Daniel B. Forger
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View article: A framework to determine active neurons and networks within the mouse brain reveals how brain activity changes over the course of the day
A framework to determine active neurons and networks within the mouse brain reveals how brain activity changes over the course of the day Open
The mouse brain’s activity changes drastically over a day despite being generated from the same neurons and physical connectivity. To better understand this, we develop an experimental-computational pipeline to determine which neurons and …
View article: Realistic coupling enables flexible macroscopic traveling waves in the mouse cortex
Realistic coupling enables flexible macroscopic traveling waves in the mouse cortex Open
Traveling waves are ubiquitous in neuronal systems across different spatial scales. While microscopic and mesoscopic waves are relatively well studied, the mechanisms underlying the emergence of macroscopic traveling waves remain less unde…
View article: Realistic coupling enables flexible macroscopic traveling waves in the mouse cortex
Realistic coupling enables flexible macroscopic traveling waves in the mouse cortex Open
Traveling waves are ubiquitous in neuronal systems across different spatial scales. While microscopic and mesoscopic waves are relatively well studied, the mechanisms underlying the emergence of macroscopic traveling waves remain less unde…
View article: Realistic coupling enables flexible macroscopic traveling waves in the mouse cortex
Realistic coupling enables flexible macroscopic traveling waves in the mouse cortex Open
Traveling waves are ubiquitous in neuronal systems across different spatial scales. While microscopic and mesoscopic waves are relatively well studied, the mechanisms underlying the emergence of macroscopic traveling waves remain less unde…
View article: Seasonal timing and interindividual differences in shiftwork adaptation
Seasonal timing and interindividual differences in shiftwork adaptation Open
Millions of shift workers in the U.S. face an increased risk of depression, cancer, and metabolic disease, yet individual responses to shift work vary widely. We find that a conserved biological system of morning and evening oscillators, w…
View article: A circadian and app-based personalized lighting intervention for the reduction of cancer-related fatigue
A circadian and app-based personalized lighting intervention for the reduction of cancer-related fatigue Open
Lighting interventions can mitigate fatigue by promoting circadian rhythmicity. We test whether individualized, wearable-based lighting interventions delivered via a mobile app reduce cancer-related fatigue in a randomized controlled trial…
View article: The real-world association between digital markers of circadian disruption and mental health risks
The real-world association between digital markers of circadian disruption and mental health risks Open
While circadian disruption is recognized as a potential driver of depression, its real-world impact is poorly understood. A critical step to addressing this is the noninvasive collection of physiological time-series data outside laboratory…
View article: BDNF-TrkB signaling orchestrates the buildup process of local sleep
BDNF-TrkB signaling orchestrates the buildup process of local sleep Open
Sleep debt accumulates during wakefulness and is accompanied by an increase in slow wave activity (SWA) during sleep, an electroencephalographic (EEG) global marker for sleep need. The use-dependent demands of prior wakefulness increase th…
View article: Unraveling the interplay of circadian rhythm and sleep deprivation on mood: A Real-World Study on first-year physicians
Unraveling the interplay of circadian rhythm and sleep deprivation on mood: A Real-World Study on first-year physicians Open
The interplay between circadian rhythms, time awake, and mood remains poorly understood in the real-world. Individuals in high-stress occupations with irregular schedules or nighttime shifts are particularly vulnerable to depression and ot…
View article: Whole-cortex simulation reveals spatiotemporal patterns emerging from the interplay of network connectivity and intracellular dynamics
Whole-cortex simulation reveals spatiotemporal patterns emerging from the interplay of network connectivity and intracellular dynamics Open
Recent advances in Graphics Processing Unit (GPU) computing have allowed for computational models of whole-brain activity at unprecedented scales. In this work, we use desktop computers to build and simulate a whole-cortex mouse brain mode…
View article: A Framework to Determine Active Connectivity within the Mouse Brain
A Framework to Determine Active Connectivity within the Mouse Brain Open
Tremendous effort has focused on determining the physical connectivity within the mouse brain. However, the strength of connections within the brain constantly changes throughout the 24-hour day. Here, we combine experimental and computati…
View article: The combination of topological data analysis and mathematical modeling improves sleep stage prediction from consumer-grade wearables
The combination of topological data analysis and mathematical modeling improves sleep stage prediction from consumer-grade wearables Open
Wearable devices have become commonplace tools for tracking behavioral and physiological parameters in real-world settings. Nonetheless, the practical utility of these data for clinical and research applications, such as sleep analysis, is…
View article: Efficient assessment of real-world dynamics of circadian rhythms in heart rate and body temperature from wearable data
Efficient assessment of real-world dynamics of circadian rhythms in heart rate and body temperature from wearable data Open
Laboratory studies have made unprecedented progress in understanding circadian physiology. Quantifying circadian rhythms outside of laboratory settings is necessary to translate these findings into real-world clinical practice. Wearables h…
View article: ALSM_version_1_01-25-2023_v2.zip from Efficient assessment of real-world dynamics of circadian rhythms in heart rate and body temperature from wearable data
ALSM_version_1_01-25-2023_v2.zip from Efficient assessment of real-world dynamics of circadian rhythms in heart rate and body temperature from wearable data Open
Computer codes of the ALSM
View article: ALSM_version_1_01-25-2023_v2.zip from Efficient assessment of real-world dynamics of circadian rhythms in heart rate and body temperature from wearable data
ALSM_version_1_01-25-2023_v2.zip from Efficient assessment of real-world dynamics of circadian rhythms in heart rate and body temperature from wearable data Open
Computer codes of the ALSM
View article: A Level Set Kalman Filter Approach to Estimate the Circadian Phase and its Uncertainty from Wearable Data
A Level Set Kalman Filter Approach to Estimate the Circadian Phase and its Uncertainty from Wearable Data Open
The circadian clock is an internal timer that coordinates the daily rhythms of behavior and physiology, including sleep and hormone secretion. Accurately tracking the state of the circadian clock, or circadian phase, holds immense potentia…
View article: Evolution of the repression mechanisms in circadian clocks
Evolution of the repression mechanisms in circadian clocks Open
Background Circadian (daily) timekeeping is essential to the survival of many organisms. An integral part of all circadian timekeeping systems is negative feedback between an activator and repressor. However, the role of this feedback vari…
View article: Risk Factors for COVID-19 in College Students Identified by Physical, Mental, and Social Health Reported During the Fall 2020 Semester: Observational Study Using the Roadmap App and Fitbit Wearable Sensors
Risk Factors for COVID-19 in College Students Identified by Physical, Mental, and Social Health Reported During the Fall 2020 Semester: Observational Study Using the Roadmap App and Fitbit Wearable Sensors Open
Background The COVID-19 pandemic triggered a seismic shift in education to web-based learning. With nearly 20 million students enrolled in colleges across the United States, the long-simmering mental health crisis in college students was l…
View article: The Level Set Kalman Filter for State Estimation of Continuous-Discrete Systems
The Level Set Kalman Filter for State Estimation of Continuous-Discrete Systems Open
We propose a new extension of Kalman filtering for continuous-discrete\nsystems with nonlinear state-space models that we name as the level set Kalman\nfilter (LSKF). The LSKF assumes the probability distribution can be\napproximated as a …
View article: Distinct Circadian Assessments From Wearable Data Reveal Social Distancing Promoted Internal Desynchrony Between Circadian Markers
Distinct Circadian Assessments From Wearable Data Reveal Social Distancing Promoted Internal Desynchrony Between Circadian Markers Open
Mobile measures of human circadian rhythms (CR) are needed in the age of chronotherapy. Two wearable measures of CR have recently been validated: one that uses heart rate to extract circadian rhythms that originate in the sinoatrial node o…
View article: Risk Factors for COVID-19 in College Students Identified by Physical, Mental, and Social Health Reported During the Fall 2020 Semester: Observational Study Using the Roadmap App and Fitbit Wearable Sensors (Preprint)
Risk Factors for COVID-19 in College Students Identified by Physical, Mental, and Social Health Reported During the Fall 2020 Semester: Observational Study Using the Roadmap App and Fitbit Wearable Sensors (Preprint) Open
BACKGROUND The COVID-19 pandemic triggered a seismic shift in education to web-based learning. With nearly 20 million students enrolled in colleges across the United States, the long-simmering mental health crisis in college students was …
View article: Inferring causality in biological oscillators
Inferring causality in biological oscillators Open
Motivation Fundamental to biological study is identifying regulatory interactions. The recent surge in time-series data collection in biology provides a unique opportunity to infer regulations computationally. However, when components osci…
View article: Monitoring Beliefs and Physiological Measures Using Wearable Sensors and Smartphone Technology Among Students at Risk of COVID-19: Protocol for a mHealth Study
Monitoring Beliefs and Physiological Measures Using Wearable Sensors and Smartphone Technology Among Students at Risk of COVID-19: Protocol for a mHealth Study Open
Background The COVID-19 pandemic has significantly impacted lives and greatly affected the mental health and public safety of an already vulnerable population—college students. Social distancing and isolation measures have presented challe…
View article: Predicting circadian phase across populations: a comparison of mathematical models and wearable devices
Predicting circadian phase across populations: a comparison of mathematical models and wearable devices Open
From smart work scheduling to optimal drug timing, there is enormous potential in translating circadian rhythms research results for precision medicine in the real world. However, the pursuit of such effort requires the ability to accurate…