Broadband Absorbing Nanocellulose-Gold Nanoparticle Composites
Self-Assembly of Soft and Conformable Broadband Absorbing Nanocellulose-Gold Nanoparticle Composites Open
Broadband light-absorbing materials are of large interest for numerous applications ranging from solar harvesting and photocatalysis to low reflection coatings. Fabrication of these materials is often complex and typically utilizes coating…
View article: Engineering Conductive Hydrogels with Tissue‐like Properties: A 3D Bioprinting and Enzymatic Polymerization Approach
Engineering Conductive Hydrogels with Tissue‐like Properties: A 3D Bioprinting and Enzymatic Polymerization Approach Open
Hydrogels are promising materials for medical devices interfacing with neural tissues due to their similar mechanical properties. Traditional hydrogel‐based bio‐interfaces lack sufficient electrical conductivity, relying on low ionic condu…
View article: In-line fiber optical sensor for detection of IgG aggregates in affinity chromatography
In-line fiber optical sensor for detection of IgG aggregates in affinity chromatography Open
Therapeutic monoclonal antibodies (mAbs) are critical for treatment of a wide range of diseases. Immunoglobulin G (IgG) is the most predominant form of mAb but is prone to aggregation during production. Detection and removal of IgG aggrega…
View article: Enzymatically Triggered Peptide–Lipid Conjugation of Designed Membrane Active Peptides for Controlled Liposomal Release
Enzymatically Triggered Peptide–Lipid Conjugation of Designed Membrane Active Peptides for Controlled Liposomal Release Open
Possibilities for controlling the release of pharmaceuticals from liposomal drug delivery systems can enhance their efficacy and reduce their side effects. Membrane-active peptides (MAPs) can be tailored to promote liposomal release when c…
View article: Self-Assembly of Metal Nanoparticles in Bacterial Cellulose for the Fabrication of Soft Substrate-Supported Catalysts
Self-Assembly of Metal Nanoparticles in Bacterial Cellulose for the Fabrication of Soft Substrate-Supported Catalysts Open
The transition to green and sustainable catalysts necessitates efficient and safe preparation techniques using abundant and renewable resources. Many metal nanoparticles (NPs) are excellent catalysts but suffer from poor colloidal stabilit…
View article: Influence of lipid vesicle properties on the function of conjugation dependent membrane active peptides
Influence of lipid vesicle properties on the function of conjugation dependent membrane active peptides Open
Membrane active peptides (MAPs) can provide novel means to trigger the release of liposome encapsulated drugs to improve the efficacy of liposomal drug delivery systems.
View article: Proteolytic remodeling of 3D bioprinted tumor microenvironments
Proteolytic remodeling of 3D bioprinted tumor microenvironments Open
In native tissue, remodeling of the pericellular space is essential for cellular activities and is mediated by tightly regulated proteases. Protease activity is dysregulated in many diseases, including many forms of cancer. Increased prote…
View article: Preparation and Characterization of Softwood and Hardwood Nanofibril Hydrogels: Toward Wound Dressing Applications
Preparation and Characterization of Softwood and Hardwood Nanofibril Hydrogels: Toward Wound Dressing Applications Open
Hydrogels of cellulose nanofibrils (CNFs) are promising wound dressing candidates due to their biocompatibility, high water absorption, and transparency. Herein, two different commercially available wood species, softwood and hardwood, wer…
View article: Proteolytic Remodeling of 3D Bioprinted Tumor Microenvironments
Proteolytic Remodeling of 3D Bioprinted Tumor Microenvironments Open
In native tissue, remodeling of the pericellular space is essential for cellular activities and is mediated by tightly regulated proteases. Protease activity is dysregulated in many diseases, including many forms of cancer. Increased prote…
View article: Nanocellulose Reinforced Hyaluronan-Based Bioinks
Nanocellulose Reinforced Hyaluronan-Based Bioinks Open
Bioprinting of hydrogel-based bioinks can allow for the fabrication of elaborate, cell-laden 3D structures. In addition to providing an adequate extracellular matrix mimetic environment and high cell viability, the hydrogels must offer fac…
View article: Self-Assembly of Nanocellulose Hydrogels Mimicking Bacterial Cellulose for Wound Dressing Applications
Self-Assembly of Nanocellulose Hydrogels Mimicking Bacterial Cellulose for Wound Dressing Applications Open
The self-assembly of nanocellulose in the form of cellulose nanofibers (CNFs) can be accomplished via hydrogen-bonding assistance into completely bio-based hydrogels. This study aimed to use the intrinsic properties of CNFs, such as their …
View article: Astrocyte 3D culture and bioprinting using peptide functionalized hyaluronan hydrogels
Astrocyte 3D culture and bioprinting using peptide functionalized hyaluronan hydrogels Open
Astrocytes play an important role in the central nervous system, contributing to the development of and maintenance of synapses, recycling of neurotransmitters, and the integrity and function of the blood-brain barrier. Astrocytes are also…
View article: Plantaricin NC8 αβ rapidly and efficiently inhibits flaviviruses and SARS-CoV-2 by disrupting their envelopes
Plantaricin NC8 αβ rapidly and efficiently inhibits flaviviruses and SARS-CoV-2 by disrupting their envelopes Open
Potent broad-spectrum antiviral agents are urgently needed to combat existing and emerging viral infections. This is particularly important considering that vaccine development is a costly and time consuming process and that viruses consta…
View article: Nanoplasmonic Avidity-Based Detection and Quantification of IgG Aggregates
Nanoplasmonic Avidity-Based Detection and Quantification of IgG Aggregates Open
Production of therapeutic monoclonal antibodies (mAbs) is a complex process that requires extensive analytical and bioanalytical characterization to ensure high and consistent product quality. Aggregation of mAbs is common and very problem…
View article: Enzymatically Triggered Deprotection and Cross-Linking of Thiolated Alginate-Based Bioinks
Enzymatically Triggered Deprotection and Cross-Linking of Thiolated Alginate-Based Bioinks Open
Thiolated polymers are widely used in hydrogels for drug delivery, tissue engineering, and biofabrication. The oxidation of thiols is spontaneous, resulting in the formation of disulfide bridges and cross linking of polymers. The cross-lin…
View article: Astrocyte 3D Culture and Bioprinting using Peptide Functionalized Hyaluronan Hydrogels
Astrocyte 3D Culture and Bioprinting using Peptide Functionalized Hyaluronan Hydrogels Open
The often-forgotten astrocytes play an important role in the central nervous system, contributing to the development of and maintenance of synapses, recycling of neurotransmitters, and the pathophysiology of various neurodegenerative disea…