Daniel Ayoub
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View article: Advanced Multi-Cell Housing Designs to Prevent Thermal Runaway Propagation in Lithium-Ion Batteries
Advanced Multi-Cell Housing Designs to Prevent Thermal Runaway Propagation in Lithium-Ion Batteries Open
Fire and deflagration that might occur in high-energy content/high-power lithium ion (Li-ion) batteries are due to propagation of thermal runaway (TR) from just a single failing “trigger” cell to the remaining fully-functional cells. Here …
View article: Alternative splicing for tuneable expression of protein subunits at desired ratios
Alternative splicing for tuneable expression of protein subunits at desired ratios Open
The controlled expression of two or more proteins at a defined and stable ratio remains a substantial challenge, particularly in the bi- and multispecific antibody field. Achieving an optimal ratio of protein subunits can facilitate the as…
View article: Structural Analysis of Monoclonal Antibodies with Top-down and Middle-down Electron Transfer Dissociation Mass Spectrometry: The First Decade
Structural Analysis of Monoclonal Antibodies with Top-down and Middle-down Electron Transfer Dissociation Mass Spectrometry: The First Decade Open
Monoclonal antibodies (mAbs) are protein biotherapeutics with a proven efficacy toward fighting life-threatening diseases. Their exceptional healing potential drives the annual increase in the number of novel mAbs and other antibody-like m…
View article: Single-step Protein A and Protein G avidity purification methods to support bispecific antibody discovery and development
Single-step Protein A and Protein G avidity purification methods to support bispecific antibody discovery and development Open
Heavy chain (Hc) heterodimers represent a majority of bispecific antibodies (bsAbs) under clinical development. Although recent technologies achieve high levels of Hc heterodimerization (HD), traces of homodimer contaminants are often pres…
View article: Alterations in rat adipose tissue transcriptome and proteome in response to prolonged fasting
Alterations in rat adipose tissue transcriptome and proteome in response to prolonged fasting Open
Various pathophysiological situations of negative energy balance involve the intense depletion of the body’s energy reserves. White adipose tissue is a central place to store energy and a major endocrine organ. As a model of choice to bett…
View article: Phosphomimetic substitution at Ser-33 of the chloroquine resistance transporter PfCRT reconstitutes drug responses in Plasmodium falciparum
Phosphomimetic substitution at Ser-33 of the chloroquine resistance transporter PfCRT reconstitutes drug responses in Plasmodium falciparum Open
The chloroquine resistance transporter PfCRT of the human malaria parasite Plasmodium falciparum confers resistance to the former first-line antimalarial drug chloroquine, and it modulates the responsiveness to a wide range of quino…
View article: Multiplexed Middle-Down Mass Spectrometry as a Method for Revealing Light and Heavy Chain Connectivity in a Monoclonal Antibody
Multiplexed Middle-Down Mass Spectrometry as a Method for Revealing Light and Heavy Chain Connectivity in a Monoclonal Antibody Open
Pairing light and heavy chains in monoclonal antibodies (mAbs) using top-down (TD) or middle-down (MD) mass spectrometry (MS) may complement the sequence information on single chains provided by high-throughput genomic sequencing and botto…
View article: Top-down analysis of immunoglobulin G isotypes 1 and 2 with electron transfer dissociation on a high-field Orbitrap mass spectrometer
Top-down analysis of immunoglobulin G isotypes 1 and 2 with electron transfer dissociation on a high-field Orbitrap mass spectrometer Open