Daniel B. Harmon
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View article: Seed biology and regeneration niche of the threatened cold desert perennial Ivesia webberi A. Gray
Seed biology and regeneration niche of the threatened cold desert perennial Ivesia webberi A. Gray Open
Understanding the regeneration niche is of critical importance for the conservation of rare plants, yet species-specific information is often lacking for key components of the plant life cycle such as seed dormancy and germination. We cond…
View article: Seed biology and regeneration niche of the threatened cold desert perennial Ivesia webberi A. Gray
Seed biology and regeneration niche of the threatened cold desert perennial Ivesia webberi A. Gray Open
Understanding the regeneration niche is of critical importance for the conservation of rare plants, yet species-specific information is often lacking for key components of the plant life cycle such as seed dormancy and germination. We cond…
View article: Climate change contributions to conflict: an analysis of Syria, Yemen and Egypt
Climate change contributions to conflict: an analysis of Syria, Yemen and Egypt Open
Ascriptions of false, causal connections between climate change and conflict sets a dangerous precedent for future refugee migration. Classification of refugees fleeing murderous regimes and/or circumstances, as climate migrants attempting…
View article: Helix-Loop-Helix Factor Id3 (Inhibitor of Differentiation 3)
Helix-Loop-Helix Factor Id3 (Inhibitor of Differentiation 3) Open
Objective: The aim of this study was to unravel mechanisms whereby deficiency of the transcription factor Id3 (inhibitor of differentiation 3) leads to metabolic dysfunction in visceral obesity. We investigated the impact of loss of Id3 on…
View article: Hepatocyte-Specific Ablation or Whole-Body Inhibition of Xanthine Oxidoreductase in Mice Corrects Obesity-Induced Systemic Hyperuricemia Without Improving Metabolic Abnormalities
Hepatocyte-Specific Ablation or Whole-Body Inhibition of Xanthine Oxidoreductase in Mice Corrects Obesity-Induced Systemic Hyperuricemia Without Improving Metabolic Abnormalities Open
Systemic hyperuricemia (HyUA) in obesity/type 2 diabetes facilitated by elevated activity of xanthine oxidoreductase (XOR), which is the sole source of uric acid (UA) in mammals, has been proposed to contribute to the pathogenesis of insul…
View article: The protein acetylase GCN5L1 modulates hepatic fatty acid oxidation activity via acetylation of the mitochondrial β-oxidation enzyme HADHA
The protein acetylase GCN5L1 modulates hepatic fatty acid oxidation activity via acetylation of the mitochondrial β-oxidation enzyme HADHA Open
Sirtuin 3 (SIRT3) deacetylates and activates several mitochondrial fatty acid oxidation enzymes in the liver. Here, we investigated whether the protein acetylase GCN5 general control of amino acid synthesis 5-like 1 (GCN5L1), previously sh…
View article: Adipose tissue-derived free fatty acids initiate myeloid cell accumulation in mouse liver in states of lipid oversupply
Adipose tissue-derived free fatty acids initiate myeloid cell accumulation in mouse liver in states of lipid oversupply Open
Accumulation of myeloid cells in the liver, notably dendritic cells (DCs) and monocytes/macrophages (MCs), is a major component of the metainflammation of obesity. However, the mechanism(s) stimulating hepatic DC/MC infiltration remain ill…
View article: Reduced intestinal lipid absorption and body weight-independent improvements in insulin sensitivity in high-fat diet-fed <i>Park2</i> knockout mice
Reduced intestinal lipid absorption and body weight-independent improvements in insulin sensitivity in high-fat diet-fed <i>Park2</i> knockout mice Open
Mitochondrial dysfunction is associated with many human diseases and results from mismatch of damage and repair over the life of the organelle. PARK2 is a ubiquitin E3 ligase that regulates mitophagy, a repair mechanism that selectively de…
View article: Protective Role for B-1b B Cells and IgM in Obesity-Associated Inflammation, Glucose Intolerance, and Insulin Resistance
Protective Role for B-1b B Cells and IgM in Obesity-Associated Inflammation, Glucose Intolerance, and Insulin Resistance Open
Objective— Little is known about the role(s) B cells play in obesity-induced metabolic dysfunction. This study used a mouse with B-cell–specific deletion of Id3 (Id3 Bcell KO ) to identify B-cell functions involved in the metabolic consequ…