Daniel Aston
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Atrial granules as acidic calcium stores in cardiomyocytes Open
Acidic calcium stores significantly influence basal calcium transient amplitude and β-adrenergic responses in cardiomyocytes. Atrial myocytes contain atrial granules (AGs), small acidic organelles that store and secrete atrial natriuretic …
Lysosomal calcium signalling contributes to the acute α-adrenergic response via calcium-stimulated adenylyl cyclase 1 and 8 Open
Summary Inositol trisphosphate (IP 3 ), a calcium (Ca 2+ )-mobilizing second messenger, releases Ca 2+ from the sarcoplasmic reticulum (SR) via IP 3 receptors and modulates adenylyl cyclase (AC) activity in atrial myocytes. Lysosomes parti…
Atrial Granules in Atrial Cardiomyocytes as Acidic Calcium Stores Open
Acidic calcium stores significantly influence basal calcium transient amplitude and β-adrenergic responses in cardiomyocytes. Atrial myocytes express a small acidic organelle called atrial granules (AG), which store and excrete atrial natr…
Lysosomal signalling pathways influence heart rhythm, and regulate atrial function Open
In the heart, endogenous nicotinic acid adenine dinucleotide phosphate (NAADP) triggers lysosomal calcium release to augment sarcoplasmic reticulum (SR) calcium sequestration, producing larger calcium transients. However, the role of lysos…
View article: Lysosomal signalling pathways influence heart rhythm, and regulate atrial function
Lysosomal signalling pathways influence heart rhythm, and regulate atrial function Open
In the heart, endogenous nicotinic acid adenine dinucleotide phosphate (NAADP) triggers lysosomal calcium (Ca 2+ ) release to augment sarcoplasmic reticulum [1] Ca 2+ sequestration, producing larger Ca 2+ transients. However, the role of l…
Lack of efficacy of aprotinin over tranexamic acid in type <span>A</span> aortic dissection repair Open
Background The role of aprotinin in modern cardiac surgery is not well defined. While licensed for use in isolated coronary artery bypass grafting it is more commonly used for cases deemed to be at an increased risk of bleeding. The relati…
Anaesthesia for Minimally Invasive Cardiac Surgery Open
Minimally invasive cardiac surgery (MICS) has been used since the 1990s and encompasses a wide range of techniques that lack full sternotomy, including valve and coronary artery graft surgery as well as transcatheter procedures. Due to the…
Compartmentalisation proteomics revealed endolysosomal protein network changes in a goat model of atrial fibrillation Open
Summary Endolysosomes (EL) are known for their role in regulating both intracellular trafficking and proteostasis. EL help facilitate elimination of damaged membrane and cytosolic proteins, protein aggregates, membranous organelles and als…
View article: Whole-blood Point-of-Care Activated Partial Thromboplastin Time Ratio (APR) is not Accurate Enough to Monitor Heparin Therapy in Patients with Severe Respiratory Failure Secondary to SARS-Cov-2 Infection Supported with Veno-Venous Extracorporeal Membrane Oxygenation (VV-ECMO)
Whole-blood Point-of-Care Activated Partial Thromboplastin Time Ratio (APR) is not Accurate Enough to Monitor Heparin Therapy in Patients with Severe Respiratory Failure Secondary to SARS-Cov-2 Infection Supported with Veno-Venous Extracorporeal Membrane Oxygenation (VV-ECMO) Open
Support with VV-ECMO requires anticoagulation with unfractionated heparin to prevent thrombotic complications. This must be monitored due to bleeding risk. A point-of-care (POC) method of testing aPTT and APR was evaluated for agreement wi…
The influence of nicotinic acid adenine dinucleotide phosphate (NAADP) signalling and the significance of the organization of lysosomes in cardiac myocytes Open
The central role of calcium ions in the generation of contractile force in the heart has been understood for many decades. In many mammals, a large proportion of the calcium responsible for activation of the contractile apparatus is releas…