Akingbolabo Daniel Ogunlakin
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View article: Understanding the mechanism of Crassocephalum crepidiodes (Benth.) S. Moore leaf antifibrotic activity using in vivo and in silico methods
Understanding the mechanism of Crassocephalum crepidiodes (Benth.) S. Moore leaf antifibrotic activity using in vivo and in silico methods Open
Approximately 30% of women of reproductive age are affected by uterine leiomyomas (fibroids). In women of reproductive age, these benign tumours have been associated with a higher risk of developing type II diabetes and infertility, which …
View article: Ethnomedicinal validation of Telfairia occidentalis L. leaf: a dual experimental and computational approach to uterine leiomyoma therapy
Ethnomedicinal validation of Telfairia occidentalis L. leaf: a dual experimental and computational approach to uterine leiomyoma therapy Open
Introduction A nutrient-dense vegetable with Ethnomedicinal use for treating oxidative and fibrotic diseases is Telfairia occidentalis L., often known as “ugu” in Nigeria. Although it has been used extensively in the past, neither experime…
View article: Quercetin-3-O-galactoside from Garcinia Kola Heckel stem bark as a potential bioactive inhibitor against histone deacetylase 8 (HDAC8) using in silico study
Quercetin-3-O-galactoside from Garcinia Kola Heckel stem bark as a potential bioactive inhibitor against histone deacetylase 8 (HDAC8) using in silico study Open
The stem bark of Garcinia kola Heckel (Clusiaceae) is frequently used as antitumor in Southern Nigeria. The study aimed to evaluate antioxidant, cytotoxic, and inhibitory activities from the extract and fractions of G. kola and assess thei…
View article: Effects of genetic polymorphism in susceptibility to schistosomiasis infection and adverse treatment outcomes
Effects of genetic polymorphism in susceptibility to schistosomiasis infection and adverse treatment outcomes Open
Schistosomiasis is a serious tropical disease that is undiagnosed (Neglected tropical disease -NTD). The only disease with a more detrimental socio-economic impact than its causative agent is malaria. Over 250 million individuals are prese…
View article: Application of genetic scissoring in the management of genetically related diseases
Application of genetic scissoring in the management of genetically related diseases Open
CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) technology has emerged as a groundbreaking tool for genome editing, revolutionizing the management of genetic diseases. Its precision, efficiency, and adaptability enable t…
View article: Antibacterial and antifungal effects of Hippocratea velutina (Afzel.) leaves and its constituents: Experimental and computational approaches
Antibacterial and antifungal effects of Hippocratea velutina (Afzel.) leaves and its constituents: Experimental and computational approaches Open
Hippocratea velutina (HV) Afzel's application in wound care suggests its antimicrobial property, although no scientific data confirms its efficacy. Therefore, the antibacterial and antifungal properties of HV leaves are assessed in this st…
View article: Antioxidant and ameliorative effects of selected Nigerian plants on hormonal imbalance associated with dysmenorrhea in albino rats
Antioxidant and ameliorative effects of selected Nigerian plants on hormonal imbalance associated with dysmenorrhea in albino rats Open
Introduction Conventional treatments, such as non-steroidal anti-inflammatory drugs (NSAIDs), are widely used for the treatment of dysmenorrhea but are often associated with side effects, necessitating the search for alternative therapies.…
View article: Evaluation of Antioxidant and Membrane Stabilizing Activities of <i>Croton lobatus L.</i> and <i>Croton zambesicus</i> Mull. Arg. Leaves via<i>in vitro</i> and <i>ex vivo</i> studies
Evaluation of Antioxidant and Membrane Stabilizing Activities of <i>Croton lobatus L.</i> and <i>Croton zambesicus</i> Mull. Arg. Leaves via<i>in vitro</i> and <i>ex vivo</i> studies Open
Inflammation is a normal and necessary protective response to harmful stimuli such as infectious agents, antigen-antibody reactions, thermal, chemical, and physical agents, and ischemia. Most drugs used as an anti-inflammatory are analgesi…
View article: andardization, Phytochemistry and Antidiarrhoeal activities of Alstonia boonei De Wild. And Alstonia congensis ENGL. Stem barks
andardization, Phytochemistry and Antidiarrhoeal activities of Alstonia boonei De Wild. And Alstonia congensis ENGL. Stem barks Open
The apparent similarities between Alstonia boonei (AB) and Alstonia congensis (AC), could lead to misidentification and inappropriate medicinal utilization. This study aimed at evaluating pharmacognostic and anti-diarrheal profiles of the …
View article: Bioprospection of indigenous herbal formulations for diabetes care: in vitro, network pharmacology, and molecular dynamics studies
Bioprospection of indigenous herbal formulations for diabetes care: in vitro, network pharmacology, and molecular dynamics studies Open
Background Herbal formulations have garnered significant interest from researchers for their potential antidiabetic effects. However, scientific validation of their efficacy and understanding of their mechanisms of action have limited thei…
View article: Tea Consumption and Diabetes: A Comprehensive Pharmacological Review of Black, White, Green, Oolong, and Pu-erh Teas
Tea Consumption and Diabetes: A Comprehensive Pharmacological Review of Black, White, Green, Oolong, and Pu-erh Teas Open
Diabetes is one of the major non-communicable diseases whose physiological complications are linked with a higher risk of mortality amongst the adult age group of people living globally. This review article documents updated pharmacologica…
View article: Comparative profiling of secondary metabolites and antidiabetic properties of Anogeissus leiocarpus (DC.) Guill. &amp; Perr. (Combretaceae) extracts
Comparative profiling of secondary metabolites and antidiabetic properties of Anogeissus leiocarpus (DC.) Guill. & Perr. (Combretaceae) extracts Open
Background: Diabetes mellitus is a chronic metabolic condition which can result in severe long-term complications, and current treatments often have significant side effects. As a result, there is a growing interest in identifying novel α-…
View article: Pharmacognostic evaluation and antimicrobial activity of Pteridium aquilinum (L.) Kuhn leaves (Onocleaceae) via in vitro and in silico perspectives
Pharmacognostic evaluation and antimicrobial activity of Pteridium aquilinum (L.) Kuhn leaves (Onocleaceae) via in vitro and in silico perspectives Open
Background and objective Traditionally, Pteridium aquilinum L. has been utilized as medicine for ages, however, it is not listed in the Nigerian herbal pharmacopeia, and there is no information regarding its standardization and antimicrobi…
View article: Pharmacognostic standardisation and antioxidant activity of <i>Cassia sieberiana</i> DC. (Fabaceae)
Pharmacognostic standardisation and antioxidant activity of <i>Cassia sieberiana</i> DC. (Fabaceae) Open
Secondary metabolites of medicinal plants can be used as dietary antioxidants, acting as free radical scavengers, radical chain reaction inhibitors, metal chelators, oxidative enzyme inhibitors and antioxidant enzyme cofactors. However, th…
View article: Brine shrimp lethality and antioxidant property of <i>Lagenaria breviflora</i> (Benth.) Roberty fruit crude extract and fractions
Brine shrimp lethality and antioxidant property of <i>Lagenaria breviflora</i> (Benth.) Roberty fruit crude extract and fractions Open
Background: Oxidative injury plays a pivotal impact in the development of human diseases, and it is a major component of the pathophysiology of several inflammation-linked human medical disorders. Objective: The focus of this study was to …
View article: Network Pharmacology, Molecular Dynamics and In Vitro Assessments of Indigenous Herbal Formulations for Alzheimer’s Therapy
Network Pharmacology, Molecular Dynamics and In Vitro Assessments of Indigenous Herbal Formulations for Alzheimer’s Therapy Open
Alzheimer’s disease (AD) is an age-associated neurodegenerative condition marked by amyloid plaques, synaptic dysfunction, and neuronal loss. Besides conventional medical care, herbal therapies, both raw and refined, have attracted researc…
View article: Nutritional, phytochemistry, antioxidant, and antidiabetic potentials of Hippocratea velutina (Afzel.) leaves: In vitro, ex vivo and in silico studies
Nutritional, phytochemistry, antioxidant, and antidiabetic potentials of Hippocratea velutina (Afzel.) leaves: In vitro, ex vivo and in silico studies Open
Background: Hippocratea velutina is a novel folk plant that is used for lowering blood glucose and is hence a potential source of new antidiabetic medication. Therefore, this study was designed to investigate the antidiabetic and antidiabe…
View article: Integrated approach for studying anti-angiotensin converting enzyme activity of triazole derivatives to down-regulate diabetes
Integrated approach for studying anti-angiotensin converting enzyme activity of triazole derivatives to down-regulate diabetes Open
The effects of triazole and its derivatives as anti-angiotensin converting enzyme activity were investigated using combined computational approach. This work is directed at examining the anti-angiotensin converting enzyme activity of the s…
View article: Spilanthes filicaulis (Schumach. & Thonn.) C. D Adam leaf extract prevents assault of streptozotocin on liver cells via inhibition of oxidative stress and activation of the NrF2/Keap1, PPARγ, and PTP1B signaling pathways
Spilanthes filicaulis (Schumach. & Thonn.) C. D Adam leaf extract prevents assault of streptozotocin on liver cells via inhibition of oxidative stress and activation of the NrF2/Keap1, PPARγ, and PTP1B signaling pathways Open
Background Spilanthes filicaulis (Schumach. & Thonn.) C. D Adam is a shrubby plant of the Asteraceae family that has medicinal benefits for the pharmaceutical and cosmetic industries. Purpose The purpose of this study was to assess the eff…
View article: Effects of Dietary Modifications and Physical Activity on Cancer Prevention and Treatment
Effects of Dietary Modifications and Physical Activity on Cancer Prevention and Treatment Open
To prevent and treat cancer, this review aims to assess the goals, mechanisms, and advantages of altered diets and physical exercise. A comprehensive examination of scholarly publications from various databases, including Springer, Scopus,…
View article: Petiveria alliacea L. extract protects against streptozotocin-induced type-2 diabetes by modulating the cAMP/PKA/CREB/cFOS pathway
Petiveria alliacea L. extract protects against streptozotocin-induced type-2 diabetes by modulating the cAMP/PKA/CREB/cFOS pathway Open
Objective: This study was designed to investigate the nephroprotective effect and mechanism of action of a methanolic extract of Petiveria alliacea leaves (MEPAL) in streptozotocin-induced diabetic nephropathy (DN) in rats. Methods: Twenty…
View article: Therapeutic effects of Artocarpus communis J.R.Forst. & G.Forst. seeds on letrozole-induced polycystic ovary syndrome wistar rats
Therapeutic effects of Artocarpus communis J.R.Forst. & G.Forst. seeds on letrozole-induced polycystic ovary syndrome wistar rats Open
Background: Herbal extracts are an effective treatment for polycystic ovarian syndrome (PCOS) and have been shown to improve insulin resistance, hyperandrogenism, sex hormones, ovulation, and PCOS symptoms. Artocarpus communis seed's poten…
View article: Spilanthes filicaulis (Schumach. & Thonn.) C.D. Adams leaves protects against streptozotocin-induced diabetic nephropathy
Spilanthes filicaulis (Schumach. & Thonn.) C.D. Adams leaves protects against streptozotocin-induced diabetic nephropathy Open
Background and objective Diabetic neuropathy (DN) is a complex type of diabetes. The underlying cause of diabetic nephropathy remains unclear and may be due to a variety of pathological conditions resulting in kidney failure. This study ex…
View article: Kigelia africana (Lam.) Benth. fruit inhibits iron-induced lipid peroxidation and ?-amylase enzyme activity
Kigelia africana (Lam.) Benth. fruit inhibits iron-induced lipid peroxidation and ?-amylase enzyme activity Open
Insufficiencies in insulin secretion and/or action cause diabetes mellitus (DM), a complex condition characterized by abnormal blood glucose levels. Diabetes is often treated by modifying either glucose metabolism, lipids metabolism, or bo…
View article: <i>Artocarpus Communis</i> Seed Regulates P53, IRS, HsD17β2, FTO, and CYP11a Genes in Polycystic Ovarian Syndrome Rats
<i>Artocarpus Communis</i> Seed Regulates P53, IRS, HsD17β2, FTO, and CYP11a Genes in Polycystic Ovarian Syndrome Rats Open
Polycystic ovarian syndrome (PCOS) is a prevalent endocrine illness that affects 5-10% of reproductive women globally. It is a multifaceted hormonal disorder characterized by the involvement of numerous molecular mechanisms that contribute…
View article: Sodium 3-phenylpropanoate alleviate oxidative stress and iron-induced testicular toxicity in Wistar rats
Sodium 3-phenylpropanoate alleviate oxidative stress and iron-induced testicular toxicity in Wistar rats Open
Counteraction of adriamycin-induced alterations in cardiac enzymes by Thespesia populnea leaf extractSangeetha Lakshmi A. Rajbanshi, Archana N. Paranjape, Vasu Appanna