Daniel Avery
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View article: The COPD risk associated with adulthood weight change and early adulthood BMI: a prospective cohort study
The COPD risk associated with adulthood weight change and early adulthood BMI: a prospective cohort study Open
Background Gaps concerning general adiposity and chronic obstructive pulmonary disease (COPD) are delaying policies for weight interventions in COPD prevention, especially adiposity in early adulthood and weight changes during adulthood. M…
View article: A simulation study of the impact of population-wide lifestyle modifications on life expectancy in the Chinese population
A simulation study of the impact of population-wide lifestyle modifications on life expectancy in the Chinese population Open
It is uncertain how much life expectancy of the Chinese population would improve under current and greater policy targets on lifestyle-based risk factors for chronic diseases and mortality. Here we report a simulation of how improvements i…
View article: Cardiometabolic health and risk of dementia and brain atrophy: a community-based prospective cohort study of 0.5 million adults in China
Cardiometabolic health and risk of dementia and brain atrophy: a community-based prospective cohort study of 0.5 million adults in China Open
Wellcome Trust, MRC, BHF, CR-UK, Kadoorie Charitable Foundation, Chinese MoST and NSFC.
View article: Contrasting associations of blood lipids with risk of myocardial infarction in Chinese and European adults
Contrasting associations of blood lipids with risk of myocardial infarction in Chinese and European adults Open
Aims Little is known about the importance of blood lipids for risk of myocardial infarction (MI) in Chinese vs. European populations. We compared the associations with MI of apolioprotein B (ApoB) vs. low-density lipoprotein cholesterol (L…
View article: Genetic Risk and Prognosis of the First Incident Stroke Survivors
Genetic Risk and Prognosis of the First Incident Stroke Survivors Open
Our study shows that the genetic risk of first stroke also influences the prognosis of stroke survivors, indicating that PRS has the potential to improve stroke prognosis.
View article: Proteome-Wide Genetic Study in East Asians and Europeans Identified Multiple Therapeutic Targets for Ischemic Stroke
Proteome-Wide Genetic Study in East Asians and Europeans Identified Multiple Therapeutic Targets for Ischemic Stroke Open
BACKGROUND: Analyses of genomic and proteomics data in prospective biobank studies in diverse populations may discover novel or repurposing drug targets for stroke. METHODS: We extracted individual cis -protein quantitative trait locus for…
View article: Causal Relevance of Lp(a) for Coronary Heart Disease and Stroke Types in East Asian and European Ancestry Populations: A Mendelian Randomization Study
Causal Relevance of Lp(a) for Coronary Heart Disease and Stroke Types in East Asian and European Ancestry Populations: A Mendelian Randomization Study Open
BACKGROUND: Elevated plasma levels of Lp(a) [lipoprotein(a)] are a causal risk factor for coronary heart disease and stroke in European individuals, but the causal relevance of Lp(a) for different stroke types and in East Asian individuals…
View article: Long-term exposure to fine particulate matter interacting with individual conditions increase breast cancer incidence: a large-scale Chinese cohort
Long-term exposure to fine particulate matter interacting with individual conditions increase breast cancer incidence: a large-scale Chinese cohort Open
Background Breast cancer is the most frequently diagnosed malignancy among women worldwide. This study aimed to investigate the impact of long-term fine particulate matter (PM2.5) exposure on breast cancer incidence in a cohort of 281,152 …
View article: Phenome-wide association of physical activity with morbidity and mortality risk in China: A prospective cohort study
Phenome-wide association of physical activity with morbidity and mortality risk in China: A prospective cohort study Open
Research in high-income countries has established the health benefits of physical activity (PA), but evidence from low- and middle-income countries, including China, where PA patterns vary from those in high-income countries, remains limit…
View article: Phenome-wide associations of polygenic scores for schizophrenia and major depression in 100,000 Chinese adults
Phenome-wide associations of polygenic scores for schizophrenia and major depression in 100,000 Chinese adults Open
China faces significant mental health challenges, with unique associations between mental disorders and other traits observed in its population. Based on summary statistics in East Asian (EAS) and European (EUR) ancestries, we tested assoc…
View article: Cost-Effectiveness of Salt Substitution and Antihypertensive Drug Treatment in Chinese Prehypertensive Adults
Cost-Effectiveness of Salt Substitution and Antihypertensive Drug Treatment in Chinese Prehypertensive Adults Open
BACKGROUND: Recent guidelines recommend antihypertensive drug treatment for prehypertensive individuals with blood pressure between 130/80 and 139/89 mm Hg. This study evaluates the cost-effectiveness of 3 interventions in Chinese prehyper…
View article: An exposome-wide assessment of 6600 SomaScan proteins with non-genetic factors in Chinese adults
An exposome-wide assessment of 6600 SomaScan proteins with non-genetic factors in Chinese adults Open
Background Proteomics offer new insights into human biology and disease aetiology. Previous studies have explored the associations of SomaScan proteins with multiple non-genetic factors, but they typically involved Europeans and a limited …
View article: An exposome-wide investigation of 2923 Olink proteins with non-genetic factors in Chinese adults
An exposome-wide investigation of 2923 Olink proteins with non-genetic factors in Chinese adults Open
Background Previous studies in European populations have identified a large number of genetic variants affecting plasma levels of Olink proteins, but little is known about the non-genetic factors influencing plasma levels of proteins, part…
View article: Proteo-genomic analyses in relatively lean Chinese adults identify proteins and pathways that affect general and central adiposity levels
Proteo-genomic analyses in relatively lean Chinese adults identify proteins and pathways that affect general and central adiposity levels Open
Adiposity is an established risk factor for multiple diseases, but the causal relationships of different adiposity types with circulating protein biomarkers have not been systematically investigated. We examine the causal associations of g…
View article: Conventional and genetic associations of BMI with major vascular and non-vascular disease incidence and mortality in a relatively lean Chinese population: U-shaped relationship revisited
Conventional and genetic associations of BMI with major vascular and non-vascular disease incidence and mortality in a relatively lean Chinese population: U-shaped relationship revisited Open
Background Higher body mass index (BMI) is associated with higher incidence of cardiovascular and some non-cardiovascular diseases (CVDs/non-CVDs). However, uncertainty remains about its associations with mortality, particularly at lower B…
View article: Modelling personal temperature exposure using household and outdoor temperature and questionnaire data: implications for epidemiological studies
Modelling personal temperature exposure using household and outdoor temperature and questionnaire data: implications for epidemiological studies Open
The reliance of outdoor exposure data in epidemiological studies on temperature entails important uncertainties from personal exposure misclassification. We analysed ~88,000 concurrent person-hours of measured personal, household (kitchen …
View article: Modelling personal temperature exposure using household and outdoor temperature and questionnaire data: implications for epidemiological studies
Modelling personal temperature exposure using household and outdoor temperature and questionnaire data: implications for epidemiological studies Open
The reliance of outdoor exposure data in epidemiological studies on temperature entails important uncertainties from personal exposure misclassification. We analysed ~88,000 concurrent person-hours of measured personal, household (kitchen …
View article: Prospective evaluation of the relevance of Epstein–Barr virus antibodies for early detection of nasopharyngeal carcinoma in Chinese adults
Prospective evaluation of the relevance of Epstein–Barr virus antibodies for early detection of nasopharyngeal carcinoma in Chinese adults Open
Background Epstein–Barr virus (EBV) is a major cause of nasopharyngeal carcinoma (NPC) and measurement of different EBV antibodies in blood may improve early detection of NPC. Prospective studies can help assess the roles of different EBV …
View article: Proteomic Analyses in Diverse Populations Improved Risk Prediction and Identified New Drug Targets for Type 2 Diabetes
Proteomic Analyses in Diverse Populations Improved Risk Prediction and Identified New Drug Targets for Type 2 Diabetes Open
OBJECTIVE Integrated analyses of plasma proteomics and genetic data in prospective studies can help assess the causal relevance of proteins, improve risk prediction, and discover novel protein drug targets for type 2 diabetes (T2D). RESEAR…
View article: Proteomic analyses in diverse populations improved risk prediction and identified new drug targets for type 2 diabetes
Proteomic analyses in diverse populations improved risk prediction and identified new drug targets for type 2 diabetes Open
Objective: Integrated analyses of plasma proteomics and genetic data in prospective studies can help assess the causal relevance of proteins, improve risk prediction and discover novel protein drug targets for T2D.Research Design and Metho…
View article: Proteomic analyses in diverse populations improved risk prediction and identified new drug targets for type 2 diabetes
Proteomic analyses in diverse populations improved risk prediction and identified new drug targets for type 2 diabetes Open
Objective: Integrated analyses of plasma proteomics and genetic data in prospective studies can help assess the causal relevance of proteins, improve risk prediction and discover novel protein drug targets for T2D.Research Design and Metho…